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pr 3153 > depression > Flashcards

depression Flashcards

1
Q

TCA examples

A

amitriptyline, imipramine, dothiepin, clomipramine

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2
Q

TCA moa

A

blocks reuptake of NE & 5HT.
- antichol
- H1 & alpha adrenergic antagonism

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3
Q

classes causing GI and sexual dysfunction

A

TCA, SSRI

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4
Q

ssri examples

A

fluoxetine, fluvoxamine, escitalopram, sertraline, paroxetine

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5
Q

ssri/snri se

A

gi and sexual dysf
transient nervousness during initiation
hyponatremia (SIADH)
risk of bleeding

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6
Q

ssri moa

A

selective blocking of 5ht

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7
Q

tca se

A

FATAL ON OVERDOSE
- gi & sexual dysfunction
- antichol
- sedation
- weight gain
- orthostatic hypot
- arrythymia
- seizure

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8
Q

paroxetine

A

short t1/2 (leads to highest withdrawal syndrome), sedating, weight gain

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9
Q

mirtazapine moa

A

alpha 2 adrenoceptor antagonist
antagonist of H1 and 5HT2/3

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10
Q

mirtazapine se

A

somnolence, increased appetite, weight gain

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11
Q

mirtazapine benefit

A

reversal of gi and sexual se of SSRI/SNRI

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12
Q

snri examples

A

venlafaxine, desvenlafaxine, duloxetine

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13
Q

bupropion moa

A

blocks reuptake of ne & da

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14
Q

bupropion se

A

seizure, insomnia, psychosis

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15
Q

bupropion avoid in

A

eating disorders, seizures, psychosis

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16
Q

bupropion benefit

A

decrease sexual se of SSRI/SNRI, smoking cessation

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17
Q

moclobemide moa

A

reversible maoi-a

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18
Q

duloxetine benefit

A

diabetic neuropathy, chronic MSK pain

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19
Q

adjunctive tx

A

second generation antipsych: aripiprazole, brexpiprazole, quetiapine

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20
Q

herbal-drug interactions

A

st john wart

21
Q

neuropathic pain preferred agents

A

amitriptyline, nortriptyline

22
Q

when switching from maoi to other antidep, washout?

A

24h

23
Q

when switching from other antidep to maoi, washout?

A

at least 1 week

24
Q

what does hyponatremia result in

A

siadh - urinary retx/seizures

25
Q

preferred antidep for late pregnancy

A

nortriptyline

26
Q

preferred antidep for breastfeeding

A

mirtazapine, sertraline

27
Q

preferred antidep for bipolar depression

A

lithium, lamotrigine, quetiapine

28
Q

what drugs to avoid in elderly

A

tca, antichol, hypoT

29
Q

top counselling points

A

suicidality risk (under 24)

not to mix concurrent usage of alcohol with drug

30
Q

antidep causing weight gain

A

mirtazapine

31
Q

drugs causing serotonin syndrome with ssri/snri

A

triptans, opioids, linezolid, MAOi

32
Q

bleeding risk with which medication

A

ssri

33
Q

antideps which are cyp2d6 inhibitors

A

fluox
parox
bupropion

34
Q

fluvoxamine inhibitor of ?

A

1a2, 2c19

35
Q

common drugs that are substrates of 2d6

A

metoprolol, codeine, tramadol

36
Q

warfarin is a substrate of?

A

2c19,1a2

37
Q

antideps with fever cyp interactions

A

mirtazapine, escitalopram, venlafaxine, vortioxetine

38
Q

symptoms of antidep discontinuation syndrome

A

Flu
Insomnia
Nausea
Imbalance
Sensory disturbances
Hyperarousal

39
Q

antideps with long half lives

A

fluoxetine, bupropion

40
Q

antideps that can reduce se of sexual function

A

mirtazpine, bupropion, agomelatine

41
Q

which drug can worsen htn

A

venlafaxine

42
Q

medical disorders predisposing to depression

A

hypothyroidism, t2dm, cad, chf, mi, electrolyte imbalances

43
Q

psychiatric disorders predisposing to depression

A

anxiety, eating disorders, schizophrenia

44
Q

recite INSADCAGES

A

Interest
Sleep: insomnia/hypersomnia (minimally needs 3 hours, otherwise maybe bipolar mania)
Appetite / weight loss
Depressed (Adults) / irritable (children)
Concentration
Activity
Guilt
Energy (fatigue)
Suicidal thoughts/attempts

45
Q

duloxetine se

A

urinary retention

46
Q

first line for suicidality risk

A

lithium

47
Q

how long is the acute phase trial for antideps

A

4-8 weeks

48
Q

agomelatine cyp

A

1a2

pr 3153 (8 decks)

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