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Flashcards in dek pesawat dan kabin Deck (146)
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1

Which of the following is the correct representation of the subunits of the acetylcholine (ACh) receptor at neuromuscular junction?
A. Alpha Beta Gamma Delta
B. Alpha2 Beta Gamma Delta
C. Alpha Beta2 Gamma Delta
D. Alpha Beta Gamma2 Delta
E. Alpha Beta Gamma Delta2

B

2

Which of the following is true of the alphasubunit of the nicotinic acetylcholine receptor?
A. it contains four hydrophobic transmembrane portions
B. The binding site is not located on the alpha subunit
C. The cytoplasmic loop is themost highly conserved portion of the subunit
D. The N-Terminal is extracellular and the C-terminal is intracellular
E. The transmembrane portion is the least conserved segment

A

3

The number of binding sites on the nicotinic acethylcholine receptor is
A.1
B.2
C.3
D.4
E.5

B

4

Binds GABA
A. Alpha subunit of GABA a receptor
B. Beta subunit of GABA a receptor
C. Both
D. Neither

C

5

Binds Benzodiazepines
A. Alpha subunit of GABA a receptor
B. Beta subunit of GABA a receptor
C. Both
D. Neither

A

6

Most closely linked with synaptic plasticity and cell death
A. GABA receptor
B. Glutamate receptor
C. Glycine receptor
D. Nicotinic ACh receptor
E. Serotonin (5-HT) receptor

B

7

GABA and this receptor are permeable to chlorid ions
A. GABA receptor
B. Glutamate receptor
C. Glycine receptor
D. Nicotinic ACh receptor
E. Serotonin (5-HT) receptor

C

8

Binds strychine
A. GABA receptor
B. Glutamate receptor
C. Glycine receptor
D. Nicotinic ACh receptor
E. Serotonin (5-HT) receptor

C

9

Binds benzodiazepine
A. GABA receptor
B. Glutamate receptor
C. Glycine receptor
D. Nicotinic ACh receptor
E. Serotonin (5-HT) receptor

A

10

One type of this receptor is both ligand and voltage regulated
A. GABA receptor
B. Glutamate receptor
C. Glycine receptor
D. Nicotinic ACh receptor
E. Serotonin (5-HT) receptor

B

11

One type of this receptor is blocked by magnesium ions
A. GABA receptor
B. Glutamate receptor
C. Glycine receptor
D. Nicotinic ACh receptor
E. Serotonin (5-HT) receptor

B

12

Significantly permeable to calcium ions
A. Kainate receptor only
B. NMDA receptor only
C. Quisqualate / AMPA receptor only
D. A and B
E. A, B, C

B

13

Permeable to monovalent cations
A. Kainate receptor only
B. NMDA receptor only
C. Quisqualate / AMPA receptor only
D. A and B
E. A, B, C

E

14

Ligand gated
A. Kainate receptor only
B. NMDA receptor only
C. Quisqualate / AMPA receptor only
D. A and B
E. A, B, C

E

15

Voltage gated
A. Kainate receptor only
B. NMDA receptor only
C. Quisqualate / AMPA receptor only
D. A and B
E. A, B, C

B

16

Blocked by magnesium ions
A. Kainate receptor only
B. NMDA receptor only
C. Quisqualate / AMPA receptor only
D. A and B
E. A, B, C

B

17

Which of the following is true of acetylcholine (ACh) release from the neuromuscular junction?
A. One molecule of ACh equals 10000 quanta
B. One quanta contains 10000 moleculs of ACh
C. One quanta equals one molecule of ACh.
D. One vesicle contains 10000 quanta
E. One vesicle contains 10 molecules

B

18

Pro-opionimelanocortin is a precursor of
1. ACTh
2. Alpha-MSH
3. Beta-Endorphin
4. Beta-lipotropin
(A.123; B13; C24; D4; EAll of the above)

E

19

Removal of calcium ions from the cytosol in a presynaptic nerve terminal following an action potential is thought to occur by
1. Active transport
2. Binding to cytosolic proteins
3. Transport into intracellular calcium-storage vesicles
4. Reversal of flow through voltage-gated ion channels
(A.123; B13; C24; D4; EAll of the above)

A

20

Each of the following occurs in phototransduction EXCEPT
A. Activated rhodopsin activates a G-protein
B. Activation of cGMP phosphodiesterase increases hydrolisis of cGMP to 5'GMP
C. Current through a cGMP activated sodium channel decreases
D. Rhodopsin is activated when light converts bound 11-cis-retinal to all-trans-retinal
E. The decreased concentration of cGMP results in depolarization of the plasma membrane

E

21

Each of the following is true of G-proteins EXCEPT
A. Each G-protein is regulated by only one type of receptor
B. Each G-protein may regulate multiple effectors
C. The alpha subunit binds GTP
D. The Beta and gamma subunits help anchor the alpha subunit to the plasma membrane
E. The Beta and Gamma subunits modulate GDP/GTP exchange

A

22

D1 receptors act by this second messenger
A. Calcium
B. DAG
C. cAMP
D. cGMP
E. IP3

C

23

Increased by nitric oxide
A. Calcium
B. DAG
C. cAMP
D. cGMP
E. IP3

D

24

Hydrolyzed by phospholipase C
A. Calcium
B. DAG
C. cAMP
D. cGMP
E. IP3

E

25

Synergistically activates protein kinase C with calcium
A. Calcium
B. DAG
C. cAMP
D. cGMP
E. IP3

B

26

Binds to calmodulin
A. Calcium
B. DAG
C. cAMP
D. cGMP
E. IP3

A

27

Photoreception utilizes this second messenger
A. Calcium
B. DAG
C. cAMP
D. cGMP
E. IP3

D

28

Opens a calcium channel in the endoplasmic reticulum releasing free calciuminto the cytosol
A. Calcium
B. DAG
C. cAMP
D. cGMP
E. IP3

E

29

Each of the following is true of the Na/K pump EXCEPT that it
A. Contributes to the resting potential of the cell
B. Hyperpolarizes the membrane
C. Is electrogenic
D. Transports three Na ions out for two K ions in
E. Utilizes two molecules of ATP for every three Na ions transported

E

30

Each of the following is true of events occurring during the action potential EXCEPT:
A. A sudden increase in conductance of Na results in depolarization
B. Chloride permeability increases during depolarization
C. During hyperpolarization the conductance of Na is lower than normal and the conductance of K is higher than normal
D. The decrease in NA permeability occuring as the action potential reaches a peak, results from inactivation of Na channels
E. The presence of voltage dependent K channels is to allow faster repolarization

B