dentine and pulp complex Flashcards

(37 cards)

1
Q

what is found in dental pulp?

A
  • cells
    > odontoblasts
    > fibroblasts
    > defence cells
- extracellular components
> fibres 
~ collagen 
~ oxytalan
> matrix 
~ proteoglycans 
~ chondroitin
~ dermatan
  • nerves
    > sensory, autonomic
  • blood vessels
  • lymphatics
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2
Q

name the layers of dentine-pulp complex

A
dentine 
predentine
odontoblasts
cell free zone
cell rich zone
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3
Q

what are the functions of the dental pulp?

A
  • nutritive (blood vessels)
  • dentine growth / physiological growth
    > primary
    > secondary
  • dentine repair
    > tertiary
  • defence
    > immune cells
    > lymphatics
  • neural
    > sensory
    ~ pain
    > control of dentinogenesis
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4
Q

what are the developmental links between dentine and pulp?

A

dentine and pulp develop from the dental papilla

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5
Q

what are the structural links between dentine and pulp?

A
- pulpal elements extend into dentine
> odontoblast processes
> nerve terminals
> immune cells (dendritic cells)
> dentinal fluid 
[note there are no blood vessels in normal dentine]
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6
Q

what are haemodynamics?

A

the dynamics of blood flow

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7
Q

what are hydrodynamics?

A

the branch of science concerned with forces acting on or exerted by fluids (especially liquids)

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8
Q

where does the fluid that leaks from the pulp capillaries go?

A

interstitial space

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9
Q

what are the ways in which this fluid can leak?

A

some drains by lymphatics
some passes along dentinal tubules
{look at diagram in lecture maybe for explanation on the outward tubular fluid flow}

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10
Q

what is the dentinal fluid flow proportional to?

A

pulp pressure

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11
Q

what are the functional links between dentine and pulp?

A
  • formation of secondary dentine
  • formation of tertiary dentine in response to tooth wear
    > reactionary dentine
    > reparative dentine
  • regulate exchange of material between dentine and pulp
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12
Q

name 6 things that cause tooth wear

A
  • mastication / abrasion
  • bruxism / attrition
  • abfraction / occlusal overload
  • diet = erosion
  • caries
  • operative procedures (cavity cutting and crown prep)
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13
Q

define abrasion

A

the process of scraping or wearing something away

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14
Q

define bruxism

A

involuntary habitual grinding of the teeth, typically during sleep

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15
Q

define attrition

A

the process of reducing something’s strength or effectiveness through sustained attack or pressure

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16
Q

define abfraction

A

is the mechanical loss of tooth structure that is not caused by tooth decay, located along the gum line

17
Q

what are the 2 types of tertiary dentine

A

reactionary

reparative

18
Q

what is reactionary dentine

A

it is laid down in response to a mild stimulus

laid down by primary odontoblasts

19
Q

what is reparative dentine

A

it is laid down in response to a severe stimulus which destroys the primary odontoblasts
laid down by secondary odontoblasts

20
Q

explain the odontoblast layer as a permeability barrier

A

separates pulp and tubular space

Regulates movement of material between pulp and tubular ECF, Movement can be in either direction

21
Q

what material is exchanged from the pulp to the dentine

A
  • nutrients
  • formation of secondary and tertiary dentine
  • function of tubular nerves eg potassium for membrane potential
22
Q

what material is exchanged from the dentine to the pulp

A
  • medicaments applied to dentine
  • diffusion of toxins from bacteria
  • diffusion of components from filling materials
23
Q

what is the anatomy of pulp nerves

A

branches of alveolar nerves

  • neurovascular bundles enter pulp via apical foramen
  • pass along root canal in centre of pulp towards coronal pulp chamber
  • branches fan out in sub-odontoblastic layer = Raschow’s plexus
  • terminal branches enter odontoblast layer, some nerves enter dentinal tubules
24
Q

explain the innervation of dentine

A
some nerves enter dentine
	- Under cusps
		○ 40% of tubules contain nerves
		○ Some axons extend around 100-200 micrometres
	- Coronal dentine
		○ Less; around 15%
	- Root dentine 
		○ As little as 4%
Few axons enter tubules, most end in pre-dentine region
25
what is the hydrodynamic mechanism for activating intradental sensory nerves?
1. stimulus (can be thermal, mechanical, evaporative, chemical) acts on exposed dentine - open tubules 2. this increases the rate of dentinal fluid flow 3. causes generation of action potentials in intra-dental nerves 4. action potentials pass to brain to cause pain
26
what generates an outward dentinal fluid flow
- cooling - drying - evaporating - hypertonic solutions - decreased hydrostatic pressure
27
what generates an inwards dentinal fluid flow
- heating - mechanical - increased hydrostatic pressure
28
is outward or inward fluid flow more effective at activating intradental nerves
outward - away from the pulp | rapid outward flow stretches the nerves
29
what stimuli bypass the hydrodynamic mechanism and act directly on intradental nerves?
- Intense heating - Intense cooling - Electrical current (vitality tests) - Pain producing chemicals
30
what mediates normal dentinal sensitivity
a-beta and a-alpha fibres | Activated by hydrodynamics stimuli applied to dentine
31
what mediates pain associated with pulp inflammation
c fibres activated directly by stimuli, rather than hydrodynamic mechanism They respond to most forms of intense stimulatio
32
what is the blood supply to the teeth
branches of maxillary arteries
33
what controls pulp blood flow
- local factors > metabolites - nerves > sympathetic > somatic afferents - circulating hormones > adrenaline - drugs > LA preparations with vasoconstrictors
34
what are the functions of pulp nerves
- sensory > mediating pain ``` - control of BV > sympathetic ~ vasoconstrictor > afferents ~ vasodilator ``` - promote neurogenic inflammation > neuropeptides ~ Subst P ~ CGRP - promote dentine formation - maybe facilitate an immune response
35
explain the dentine-pulp response to injury
``` • Immediate ○ Nociceptor activation = pain • After 1 minute or so ○ Early inflammatory response ○ Kinins, prostaglandins, neuropeptides ○ Vasodilation • After 10 minutes or so ○ Nociceptor sensitisation ○ Extravasation of fluid, oedema ○ Polymorph migration • After 100 minutes or so ○ Enzyme activation; Nerve growth factor ○ Monocyte presence • After 1 day or so ○ Nerve sprouting (NGF) ○ Increased axonal transport ○ Altered excitability of CNS synapses • After 1 week or so ○ Repair; tertiary dentine formation • Variable Completion of repair and recovery ```
36
what is pulpitis
acute inflammation in the dental pulp
37
why is pulpitis different to inflammation in other tissues
the pulp cannot swell within the pulp chamber | oedema causes an increase in pulp pressure