Degenerative Joint Disease - Drugs Flashcards
1
Q
Corticosteroids
A
Phospholipase inhibitor
- stabilizes cell membranes
- decreases: prostaglandin synthesis, adhesion molecule synthesis, proteoglycan and collagen formation
2
Q
NSAIDs
A
Cyclooxygenase inhibitor
- decreases prostaglandin synthesis
- mixed effects on proteoglycan synthesis
3
Q
Hyaluronic acid
A
Steric hindrance, matrix interactions
- re-establishes synovial fluid
- blocks metalloproteinase activation
- stops proteoglycan release from cartilage
- may increase proteoglycan synthesis
4
Q
Polysulfated glycosaminoglycan
A
Chondroprotective replacement GAG
- inhibit lysosomal and metalloproteinase synthesis
- increases hyaluronic acid synthesis
- possible increase chondrocyte metabolism
5
Q
DMSO
A
Anti-inflammatory
- cell membrane stabilization
- free radical scavenger
6
Q
Glucosamine
A
Matrix precursor, enzyme inhibition
- increase proteoglycan and collagen formation
- anti-inflammatory via inhibition of lysosomal activity and free radical production
7
Q
Chondroitin sulfate
A
Matrix precursor, enzyme inhibition
- inhibits enzyme that degrade cartilage matrix and hyaluronic acid
- increase proteoglycan synthesis
8
Q
I-RAP
A
Inhibits binding of interleukin-1
- inhibits initial steps of inflammatory cascade, resulting in decreased production of destructive metalloproteinase enzymes by chondrocytes
