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pr 3153 > epilepsy > Flashcards

epilepsy Flashcards

1
Q

phenytoin/cbz moa

A

blocks voltage-depd Na+ channels, preventing sodium influx and action potential

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2
Q

indication for pht/cbz

A

all except absence seizures

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3
Q

pht cbz strong inducers of

A

cyp450

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4
Q

pk of pht

A

zero order

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5
Q

pht availability

A

highly albumin bound

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6
Q

pht ci

A

pregnancy

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7
Q

does valp cause weight gain or loss

A

gain

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8
Q

ae of CBZ

A

sjs/ten

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9
Q

what to screen prior to cbz

A

hlab-1502

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10
Q

ci of valp

A

pregnancy

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11
Q

first line for preg

A

lamotrigine

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12
Q

non dose related side effects of anticonvulsants (valp, pht, cbz)

A

hirsutism
gingival hyperplasia
folate deficiency
acne
osteomalacia
peripheral neuropathy

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13
Q

dose related side effects of anticonvulsants (pht, valp, cbz)

A

drowsiness
confusion
involuntary eye movement
slurred speech

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14
Q

valp moa

A

Blockade of voltage-dependent Na+ and Ca2+ channels

Inhibits GABA transaminase, increasing GABA

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15
Q

valp indication

A

all seizures

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16
Q

pk valp

A

highly protein bound, displaces other drugs

17
Q

levetiracetam moa

A

Affinity for binding to synaptic vesicle protein 2A

18
Q

indication of levetiracetam

A

Adjunct/
Monotherapy

  • Partial onset
  • Myoclonic
  • Primary generalised TC seizures
19
Q

benefit of leve

A

Low interpersonal variability (no monitoring needed)

20
Q

side effects of leve

A

Headache
Vertigo
Cough
Depression
Insomnia

(Agranulocytosis, suicide, delirium, dyskinesia)

21
Q

lamotrigine moa

A

Blocks voltage-depd Na+ channels

Inhibits glutamate release

22
Q

lamotrigine indication

A

Adjunct/ Monotherapy
- Partial
- Generalised (TC)
- Mono: Absence

Adjunct / initial AED: Lennox-Gastaut syndrome

23
Q

efficacy of lamo reduced with

A

cbz pht

24
Q

toxicity of lamo increased with

A

valp

25
Q

side effects of lamo

A

Headache
Irritability / aggression
Tiredness

(Agranulocytosis, hallucination, EPSE)

26
Q

topiramate moa

A

Increases GABA activation, enhances GABA induction of Cl- flux, does not increase channel opening time.

27
Q

topiramate uses

A

Monotherapy:
- Partial
- Generalised TC

Adjunct: Lennox-Gastaut syndrome

Migraine Prophylaxis

28
Q

clearance of topiramate

A

renal

29
Q

side effects of topiramate

A

Depression
Somnolence
Fatigue
Nausea
Weight loss

(Neutropenia, mania, SJS/TEN)

30
Q

Barbiturates moa

A

Potentiate GABAA mediated Cl- currents, at a site distinct from BZD

31
Q

bzd moa

A

Potentiates influx of Cl- ions → hyperpolarisation → prevents firing of neurons

32
Q

bza antidote

A

iv flumazenil

33
Q

which anticonvulsant can be used for migraine prophylaxis?

A

topiramate

pr 3153 (8 decks)

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