Mental Health Drugs

Question 1

MOA of SSRI

Answer 1

Bind to SERT, inhibits serotonin reuptake

Question 2

Side effects of SSRI:

Answer 2

Headache
Fatigue
Orthostatic hypotension
Insomnia
GI effects
(Abdominal pain
Constipated
Decrease/increase appetite
Dyspepsia)
Ach effects
Sexual dysfunction
Agitation

Question 3

SSRI interacts with:

Answer 3

MAOi

NSAIDS & antiplatelets (increase risk of bleeding)

Question 4

SSRI inhibits which enzymes?

Answer 4

CYP 450

Question 5

SNRI Moa:

Answer 5

Inhibits reuptake of serotonin and NE

Question 6

SE of SNRI

Answer 6

Headache
Insomnia
Sweating😰
🤢
Dry mouth
Sexual dysfunction
Sleepiness

Question 7

SNRI interactions:

Answer 7

SS with Maoi

Question 8

Don’t use this SNRI drug if HTN if uncontrolled and the dose is above 225mg

Answer 8

Venlafaxin

Question 9

This dual action drug inhibita the reuptake of NE and Dopamine

Answer 9

Bupropion

Question 10

SE of bupropion:

Answer 10

Agitation
Anxiety
Insomnia
Pruritis
Nausea
Increase seizures
Decrease appetite
Seizure disorder
Anorexia
Bulimia nervosa
Electrolyte disturbance

Question 11

If bupropion interacts with Maoi, what would be the result?

Answer 11

Increase cyclophosphamide levels

Question 12

This dual action drug stimulated NE and serotonin release and inhibita 5HT2 and 5HT3 receptors

Answer 12

Mirtazapine

Question 13

SE of mirtazapine

Answer 13

Weight gain
Dry mouth
Sedation
Increase serum cholesterol
Xerostomia
Increase appetite
Constipation

Question 14

Serotonin modulator drugs are?

Answer 14

Trazodon
Vilazodone
Vortioxetine

Question 15

This drug is potent serotonin receptor antagonist and weak serotonin reuptake inhibitor

Answer 15

Trazodone

Question 16

Major SE of trazodone:

Answer 16

Orthostasis
Blurred vision
Xerostomia

Question 17

Trazodone should be avoided with

Answer 17

Maoi
CNS depressants
Antihypertensive agents

Question 18

Trazodone is CI with which enzyme inhibitor

Answer 18

3A4

Question 19

The MOA of this drug is serotonin modulation and transporter inhibition

Answer 19

Vortioxetine

Question 20

MO OF tCA drugs

Answer 20

Serotonin-NE reuptake inhibitor

Question 21

What tyoe of drugs should be avaoided with TCA?

Answer 21

Anticholinergic drugs
Cns depressants
MaoI (fatal)
SSRI/SNRI

Question 22

It is a reversible MAOa inhibitor

Answer 22

Moclobemide

Question 23

These are non-selective MAOa and MAOb inhibitors

Answer 23

Phenelzine

Tranylcypromide

Question 24

Washout period from MAOI to other antidepressants

Answer 24

14 days

Question 25

Washoit period from moclobemide to other antidepressants

Answer 25

5days

Question 26

Washoit period from MAOI TO MaoI

Answer 26

4 days

Question 27

SE if MAOi

Answer 27

``` Insomnia Palpotations Tachycardia Orthostatic hypotension Sexual dysfunction(phenelazine and tranylcypromide) Cardiac effects ```

Question 28

What tyoe of food should be avoided with irreversible MAOI?

Answer 28

Tyramine rich food

Question 29

Drugs that should be avoided with MAOI?

Answer 29

Sympathomimetic drugs Levodopa Other seratonergic druga

Question 30

MOA of Olanzapine

Answer 30

5HT2 and D1234 dopamine receptor antagonist

Question 31

Olanzapine interacts with:

Answer 31

Metabolizing enzyme CYP450/1A2/2D6 Fluvoxamine, fluoxetine, ciprofloxacin Omeprazole Smoking

Question 32

MOA of quetiapine

Answer 32

Inhibits 5HT2 and D1,2 receptors

Question 33

Quetiapine interacts with:

Answer 33

Cns depressants Cyp3A4 inhibitors/inducers Avoid PGP transporter inhibitors/inducers

Question 34

Moa of risperidone

Answer 34

Combined antagonist activity at D2 receptor and 5HT2 serotonin receptor

Question 35

Se of Risperidone

Answer 35

EPS ORTHOSTATIC HYPOTENSION HYPERPROLACTINEMIA WEIGHT GAIN

Question 36

Risperidone interacts with:

Answer 36

Carmabazepine | Cyp2D6 inducers/inhibitions