Cytokins Flashcards by Reema Almutairi

Q

What is the cytokines in Regulators of innate immunity (Involved in natural immunity) (Proinflammatory) ?

A

TNF-alpha , IL-1, IL-6 , IL-8 , IL-12 , type 1 interferons

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Q

What is the cytokines in Regulators of adaptive immunity ?

A

CMIR : IL-2, TNF-beta , type 2 IFN
HMIR : IL-4 , IL-5 , IL-13
Inhibition of IR : IL-10 , THF-beta

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Q

What is the Stimulators of hematopoiesis ?

A

1- SCF
2- CSFs
3- IL-3 , IL-7

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Q

What is the is the principle cytokine that
mediates acute inflammation ?

A

Tumor Necrosis Factor-alpha ( TNF-alpha )

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Q

Acts on endothelial cells to stimulate
a st inflammation and coagulation ?

A

Tumor Necrosis Factor-alpha ( TNF-alpha )

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Q

Stimulates the liver to produce acute
phase proteins is ?

A

Tumor Necrosis Factor-alpha ( TNF-alpha )

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Q

Interacts with the hypothalamus to induce
fever (endogenous pyrogen) is ?

A

Tumor Necrosis Factor-alpha ( TNF-alpha )

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Q

Cachectic factor (muscle proteolysis and
fat catabolism) is the ?

A

Tumor Necrosis Factor-alpha ( TNF-alpha )

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Q

Interleukin-1 (IL-1) is Produced by ?

A

MO,macrophages, dendritic cells and a variety of
other cells

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Q

production by the macrophage
is stimulated by TNF and by the
presence of microbial products as
LPS (exogenous pyrogen) is ?

A

Interleukin-1 (IL-1)

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Q

It acts on the hypothalamus increasing
the body temperature causing fever
(endogenous pyrogen) is ?

A

IL-1

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Q

It acts on liver to induce production of
acute phase proteins is ?

A

IL-1

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Q

IL-1 and TNF-alpha is ?

A

Redundancy يعملون نفس الوظيفة

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Q

Initiation & Coordination of the IR ?

A

IL-1

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Q

IL-6 is stimulates the ?

A

stimulates the liver to produce acute
phase proteins.

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Q

Example of Alpha - chemokines ?

A

IL- 8 and eotaxins

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Q

Example of Beta- chemokines ?

A

RANTES and MCAF

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Q

What the cytokines that Principal mediator of early innate
immune responses to intracellular
microbes ?

A

Interleukin-12 (IL-12)

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Q

What is the key inducer of CMI ?

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A

Interleukin-12 (IL-12)

Q

IFN-alpha (

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A

Mononuclear phagocytes

Q

IFN-beta. ( fibroblast IFN ) produced by ?

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A

many cells, such as fibroblasts.

Q

What is the function of Cytokines that Regulate Adaptive Immune Responses ?

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A

proliferation and differentiation of B lymphocytes and T
lymphocytes

Q

What is the growth factor for NK cells ?

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A

Interleukin-2 (IL-2)

Q

TH0 to TH1 by ?

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A

IL-12

TH0 to TH2 by ?

IL-4

TH1 to TH2 by ?

IL-2

IL-4 is produced mainly by?

TH2 cells and mast cells.

What is a major stimulus for production of IgE !

IL-4

What is the cytokines that isotype switching to IgE ?

IL-4

IL-13 is Produced primarily by ?

TH2 cells

Increases mucus production by lung epithelial cells and may play a role in asthma. increase secretion in the airways is ?

IL-13

What is the cytokines that growth and activating factor for eosinophils as a defense against helminths ?

IL-5

TH0 to TH17 by ?

IL-1 , IL-6 , IL -23

Intracellular pathogen ?

TH1

Extra cellular pathogen ?

TH2

Allergy and Asthma ?

TH2

Parasitic infection?

TH2

Promote innate mucosal immunity?

TH17

Fungal infection?

TH17

Extra cellular bacteria , Autoimmunity ?

TH 17

IL-17 deficiency leads to ?

mucocutaneous candidiasis.

Stem cell factor It is made mainly by ?

bone marrow stromal cells

acts on immature lymphoid progenitors is ?

IL-7

IL-3 supports the growth of ?

multi-lineage bone marrow stem cells

What is the Inhibitory Cytokines ?

IL-10 , Transforming growth factor-beta ( TGF-beta. )