DEFINITIONS

Question 1

What is the plasma half life ?

Answer 1

The time it takes for the drugs plasma concentration to decrease by 50%

Question 2

How long does it take for a drug to reach its steady state concentration ?

Answer 2

5 half lives

Question 3

Metabolism of a drug most commonly results in the drug becoming what ?

Answer 3

More water soluble

Question 4

A decrease in renal function which may be seen in the older person could do what to the drugs half life ?

Answer 4

Increase it

Question 5

How will liver dysfunction effect pharmacology administration ?

Answer 5

Decrease clearance of drug decreased hepatic metabolism

Decreased plasma protein binding, effecting distribution and elimination .

Question 6

Define steady state concentration

Answer 6

Occurs when the amount of drug being absorbed is the same as the amount of drug thats being cleared.

It’s the time in which the the concentration of the drug stays consistent.