Cytokines, Interferons, and T-Helpers Flashcards Preview

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Flashcards in Cytokines, Interferons, and T-Helpers Deck (25)
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1

What are the 5 Main T-Helpers?

  1. TH1
  2. TH2
  3. TH17
  4. TFH
  5. T-Reg

2

CD40Ligand function?

  1. Binds on CD40 (often on B-cells)
  2. Promotes Class Switch
  3. Can Activate Macrophage (working with IFN-Gamma)

3

What's the main Type 2 interferon?

IFN-Gamma
"Macro Activator"

4

What cytokines does TFH  Produce?

  1. IL-21
  2. AND ICOS

"Six members in 21 pilots"

5

What cytokine(s) make TH2?

IL-4

via GATA3

6

What cytokines does TH17 produce?

  1. IL-17
  2. IL-22
  3. And IL-6

"One after Sweet Sixteen and Big 2-1"
 

7

What cytokines does TH2 Produce?

  1. IL-4
  2. IL-5
  3. IL-13

"TH2 is the Even-Odd Creator"

8

Five Inflammo-kines?

  1. TNF
  2. CXCL8
  3. IL-1 (L +)
  4. IL-6 (L +)
  5. IL-12

9

What cytokines create Treg?

  1. TGF-B
  2. IL-2

via FoxP3

"TGIF, Peace out work week!"

"Gotta Relax for the 2-day weekend"
 

10

What're the two Type 1 interferons? 

IFN-a and IFN-B
Made by most cells
Activate NKs

11

What cytokines create TFH Cells?

  1. IL-6 

via Bcl6

"Six members in 21 pilots"

12

Cytokine for early B-cell development?

IL-7

"Jackpot for lympho growth"
Works on T AND B Development

13

What cytokines create Th1?

  1.  IFN-Gamma
  2.  IL-12

via T-bet

"TH1 is the Auto-Gamma Radiator"
 

14

TH2 Main functions?

  1. Promote B-cell ab production
  2. Pump out IgE
  3. Activate Mast Cells

15

TH1 main functions in immune response?

  1. Activate Macrophages
  2. Stimulate B-cells to make abs
  3. Activate NK cells

16

What does Treg produce?

  1. TGF-B
  2. IL-10
     

"TGIF, Peace out work week!"
"Palms out (10 fingers) means stop!"

17

IL-3 Function?

Hematopoiesis; create lots o' guys.

18

What cytokines does TH1 produce?

-IFN-Gamma

(Also IL-2, IL-3&GM-CSF)
"Th1 is the Auto-Gamma Radiator"

19

IL-12 Function?

Activate NK cells!
(and TH1)

"Dial 12 for the Ninja Killer hot-line!"

20

TFH Main Functions?

  1. B-cell Iso-Switching
  2. Ab production

21

Three functions of IL-2?

  1. Self-T-Cell Proliferation
  2. Augment IG synthesis
  3. Activate NK cells!

22

What cytokine(s) make TH17?

  1. TGF-Beta
  2. IL-6
  3. IL-23

"Thank God it's Friday, June 23rd"
"Sweet 17 Birthday Cake"

23

TH17 main functions?

  1.  (+) Neutrophil
  2. (+) Barrier Integrity

24

Five Innate Cytokines?

  1. IFN-a
  2. IFN-b
  3. TNF-a
  4. IL-12
  5. (Mid-phase) IFN-Gamma

25

Two Adaptive (Late Phase) cytokines?

  1. IL-2
  2. IFN-Gamma