Dentin Pulp Complex II Flashcards Preview

**Oral Biology > Dentin Pulp Complex II > Flashcards

Flashcards in Dentin Pulp Complex II Deck (81):
1

What is the living, highly cellular core of the tooth?

Dental pulp

2

What is the primary cell type of the Dental pulp?

Fibroblasts followed by odontoblasts

3

What is the embryonic origin of the dental pulp?

Arises from the dental papilla, ectomesenchymal tissue

4

What are the support structures for the mineralized components of the tooth found in the dental pulp?

1. Blood vessels
2. Enervation
3. Fibroblasts
4. Pool of immune cells
5. Pool of pregenitor cells for replacement and repair

5

What are the 4 histological zones of dental pulp from outer to inner?

1. Odontoblast layer
2. Cell free zone of Weil
3. Cell rich (cell dense zone)
4. Pulp core

6

The Extracellular matrix of the dental pulp contains which types of collagen?

-Mostly Collagen III
-Also some Collagen I

7

The Dental pulp ECM is a soft ______ matrix

connective tissue

8

T/F The dental pulp ECM contains numerous non collagenous proteoglycans and glycoproteins

TRUE

9

What happens to the make up of the pulp ECM with age?

-Collagen content increases
-Fibrils aggregate into larger bundles

*Greatest concentration apically

10

The ground substance of the pulp will contain what?

1. Proteoglycans (GAG chains)
2. Glycoproteins
3. Water (physiological fluid)

11

List the 5 common proteoglycans found in the pulp

1. Chondroitin-6-sulfate
2. Chondroitin-4-sulfate
3. Heparin Sulfate
4. Dermatan sulfate
5. Keratan sulfate

12

What is the key dentin-pulp complex cell type?

Odontoblasts

13

Odontoblasts are _______ cells which have their ______ toward the pulpal side of the cell and their _______ towards the dentinal side

1. Polarized
2. Elongated nucleus
3. Secretory components (Golgi Bodies)

14

Where would Odontoblasts be larger and more columnar?

In the crown

15

Where would odontoblasts be more cuboidal?

Toward the root

16

Odontoblasts form a discrete layer of cells held together by ________

Junctional complexes

*Adherans junctions not zonular

17

T/F Odontoblasts can form gap junctions with pulpal fibroblasts

TRUE

18

Because of the way they are held together, Odontoblasts cell layers may have a degree of ________ through which _______ may pass

1. permeability
2. serum proteins

19

Odontoblasts function to create and maintain _____ and are supported by __________

1. Dentin
2. The rest of the pulp

20

Odontoblasts produce and secrete what kinds of proteins?

Collagen and Non-collagenous

21

T/F Odontoblasts produce and sequester key growth factors in dentin matrix

TRUE

22

Give 4 examples of key growth factors that come from odontoblasts

1. VEGF
2. TGF-beta-1
3. BMP-2

23

At what location on the cell do odontoblasts release secretory vesicles?

Primarily found in the OD process

24

The release of secretory vesicles from OD process continues throughout the lifespan of the OD, forming _________

Peritubular dentin

25

What are some distinct characteristics of aged odontoblasts?

1. Fewer organelles
2. Less secretory activity
3. Nucleus somewhat more central

26

Describe OD turnover

-Assumed to be long lived
-Can be replaced from mesenchymal progenitor pool

27

OD turnover is key to what?

Responsiveness of tooth and capacity for self repair

28

Odontoblasts communicate with what other cells?

1. Fibroblasts
2. Nerve cells
3. Immune cells of the pulp

29

How far do the OD processes extend?

-Not agreed upon
-Possibly all the way to the DEJ
-Prehaps only around 1/3 of the way into the dentin

30

Sequestered GFs in the dentin matrix play a role in what?

Recruitment of new OD

31

What is the predominant cell type found in dentin-pulp complex?

Fibroblasts

32

Where do you find fibroblasts in the dentin-pulp complex?

Found in the pulp core and cell rich zone

33

What do Fibroblasts do for the dentin-pulp complex?

Produce and maintain the supportive matrix of the pulpal tissue

34

The pulpal tissue matrix that is supported by the fibroblasts supports what?

