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N - Demyelinating diseases > Demyelinating > Flashcards

Flashcards in Demyelinating Deck (9)
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MS

incomplete ring enhancement is strongly suggestive of MS

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MS

Dawson fingers: radiating periventricular white matter lesions

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31 yoF

CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy)

 

lacunar and subcortical white-matter strokes and vascular dementia in younger patients.

 

It is an autosomal dominant disorder (NOTCH3 gene).

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CADASIL inheritance 

It is an autosomal dominant disorder (NOTCH3 gene).

 

mutation results in stenosis of small to medium perforating vessels and causes fibrotic thickening of the basement membranes with deposition of granular osmiophilic material around vascular smooth muscles. 

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CADASIL clinical picture

Symptoms first occur in the third and fourth decades and typically include recurrent transient ischemic attacks (TIA) and strokes across multiple vascular territories.