depression

Question 1

TCA examples

Answer 1

amitriptyline, imipramine, dothiepin, clomipramine

Question 2

TCA moa

Answer 2

blocks reuptake of NE & 5HT.
- antichol
- H1 & alpha adrenergic antagonism

Question 3

classes causing GI and sexual dysfunction

Answer 3

TCA, SSRI

Question 4

ssri examples

Answer 4

fluoxetine, fluvoxamine, escitalopram, sertraline, paroxetine

Question 5

ssri/snri se

Answer 5

gi and sexual dysf
transient nervousness during initiation
hyponatremia (SIADH)
risk of bleeding

Question 6

ssri moa

Answer 6

selective blocking of 5ht

Question 7

tca se

Answer 7

FATAL ON OVERDOSE
- gi & sexual dysfunction
- antichol
- sedation
- weight gain
- orthostatic hypot
- arrythymia
- seizure

Question 8

paroxetine

Answer 8

short t1/2 (leads to highest withdrawal syndrome), sedating, weight gain

Question 9

mirtazapine moa

Answer 9

alpha 2 adrenoceptor antagonist
antagonist of H1 and 5HT2/3

Question 10

mirtazapine se

Answer 10

somnolence, increased appetite, weight gain

Question 11

mirtazapine benefit

Answer 11

reversal of gi and sexual se of SSRI/SNRI

Question 12

snri examples

Answer 12

venlafaxine, desvenlafaxine, duloxetine

Question 13

bupropion moa

Answer 13

blocks reuptake of ne & da

Question 14

bupropion se

Answer 14

seizure, insomnia, psychosis

Question 15

bupropion avoid in

Answer 15

eating disorders, seizures, psychosis

Question 16

bupropion benefit

Answer 16

decrease sexual se of SSRI/SNRI, smoking cessation

Question 17

moclobemide moa

Answer 17

reversible maoi-a

Question 18

duloxetine benefit

Answer 18

diabetic neuropathy, chronic MSK pain

Question 19

adjunctive tx

Answer 19

second generation antipsych: aripiprazole, brexpiprazole, quetiapine

Question 20

herbal-drug interactions

Answer 20

st john wart

Question 21

neuropathic pain preferred agents

Answer 21

amitriptyline, nortriptyline

Question 22

when switching from maoi to other antidep, washout?

Answer 22

24h

Question 23

when switching from other antidep to maoi, washout?

Answer 23

at least 1 week

Question 24

what does hyponatremia result in

Answer 24

siadh - urinary retx/seizures

Question 25

preferred antidep for late pregnancy

Answer 25

nortriptyline

Question 26

preferred antidep for breastfeeding

Answer 26

mirtazapine, sertraline

Question 27

preferred antidep for bipolar depression

Answer 27

lithium, lamotrigine, quetiapine

Question 28

what drugs to avoid in elderly

Answer 28

tca, antichol, hypoT

Question 29

top counselling points

Answer 29

suicidality risk (under 24) not to mix concurrent usage of alcohol with drug

Question 30

antidep causing weight gain

Answer 30

mirtazapine

Question 31

drugs causing serotonin syndrome with ssri/snri

Answer 31

triptans, opioids, linezolid, MAOi

Question 32

bleeding risk with which medication

Answer 32

ssri

Question 33

antideps which are cyp2d6 inhibitors

Answer 33

fluox parox bupropion

Question 34

fluvoxamine inhibitor of ?

Answer 34

1a2, 2c19

Question 35

common drugs that are substrates of 2d6

Answer 35

metoprolol, codeine, tramadol

Question 36

warfarin is a substrate of?

Answer 36

2c19,1a2

Question 37

antideps with fever cyp interactions

Answer 37

mirtazapine, escitalopram, venlafaxine, vortioxetine

Question 38

symptoms of antidep discontinuation syndrome

Answer 38

Flu Insomnia Nausea Imbalance Sensory disturbances Hyperarousal

Question 39

antideps with long half lives

Answer 39

fluoxetine, bupropion

Question 40

antideps that can reduce se of sexual function

Answer 40

mirtazpine, bupropion, agomelatine

Question 41

which drug can worsen htn

Answer 41

venlafaxine

Question 42

medical disorders predisposing to depression

Answer 42

hypothyroidism, t2dm, cad, chf, mi, electrolyte imbalances

Question 43

psychiatric disorders predisposing to depression

Answer 43

anxiety, eating disorders, schizophrenia

Question 44

recite INSADCAGES

Answer 44

Interest Sleep: insomnia/hypersomnia (minimally needs 3 hours, otherwise maybe bipolar mania) Appetite / weight loss Depressed (Adults) / irritable (children) Concentration Activity Guilt Energy (fatigue) Suicidal thoughts/attempts

Question 45

duloxetine se

Answer 45

urinary retention

Question 46

first line for suicidality risk

Answer 46

lithium

Question 47

how long is the acute phase trial for antideps

Answer 47

4-8 weeks

Question 48

agomelatine cyp

Answer 48

1a2