1. Progenitor cells
2. Immune cells
3. Vasculature
4. Lymph
5. Nervous tissues

35

T/F Fibroblasts may have a role in facilitating mesenchymal progenitor cell recruitment and differentiation

TRUE

36

Mesenchymal progenitor cells are present where?

in dental pulp

37

In response to ______, mesenchymal progenitor cells are recruited to form ________

1. Damage
2. New Ondontoblast-like cells

38

Dental pulp progenitor cells are involved in ________

Reparative dentin formation

39

As far as immune cells go, _______ are present in the dental pulp as part of innate immunity

Macrophages

40

Healthy pulp has a key role in ________

cell turnover and clearance

41

Healthy pulp has involvement in __________

Immune response to infection

*IL-1B, TNF-a

42

Concerning Adaptive immunity, what type of cells can be found in the pulp?

Dendritic cells

43

Where are the dendritic cells found in the pulp?

Under the odontoblast layer

44

T/F T and B lymphocytes are also in the pulp

TRUE

*especially in infected pulp

45

Dendritic cells are especially closely related with what components of the pulp?

Neuronal and vascular

**has to do with coordinated tissue responses

46

Where does pulp vascular supply arise from?

External carotid arteries and superior/inferior alveolar arteries

47

_______ arterioles per root access the pulp through the _______ and spreads upward into the coronal pulp

1. 4-8
2. Apical foramen

48

What is the progression of blood supply in the pulp?

1. Arterioles
2. Capillaries
3. Venules

49

As arterioles proceed into the pulp, _________ increases, _________ decreases

1. Caliber
2. Vessel wall

50

Capillaries network is present where?

In the cell free zone

*during dentin formation present in the odontoblast layer

51

Venules leave the apical foramen and connect to ______ and drain ultimately into _______

1. Superior and inferior alveolar veins
2. Internal jugular vein

52

What does it mean for the lymphatic supply to be in a steady state in the pulp?

Lymph flow is equal to arterial interstitial flow

53

Describe the lymphatic vessels in the pulp

Thinner walls, epithelial lining and smooth muscle layer

54

What do lymph vessels do for the pulp?

Drain vascular exudate, interstitial fluid out of the pulp

55

Nerve fibers branch out through the coronal pulp forming what?

The plexus of Raschkow

56

T/F Plexus of Raschkow are most present in root pulp

FALSE They don't exist in root pulp, only branches of nerve fibers

57

Afferent nerve fibers to the pulp come from where?

Trigeminal

58

Sympathetic branches in the pulp come from where?

Cervical Ganglion

59

What does the innervation of the pulp function to do?

-Control blood flow
-Nociception
-Maybe immune response

60

The nerves in the pulp run in close contact with ______

Blood vessels

61

Nerve bundles in the pulp consist of which type of axons?

-Myelinated (Adelta)
-Unmyelinated (C)

62

Myelination decreases as fibers proceed towards the ________

Coronal pulp

63

Some unmyelinated nerve axons pass into __________ and are closely associated with ________

1. Dentinal tubules
2. Odontoblasts

64

What is the role of the nerve axons that run up into the dentinal tubules?

No clear understanding of their role

65

What are the 3 proposed models of dentin sensitivity?

1. Direct innervation
2. Odontoblast nociception
3. Tubule fluid conductance (hydrodynamic)

66

What is the thought behind Direct innervation for dentin sensitivity?

There are nerves in some tubules, but a minority

67

What is the thought behind Odontoblast nociception causeing dentin sensitivity?

Odontoblasts are neural crest cerived buta natomically do not synapse extensively with pulpal nerves; gap junctions exist however

68

What is the though behind Tubule fluid conductance in dentin sensitivity?

Local anesthetics applied to exposed dentin ineffective, changes in fluid levels can cause sensitivity

69

What is a pulp stone?

Mineralized tissue formed inappropriately in the pulp

70

What is a "free" pulp stone?

Surrounded by soft pulp tissue

71

What is an "attached" pulp stone?

Bound to dentin or embedded in secondary dentin

72

What is a "true" pulp stone?

-Containing tubules and associated wit odontoblast-like cells (rare)

73

What is a "false" pulp stone?

-Consisting of atubular mineralized tissue, sometimes with necrotic tissue at the center

* these are more common

74

T/F Pulp Stones can grow large enough to compress pulp and make debridement difficult

TRUE

75

Where do pulp stones occur?

Around collagen fibers, dead cell aggregates to thrombi

76

Pulp stones are more prevalent after how many years of life?

50

77

As you age, what causes recession of the pulp?/

Secondary dentin formation


*reduction in cell number (pulp cells I think)

78

What happens to the cell response to stimuli as you age?

It decreases

79

What happens to pulp permeability as you age?

It decreases
-Peritubular occlusion

-leads to more brittle teeth

80

In aged pulp there is a loss of _______ which leads to a decrease in _________

1. Nerve axons
2. Sensitivity

81

What happens in the central pulp as you age?

Dystrophic Calcification