Depression Flashcards
(23 cards)
Drug induce depression (5A, BC)
Antipsychotic Anti-parkinson Anticonvulsant Anticholinergic Antiviral Bb CCB Clonidine Corticosteroids Finasteride Interpheron alpha/beta Isotretinoin Methyldopa PPI and H2RA Reserpine Stimulant Statins Sex hormones Triptans Varenicline
Screening tools available for depression:
- Patient health questionnaire
- Mood disorder questionnaire
- HAM-D-7 (hamilton depression rating scale)
- EPDS (edinburg postnatal depression scale)
4 superior efficacy 1st line pharmacological treatment for depression: (SeVeM-Es)
Sertraline
Venlafaxine
Mirtazapine
Escitalopram
Primary metabolizing CYP enzyme for citalopram and escitalopram:
2C19 3A4
Primary metabolizing CYP enzyme for fluoxetine
2C9 2D6
Primary metabolizing CYP enzyme for fluvoxamine
1A2 2D6
Primary metabolizing CYP enzyme for Paroxetine IR and CR
2D6
Primary metabolizing CYP enzyme for sertraline
2D6
Primary lnhibitory CYP enzyme for fluoxetine
2C9
2C19
2D6
3A4
Primary inhibitory CYP enzyme for fluvoxamine
1A2
2C9
2C19
3A4
Primary inhibitory CYP enzyme for paroxetine
2D6
Primary inhibitory CYP enzyme for sertraline
2C19
2D6
Primary inhibitory CYP enzyme for duloxetine
2D6
Primary metabolizing CYP enzyme for venlAfaxine, desfenlAfaxine and levomilnAcipran
CYP 3A4
Primary metabplizing CYP enzyme for bupropion
CYP 2B6
Primary metabolizing CYP enzyme for mirtazapine
CYP 1A2
2D6
3A4
1st metabolizing CYP enzyme for Amitryptyline
3A4
2C19
1st metabolizing CYP enzyme for clomipramine
2D6
1st metabolizing CYP enzyme for desipramine
2D6
2C19
1st metabolizing CYP enzyme for Doxepin
2D6
1st metabolizing CYP enzyme for Imipramine
2D6
3A4
1st metabolizing CYP enzyme for Nortryptyline
3A4
SsRI drugs
Citalopram Escitalopram Fluoxetine Fluvoxamine Paroxetine Sertraline
