Deck 1

Question 1

Clinical clues for ASD

Answer 1

• Right ventricular heave
• Wide, fixed splitting of the second heart sound
• Mid systolic pulmonary flow or ejection murmur
• Right axis deviation and incomplete RBBB

Question 2

Important ASD complications

Answer 2

• Atrial arrhythmias (Afib and flutter)
• Stroke due to paradoxical embolization
• Migraine headache
• Pulmonary hypertension and Eisenmenger syndrome

Question 3

Clinical features of CVID (common variable immune deficiency)

Answer 3

• Recurrent infections (rhinosinusitis, pneumonia, conjunctivitis)
• Chronic lung disease (bronchiectasis)
• Autoimmune disorders (vitiligo, RA, thyroid)
• GI disorders (IBS, malabsorption)
• Granulomatous dz
• Increase risk of malignancy (lymphoma, gastric CA)

Question 4

Diagnosis of CVID (common variable immune deficiency)

Answer 4

Extremely persistent low IgG levels
Low IgA and/or IgM levels
No response to vaccinations
Exclusion of other immunodeficiency disorders

Question 5

Treatment of CVID (common variable immune deficiency)

Answer 5

Immunoglobulin replacement therapy
Age-appropriate cancer screening
Monitoring for lymphoma

Question 6

Adult CF

Answer 6

Mild respiratory infections, GI disease (recurrent pancreatitis, biliary cirrhosis, portal HTN), abnormal reproductive function

Question 7

Myeloperoxidase deficiency

Answer 7

Asymptomatic or recurrent Candida infections

Question 8

Primary ciliary dyskinesia

Answer 8

Nasal polyposis, otitis, recurrent respiratory infections, situs inversus (50% of pts), infertility

Question 9

Onychomycosis diagnosis

Answer 9

KOH (potassium hydroxide) preparation from nail scrapings