Day 1

Question 1

What is the result of the activation of the hemostatic mechanism?

Answer 1

Formation of a thrombus or platelet plug

Question 2

Platelet adhesion to exposed collagen within the endothelium of the vessel was, describes which type of hemostasis?

Answer 2

Primary hemostasis(platelet)

Question 3

Enzymatic activation of coagulation proteins to produce fibrin from fibrinogen, describes which type of hemostasis?

Answer 3

Secondary hemostasis (coag)

Question 4

What is vasoconstriction and why does it occur?

Answer 4

Damaged blood vessels contracts to decrease blood flow

Question 5

What two things must be true about platelets in order for a platelet plug to form?

Answer 5

Must be adequate in numbers

Must be functioning normally

Question 6

What are the 5 steps of the hemostatic mechanism?

Answer 6

• Vasoconstriction
• diversion of blood flow
• Initiation of contact activation of platelets
• Activation: intrinsic & extrinsic =fibrin clot
• Slow lysis of the clot occurs over time and the injury heals

Question 7

What factor is the precursor of fibrin?

Answer 7

Factor I

Question 8

What is the name of Factor VIII?

Answer 8

Antihemophilic Factor

Question 9

What factor can be found in all body tissues and converts prothrombin to thrombin?

Answer 9

Factor III (Tissue Thromboplastin)

Question 10

What factor is known as Proaccelerin or Labile Factor?

Answer 10

Factor V

Question 11

What factor is the most abundant of the vitamin K-dependent clotting proteins?

Answer 11

Factor II (Prothrombin)

Question 12

What factor is not destroyed or consumed in the clotting process and is essential only for the extrinsic pathway?

Answer 12

Factor VII (Proconvertin or Stable Factor)

Question 13

Which factor helps to activate thromboplastin and convert prothrombin to thrombin? It also serves as a bridge between platelets and clotting factors?

Answer 13

Factor IV

Question 14

What factor’s absence causes hemophilia B?

Answer 14

Factor IX(Plasma Thrombin Component)

Question 15

What factor is also known as Hageman Factor?

Answer 15

Factor XII

Question 16

What is the name for factor X?

Answer 16

Stuart-Prower Factor

Question 17

What factor is essential for the intrinsic pathway, does not depend on vitamin K, and is synthesized in the liver?

Answer 17

Factor XI

Question 18

What factor stabilizes the fibrin clot and is important in tissue growth and repair?

Answer 18

Factor XIII (Fibrin Stabilizing Factor)

Question 19

What factor activates plasminogen?

Answer 19

Fletcher Factor (Prekallikrein)

Question 20

What factor is also known as High Molecular Weight Kininogen?

Answer 20

Fitzgerald Factor

Question 21

What are the three components of the hemostatic mechanism?

Answer 21

• Extravascular effects
• Vascular effects
• Intravascular effects

Question 22

What is the function(s) of platelets?

Answer 22

Release substance for vasoconstriction, platelet aggregation, coagulation and vascular repair

Question 23

Coagulation factors are _______ in nature with the exception of calcium .

Answer 23

Protein

Question 24

What are the three groups of coagulation factors and what are included in each?

Answer 24

Fibrinogen Group
Prothrombin Group
Contact Group

Question 25

What coagulation factor group doesn’t require vitamin K for synthesis?

Answer 25

Fibrinogen Group

Question 26

What coagulation factor group contains factors that are stable?

Answer 26

Prothrombin Group

Question 27

What is one of the body’s most important natural defense mechanisms?

Answer 27

Hemostasis

Question 28

What does hemostatic mechanism assure?

Answer 28

That clots in the body are formed only when they should be

Question 29

What is the name for factor I?

Answer 29

Fibrinogen

Question 30

What is the name for factor II ?

Answer 30

Prothrombin

Question 31

What is the name for factor III?

Answer 31

Tissue Thromboplastin

Question 32

What is the name for factor IV?

Answer 32

Ionized Calcium

Question 33

What is the name for factor V?

Answer 33

Proaccelerin or Labile Factor

Question 34

What is the name for factor VII

Answer 34

Proconvertin or Stable factor

Question 35

What is the name for factor VIII?

