Depression Flashcards
(16 cards)
What is the evidence for SAMe in treatment of depression?
Good evidence that it is effective in mild-moderate depression; preliminary evidence for augmentation of SSRI therapy
SAMe is comparable to TCAs. T or F.
True
What ingredient in SJW is most active for effect and drug interactions?
Hyperforin
What is the mechanism of SJW?
- inhibits the reuptake of serotonin, NA, GABA, dopamine and L-glutamate
- increases serotonin receptors
What is the onset of action of SJW and when can you expect significant treatment effect?
Onset is 10-14days; maximum effect seen in 4-6 weeks
What is the maximum dose for SJW?
1800mg/day
Which NHP product for depression requires tapering off a patient to prevent withdrawal symptoms?
SJW
Which NHP product can cause dry mouth, insomnia, and frequent urination?
SJW
Which NHP product has case reports of causing serotonin syndrome?
SJW
What is a major drug interaction with SJW?
decreases levels of OC - unwanted pregnancy
Currently there is good evidence to support SJW as adjunct therapy in treating depression. T or F.
False
What should the ratio of EPA:DHA be for treatment of depression?
> 60% EPA
What is the evidence for omega-3 as add on therapy to SSRI?
4 small RCT showed effective
1-4g EPA + DHA daily (EPA >60%)
Which NHP product for depression has not been studied for long term safety?
SAM-e
What is the MOA of SAMe?
- increase NE and dopamine levels
- increases serotonin levels
- alters membrane fluidity to facilitate signal transmission across membrane
What is the MOA of omega-3 in depression?
- decrease levels of inflammatory eicosanoids
- increase synaptic plasticity, neurotransmission
- metabolism of monoamines
