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Deferrals Flashcards

1
Q

Double red cell apheresis

A

16 weeks deferral post donation

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2
Q

Been in juvenile detention, lockup fail or prison for more than 72 consecutive hours

A

12 months deferral

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3
Q

Did you spend time that adds up to 5 years or more in the united kingdom between 1980-1996

A

permanent deferral

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4
Q

Did you spend time that adds up to 5 years or more in certain european countries or had a blood transfusion there between 1980 and present?

A

permanent deferral

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5
Q

Maximum hgb/hct for red cell unit apheresis donation

A

20g/dl or 60% hct

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6
Q

Maximum hgb/hct for plateletpheresis, plasmapheresis, or leukapheresis

A

18 g/dl or 54% hct

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7
Q

Donating rbc apheresis, hgb/hct level

A

minimum 13.3 g/dl or 40% hct

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8
Q

IV drug user for nonprescribed drugs

A

permanent deferral

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9
Q

donor is prostitute

A

permanent deferral

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10
Q

donor hired a prostitute

A

1 year deferral

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11
Q

MSM

A

1 year deferral

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12
Q

HIV window period for NAT

A

9 days

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13
Q

HCV window period for NAT

A

8 days

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14
Q

HCV window period EIA

A

70 day window

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15
Q

MP-NAT and WNV/ZIKA

A

low viral titers can be missed with mini-pooled testing, each sample must be tested individually so positive test is not missed. ID-NAT

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16
Q

ID-NAT

A

individual NAT

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17
Q

postive with EIA or Chlia-first time

A

recorded as initially reactive- must be repeated, upon repeat positive-confirmed through other testing platform/different manufacturer if available

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18
Q

anti-HCV test positive first time

A

confirmatory testing is HCV NAT or 2nd manufacturers EIA/ChLIA assay

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19
Q

HIV-1 antibody positive first time

A

confirmatory testing is Western blot or immunofluorescence assay

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20
Q

HIV-2 positive

A

confirmatory testing additional anti-HIV-2 supplemental assay required

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21
Q

T. cruzii positve antibody test

A

confirmatory test done by recombinant antigen based immunoblot assay.

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22
Q

Anti-Hbc positive test first time

A

deferall not necessary 2 independent tests are positve- then permanent deferral, some donor centers make deferral after 1st positive, this is not required.

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23
Q

When EIA test is positive

A

must repeat in duplicate if both duplicates are negative- considered negative, if either of these is positive this is considered a positive for this unit, unit discarded, donor indefintely deferred.

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24
Q

How many infectious disease are mandatory for testing? what are they?

A
  1. HIV, HCV, HBV, HTLV, WNV, ZIKA, T. cruzii, syphilis
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25
How many of the 8 mandatory tests have an EIA/Chlia test? Which ones?
6. anti-HIV 1/2, HBsag, anti-HBc, anti-HCV, HTLV 1/12, T. cruzii antibody
26
confirmatory testing of T. cruzii, positive
antibody positive needs to be confirmed by recombinant antigen-based immunoblot assay.
27
most common viral transmission agent via transfusion
HBV
28
Permanent deferral for risk associated with HIV infection (3)
1.Prostitution of self 2. injection of drugs into system-non-prescribed 3. previous positive results for HIV test
29
testing for HBsag, anti-HCV positive, followed by positive confirmatory testing
permanent deferral of donor
30
anti-HBc positive 2x
permanent deferral
31
lived with someone with hepatitis
deferral for 12 months-from time living with individual ceases.
32
Deferral for positive WNV
deferred 120 days
33
Deferral positive for Zika
deferred 120 days
34
3 year deferral for malarial risks: (2)
1. lived for combined more than 5 years in malarial endemic area 2. was symptomatic for malaria-since last symtoms
35
1 year deferral for malarial risks
If prospective donor does not live in endemic country, but visited an endemic country, never developed malarial symptoms, one year from date returned to non endemic area.- must be in endemic area for more than 24 hours (not drive through area)
36
Ever positve for Chaga's or Babesia
permanent deferral
37
Permanent deferral risk factors CJD (8)
1. dura mater graft 2. realative with CJD 3. human pituitary growth hormone 4. 3 months in UK 1980-1996, 5.in military in europe 1980-1996 6. received a transfusion in UK or France 1980-present 7. received bovine insulin injection sourced from UK or other countries with BSE 8. Spent time that adds up to 5 years or more in Europe from 1980-present
38
Measles deferral
2 week
39
Mumps deferral
2 week
40
oral polio
2 week
41
oral typhoid
2 week
42
yellow fever
2 week
43
rubella
4 week
44
VZV
4 week
45
Rubeolla
2 week
46
History of hematological malignancy
donor permanently deferred
47
History of solid organ tumor
deferred until clinically cured (1-5 years depending)
48
isotretinoin
one month deferral
49
finasteride
one month deferral
50
dutasteride
six month deferral
51
acitretin
three year deferral
52
etretinate
permanent deferral
53
bovine or human growth hormone from pituitary gland
permanently deferred
54
clopideogrel
2 weeks deferral -if for platelets
55
ticlopidine
2 weeks deferral- if for platelets
56
aspirin
48 hours deferral
57
warfarin, heparin, anticoagulants
termporarily deferred, causes poor efficacy of plasma component and increased risk to donor
58
Female donor post delivery
6 week deferral after delivery
59
apheresis platelet- single unit
2 day deferral post donation, no more than 2/7days or 24/12 months
60
apheresis platelet- double or triple unit
7 days in between donations
61
occasional plasmapheresis donors interval, maximum donations
can donate once in 4 weeks, max 13 donations per year, maximum 12L in 12 months.
62
frequent plasmapheresis donors
at least 48 hours between two procedures, no more than 2/7 days (same as apheresis platelets).
63
Maximum RBC loss in plasmapheresis
cannot lose more than 25 mL/week
64
Testing quantities for frequent plasma donation
must be tested for total protein and serum protein electrophoresis OR quantitative immunglobulins, results need to be normal.
65
interval between WB donations
8 weeks
66
neutrophil stimulation of donors for granulocytes, drugs
G-CSF, and dexamethasone (steroids) are at maximum 12 hours after given drugs
67
requirements for granulocytes donors-
must aborh match recipient, donor cannot be pregnant as G-CSF not approved for pregnancy, cannot have hemoglobinopathies, no history of allergy to steroids or starch (HES), shoul dnot have hypertension, diabetes, GI ulcers, tuberculosis or fungal infections- poor reaction with steroid treatment.
68
deferral after granulocytes donation
8 weeks between WB donation- 2 days between additional granulocytes donation no more than 2/7 days

SBB (31 decks)

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