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Definitions Flashcards

1
Q

acantholysis

A

Loss of cell-cell adhesion

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2
Q

Acanthosis

A

Increase in thickness of epidermis

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3
Q

anaplasia

A

Atypical nuclei (size, shape, staining) and pleomorphism (variation in nuclear characteristics)

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4
Q

Apoptosis

A

“dead red” keratinocytes with pyknotic nuclei

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5
Q

arborizing

A

branching (rete; vasculature)

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6
Q

asteroid body

A
  • Collections of pink material in sporotrichosis
  • Star-shaped intracytoplasmic inclusions in giant cells of granulomatous processes (sarcoid)
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7
Q

Atrophy

A

decrease in epidermal thickness

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8
Q

Ballooning degeneration

A

Destruction of epidermis by dissolution of cell attachments and intracellular edema (HSV)

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9
Q

Caterpillar body

A

Degenerated type IV collagen –> Pale pink linear BM material within epidermis (ex: PCT)

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10
Q

Civatte/colloid bodies

A

Pink, globular remnants of keratinocytes

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11
Q

Collagen entrapment

A

Collagen fibers surrounded by histiocytes/spindle cells (ex: dermatofibroma)

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12
Q

Cornoid lamellae

A

Parakeratosis in a column above hypogranulosis and pink dyskeratotic keratinocytes at base (ex: porokeratosis)

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13
Q

Corps ronds

A

rounded nucleus with halo of pink dyskeratotic cytoplasm (ex: Darier)

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14
Q

Grains

A

dark blue flattened nucleus surrounded by minimal cytoplasm (ex: Darier’s)

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15
Q

Dyskeratosis

A

abnormal, individual-cell keratinization

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16
Q

Cowdry / Lipschutz body

A

Pink intranuclear inclusions - Cowdry A: herpesvirus - Cowdry B: adenovirus, poliovirus

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17
Q

Crust

A

Serum/fluid with inflammatory cells/debris in stratum corneum

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18
Q

Donovan body

A

Intracytoplasmic collections of bacteria seen in granuloma inguinale

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19
Q

Dutcher body

A

Intracytoplasmic pink masses of immunoglobulin that invaginate into the nucleus of plasma cells, making them appear intranuclear

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20
Q

Effacement

A

Loss of normal rete pattern

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21
Q

Eosinophilic spongiosis

A

Spongiosis with eosinophils in the epidermis

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22
Q

psoriasiform

A

regular acanthosis

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23
Q

pseudoepitheliomatous hyperplasia

A

irregular acanthosis

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24
Q

Epidermolytic hyperkeratosis

A

disruption of cell membranes –> coarse, irregular hypergranulosis

  • Keratin 1 and 10 mutations
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25
epidermotropism
lymphs in epidermis w/NO spongiosis (MF only)
26
erosion
partial thickness loss of epidermis
27
exocytosis
lymphs in epidermis + spongiosis (spong derm)
28
festooning
undulating patterin of papillary dermis (i.e. PCT)
29
flame figure
collagen encrusted with major basic protein from eos (i.e. Wells synd)
30
foam cell
histiocyte filled with lipids
31
follicular mucinosis
pools of mucin alter hair sheath anatomy
32
granulomatous
composed of granulomas (discrete collections of histiocytes)
33
grenz zone
uninvolved area of dermis, either beneath epidermis or adjacent to hair follicle
34
Guarnieri body
eosinophilic inclusions (smallpox)
35
Henderson-Paterson body
oval, pink, intracytoplasmic inclusions (molluscum)
36
hyper-/hypogranulosis
increased or decreased granular layer
37
hyper-/hypopigmentation
increased or decreased melanin pigment
38
interface
related to D-E junction
39
Kamino body
dull pink BM material within epidermis (spitz nevus)
40
karyorrhexis
fragmentation of neutrophils (leukocytoclasia(
41
koilocytes
keratinocytes with clear cytoplasm and shrunken (pyknotic) nuclei
42
Leishman-Donovan body
intracytoplasmic collections of amastigotes (leishmaniasis)
43
lentiginous epidermal hyperplasia
elongated, bulbous rete ridges
44
lentiginous melanocytic growth pattern
proliferation predominantly along D-E junction
45
leukocytoclasia
fragmentation of neutrophils (karyorrhexis)
46
lichenoid dermatitis
interface dermatitis with destruction of basal layer + Civatte bodies
47
lichenoid infiltrate
bandlike infiltrate, usually of lymphs, at D-E junction
48
Medlar body
round brown structure resembling overlapping copper pennies (chromomycosis)
49
metachromasia
property of staining a different color than stain itself (i.e. mast cell granules stain purple with methylene blue)
50
Michaelis-Gutman body
intra- and extracellular calcified, concentric circular structures (malakoplakia)
51
Munro microabscess
collection of neuts in stratum corneum (psoriasis)
52
necrobiosis
pale-staining, smudged, necrotic collagen
53
Negri body
intraneuronal inclusions (rabies)
54
Orthokeratosis
stratum corneum without retained nuclei
55
pagetoid cells
large cells w/abundant cytoplasm within epidermis
56
pagetoid scatter
atypical cells scattered throughout epidermis
57
palisading
picket fence-like arrangement of cells at periphery
58
papillary mesenchymal body
structure resembling whorl of plump mesenchymal cells normally found in hair papilla (trichoblastoma, trichoep)
59
papillomatosis
exophytic, finger-like projections
60
parakeratosis
stratum corneum with retained nuclei
61
pigment incontinence
melanin within dermal macrophages and free within the dermis
62
pleomorphism
variation in nuclear size/shape
63
psammoma body
extracellular, laminated, calcified structures (meningioma, papillary thyroid carcinoma, ovarian carcinoma)
64
pseudoepitheliomatous hyperplasia
prominent acanthosis of adnexal epithelium and epidermis; often assoc w/trapping of elastic fibers - mimics SCC
65
pseudohorn cyst
keratin-filled cystic structure caused by cutting through invaginations of stratum corneum (connects to surface)
66
reticular degeneration
epidermal destruction with residual net-like cell membranes
67
reticulated
net-like network of interconnecting strands
68
Russell body
pink, intracytoplasmic collections of immunoglobulin in plasma cells (rhinoscleroma)
69
Schaumann body
laminated, calcified structure (sarcoidosis)
70
shadow cells
cells w/barely visible outlines of nuclei (pilomatricoma)
71
spongiform pustule of Kogoj
neuts in stratum spinosum, assoc w/spongiosis at periphery (psoriasis)
72
spongiosis
intercellular edema in epidermis with stretching of cell-cell junctions
73
squamatization
loss of cuboidal/columnar basal cells; deepest layer replaced bu polyhedral, pink, squamous cells
74
squamous eddies
circular whorls of squamous cells
75
storifom
"cartwheel" or loosely-whorled pattern
76
vacuolar change
formation of clear spaces w/i basal layer
77
verocay body
structure composed of two nuclear palisades enclosing pink cytoplasmic processes (schwannoma)
78
villus
papillary dermis covered by layer of epidermal cells, projecting into a cavity

Dermpath (4 decks)

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