Dementia

Question 1

What is it ?

Answer 1

irreversible syndrome with memory loss, personality change + reduced daily functioning.

Question 2

four cognitive symptoms of dementia ?

Answer 2

Memory loss, disorientation, lack of concentration, and difficulty with speech

Question 3

non-cognitive symptoms of dementia ?

Answer 3

Agitation, aggression, distress, and psychosis.

Question 4

first-line drug for mild-to-moderate Alzheimer’s?

Answer 4

Donepezil 5mg OD for 1 month then increased to 10 mg at bedtime.

Question 5

When is donepezil potentially inappropriate
? (Contraindicated )

Answer 5

Patients with Bradycardia OR Heart block

Question 6

MOA of rivastigmine ?

Answer 6

reversible, non-competitive inhibitor of acetylcholinesterase. This increases Acetylcholine (Needed for memory/cognitive function)

Question 7

Usual dose given of Rivastigmine ?

Answer 7

1.5mg BD`

Question 8

When is memantine used for in dementia?

Answer 8

Moderate-Severe Alzheimer’s (Glutumate receptor antagonist) reduces excess brain activity