Demyelinating Flashcards
(9 cards)
6
Q
A
7
Q
31 yoF
A
CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy)
lacunar and subcortical white-matter strokes and vascular dementia in younger patients.
It is an autosomal dominant disorder (NOTCH3 gene).
8
Q
CADASIL inheritance
A
It is an autosomal dominant disorder (NOTCH3 gene).
mutation results in stenosis of small to medium perforating vessels and causes fibrotic thickening of the basement membranes with deposition of granular osmiophilic material around vascular smooth muscles.
9
Q
CADASIL clinical picture
A
Symptoms first occur in the third and fourth decades and typically include recurrent transient ischemic attacks (TIA) and strokes across multiple vascular territories.
