Depression Flashcards
Drug induce depression (5A, BC)
Antipsychotic Anti-parkinson Anticonvulsant Anticholinergic Antiviral Bb CCB Clonidine Corticosteroids Finasteride Interpheron alpha/beta Isotretinoin Methyldopa PPI and H2RA Reserpine Stimulant Statins Sex hormones Triptans Varenicline
Screening tools available for depression:
- Patient health questionnaire
- Mood disorder questionnaire
- HAM-D-7 (hamilton depression rating scale)
- EPDS (edinburg postnatal depression scale)
4 superior efficacy 1st line pharmacological treatment for depression: (SeVeM-Es)
Sertraline
Venlafaxine
Mirtazapine
Escitalopram
Primary metabolizing CYP enzyme for citalopram and escitalopram:
2C19 3A4
Primary metabolizing CYP enzyme for fluoxetine
2C9 2D6
Primary metabolizing CYP enzyme for fluvoxamine
1A2 2D6
Primary metabolizing CYP enzyme for Paroxetine IR and CR
2D6
Primary metabolizing CYP enzyme for sertraline
2D6
Primary lnhibitory CYP enzyme for fluoxetine
2C9
2C19
2D6
3A4
Primary inhibitory CYP enzyme for fluvoxamine
1A2
2C9
2C19
3A4
Primary inhibitory CYP enzyme for paroxetine
2D6
Primary inhibitory CYP enzyme for sertraline
2C19
2D6
Primary inhibitory CYP enzyme for duloxetine
2D6
Primary metabolizing CYP enzyme for venlAfaxine, desfenlAfaxine and levomilnAcipran
CYP 3A4
Primary metabplizing CYP enzyme for bupropion
CYP 2B6