Answer 35

Antihemophilic Factor

Question 36

What is the name for factor IX?

Answer 36

Plasma Thromboplastin Component

Question 37

What is the name for factor X?

Answer 37

Stuart-Prower Factor

Question 38

What is the name for factor XI?

Answer 38

Plasma Thromboplastin Antecedent

Question 39

What is the name for factor XII?

Answer 39

Hageman Factor

Question 40

What is the name for factor XIII?

Answer 40

Fibrin Stabilizing Factor

Question 41

Which factor is essential only for extrinsic coagulation pathway?

Answer 41

Factor VII

Question 42

Which factor serves as a bridge between platelets and clotting factors?

Answer 42

Factor IV

Question 43

True or False: | Factor VI exists

Answer 43

False, there is no Factor VI

Question 44

Which factor has the longest half-life of the vitamin K dependent clotting proteins?

Answer 44

Factor II

Question 45

Which factor converts prothrombin to thrombin?

Answer 45

Factor III

Question 46

Which factor is the most abundant of the vitamin K dependent clotting proteins?

Answer 46

Factor II

Question 47

Which factor is synthesized by the liver and does not require vitamin K for production?

Answer 47

Factor I

Question 48

Which factor is a precursor of fibrin?

Answer 48

Factor I

Question 49

Which factor helps to activate Thromboplastin and convert prothrombin to thrombin?

Answer 49

Factor IV

Question 50

Which factors activity deteriorates within a few hours?

Answer 50

Factor V

Question 51

Which factor is not destroyed nor consumed in the clotting process?

Answer 51

Factor VII

Question 52

Which factors deficiency causes hemophilia?

Answer 52

Factor VIII

Question 53

Which factor cause hemophilia A and Von Willebrand’s disease?

Answer 53

Factor VIII

Question 54

What is a sex linked, recessive coagulation disorder?

Answer 54

Hemophilia A

Question 55

Autosomal inheritance describes what disease?

Answer 55

Von Willebrand’s disease

Question 56

What disorder cause bleeding into the joints and intramuscular hemorrhage?

Answer 56

Hemophilia A

Question 57

Which disorder has a normal bleeding time?

Answer 57

Hemophilia A

Question 58

Platelets cannot adhere properly to subendothelial surface, causing severe hemorrhaging, describes what disease?

Answer 58

Von Willebrand’s disease

Question 59

What disease has a consistent abnormal bleeding time?

Answer 59

Von Willebrand’s disease

Question 60

The absence of which factor causes Hemophilia B?

Answer 60

Factor IX

Question 61

Which factor results in prolonged PT AND APTT but normal bleeding time?

Answer 61

Factor IX

Question 62

Which factor is synthesized in the liver and vitamin K dependent?

Answer 62

Factor X

Question 63

What are the Three Categories of Factors?

Answer 63

Fibrinogen Group Prothrombin Group Contact Group

Question 64

Which factors are in the contact group?

Answer 64

Factors XI, XII, Fletcher/Prekallikrein & HMWK

Question 65

What factors are included in the Prothrombin Group?

Answer 65

II, VII, IX, X

Question 66

What factors are included in Fibrinogen Group?

Answer 66

I, V, VIII, XIII

Question 67

Which group requires Vitamin K for synthesis?

Answer 67

Prothrombin Group

Question 68

Which Group doesn’t depend on Vitamin K for synthesis?

Answer 68

Contact Group

Question 69

Which group does not require Vitamin K for synthesis?

Answer 69

Fibrinogen Group

Question 70

What circumstances are Fibrinogen group factors increased?

Answer 70

Pregnancy, inflammation, and with oral conception use(birth control)

Question 71

When would Prothrombin group factors be decreased?

Answer 71

In acquired Vitamin K deficiencies

Question 72

Prothrombin Group factors are __________.

Answer 72

Stable

Question 73

Factors V and VIII are _______.

Answer 73

Labile

Question 74

_______________ and _______ aid in the activation of the clot lysing enzyme plasminogen.

Answer 74

Prekallikrein and HMWK

Question 75

List Vitamin K dependent factors

Answer 75

II VII IX X