Depression

Question 1

What drugs can induce depression?

Answer 1

beta blockers, reserpine

Question 2

What drugs are used in manic depressive disorders?

Answer 2

lithium, antipsychotics, antidepressants

Question 3

Which drugs are tricyclics?

Answer 3

imipramine, amitriptyline

Question 4

What drugs are the SSRI?

Answer 4

Selective serotonin reuptake inhibitors.

fluoxetine, sertraline, paroxetine, fluvoxamine, citalopram, escitalopram

Question 5

What drugs are SNRI?

Answer 5

Selective norepinephrine reuptake inhibitors

venlafaxine, duloxetine, atomoxetine

Question 6

What are the pharmacologic effects of imipramine?

Answer 6

Sedation, antidepressant effect seen in 2-4 weeks, CNS stimulation, decrease seizure threshold

Question 7

What drugs have a stimulant activity instead of sedation?

Answer 7

bupropion, venlafaxine

Question 8

What drug selectively inhibits DA reuptake?

Answer 8

bupropion

Question 9

What drug inhibits both NE and 5-HT reuptake?

Answer 9

venlafaxine

Question 10

What drugs inhibit the reuptake of 5-HT and block 5-HT2 receptors?

Answer 10

trazodone, nefazadone

Question 11

What are the anticholingeric side effects?

Answer 11

dry mouth, constipation, urine retention, loss of visual accommodation

Question 12

Which drug produces the most anticholingeric side effects?

Answer 12

amitriptyline

Question 13

What are the cardiovascular side effects?

Answer 13

postural hypotension, tachycardia, arrhythmias

Question 14

Treatment of antidepressant overdose is?

Answer 14

sodium bicarbonate

Others: CCB, BBlockers, antiarrhythmics

Question 15

What drugs can cause serotonin syndrome?

Answer 15

MAOI and tricyclic combo

wait 2-4 weeks before switching

Question 16

This drug is a tricyclic antidepressant that is more sedative and anticholinergic than imipramine.

Answer 16

amitriptyline

Question 17

These drugs have less sedation, anticholingeric, cardiovascular, weight gain than tricyclics

Answer 17

SSRI

Question 18

This drug has less potential for drug interactions than fluoxetine.

Answer 18

sertraline

Question 19

This drug is more rapidly metabolized and does not form active metabolite. it also is more likely to cause weight gain.

Answer 19

Paroxetine

Question 20

This drug is more likely to produce seizures. Also used in treatment of dependence of opiates or nicotine.

Answer 20

bupropion

Question 21

These drugs may be used for ADHD as well as depression.

Answer 21

venlafaxine, atomoxatine

Question 22

This is approved for neuropathic pain as well as depression.

Answer 22

duloxetine

Question 23

This drug can cause priapism and is very sedating.

Answer 23

trazodone

Question 24

This drug block presynpatic alpha-2 receptors. enhance Ne,Se release.

Answer 24

mirtazapine

Question 25

This drug is useful for patients with anxiety and depression.

Answer 25

mirtazapine

Question 26

This preferentially metabolizes NE and 5-HT.

Answer 26

MAO-A

Question 27

This preferentially metabolizes DA.

Answer 27

MAO-B

Question 28

This drug is a selective inhibitor of MAO-B

Answer 28

Selegeline

Question 29

What is the chronic effect of using MAOI?

Answer 29

decreased number and sensitivity of adrenergic and serotonergic receptors

Question 30

This drug can irreversibly inactivate MAO due to forming covalent bonds.

Answer 30

Phenelzine

Question 31

This drug binds very tightly to MAO.

Answer 31

tranylcypromine

Question 32

What is the greatest problem with using non-selective MAOI?

Answer 32

They interact with substances such as tyramine.

Question 33

What MAOI can be used for the treatment of parkinson's disease?

Answer 33

Selegiline

Question 34

Which drug is the most effective for treatment of manic-depressive disorders?

Answer 34

Lithium

Question 35

What is the purposed mechanism of lithium?

Answer 35

Lithium inhibits the regeneration of inositol in the phosphoinositide signaling pathway

Question 36

What antiepileptic drugs are effective in treatment of manic-depressive disorders?

Answer 36

carbamazepine, valproic acid, clonazepam