Dapagliflozin

Question 1

Class of Drug

Answer 1

Sodium-glucose co-transporter inhibitor (SGLT-2 inhibitor)

Question 2

MOA

Answer 2

Inhibits SGLT-2 transporter on luminal side of proximal convoluted tubule. Leads to less glucose absorption on basolateral side to the blood. More glucose is excreted in the urine

Question 3

Drug-drug interactions?

Answer 3

Anti-hypertensives (the glucose leaving in the urine is also drawing out water, so that is decreasing circulating blood volume, and therefore decreasing BP)

Other hypoglycaemic agents

Question 4

Adverse side effects

Answer 4

-glucosuria
-UTI
-genital infection
-DKA (rare)
-polydipsia (thirst)
-polyuria
-low BP

Question 5

Common Indications?

Answer 5

T2DM
symptomatic chronic HFrEF
CKD