Osteoarthritis Flashcards
(7 cards)
1
Q
Which joints are not affected by osteoarthritis?
A
Wrist, ankle, elbow
2
Q
What are the risk factors osteoarthritis?
A
Age, obesity, joint trauma, overuse, misalignment, genetic factors
3
Q
What does cartilage contain?
A
Chondrocytes that secrete aggrecan, collagen II, cytokines and growth factors
4
Q
Aggrecan
A
Major proteoglycan in the cartilage
5
Q
Aggrecans are highly _________ charged and are stiff due to _____________.
A
negatively; electrostatic repulsion
6
Q
Proteoglycan
A
Heavily glycosylated proteins
7
Q
Glycosoaminoglycan
A
Long unbranched polysaccharides found in proteoglycans such as chondroitin, keratan, hylanuronate
