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Pharmacology > Derm > Flashcards

Derm Flashcards

1
Q

Which topical dosage form is most and least potent?

A

Foam = Least
Ointment = Most

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2
Q

Which topical dosage form is good for large areas?

A

Lotion

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3
Q

Which topical dosage form is good for hairy areas?

A

Gel

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4
Q

Most common bacteria causing Acne Vulgaris?

A

Cutibacterium acnes (C. Acnes)
2nd MC: Staphylococcus epidermidis

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5
Q

3 Topical Retinoids

A

Adapalene (Differin)
Tazarotene (Tazorac)
Tretinoin (Retin-A)

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6
Q

Topical Retinoids MOA

A

Promotes cellular turnover

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7
Q

Tank the tolerability and Efficacy of topical retinoids

A

Tolerability: Adapalene > Tretinoin > Tazarotene
Efficacy: Tazarotene > Adapalene > Tretinoin

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8
Q

Topical ABX for Acne

A

Clindamycin, Erythromycin, Dapsone

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9
Q

Dapsone + Benzoyl Peroxide = _______

A

Yellow-orange skin discoloration

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10
Q

Accutane MOA

A

Inhibit proliferation and differentiation of sebaceous cells which decreases sebum production

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11
Q

SE of Accutane

A
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12
Q

Is clindamycin a topical or oral ABX when used for acne?

A

Topical

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13
Q

1 trmnt for Psoriasis?

A

Topical corticosteroids

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14
Q

Super-high, Medium, and Least potent topical corticosteroids?

A
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15
Q

Topical Calcineurin Inhibitors Black Box Warning

A

Tacrolimus (Protopic) and Pimecrolimus
MOA: inhibits T-lymphocyte activation
Mostly used in sensitive areas
BBW: Incr risk of malignancy (skin cancer, lymphoma)

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16
Q

Methotrexate ADR

A

pancytopenia/myelosuppression, infection, renal failure, hepatotoxicity, MTX-induced lung disease, neurotoxicity

PREG CATEG X

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17
Q

Which psoriasis trmnt is nephrotoxic?

A

Systemic Calcineurin inhibitor
Cyclosporine
(Dose-related HTN & Efficacy)
(NEPHROTOXIC, incr risk of cancer)

18
Q

Which Psoriasis med is a PDE-4 inhibitor that can cause nausea/diarrhea and is a good alternative if pt does NOT want to do biologic injections?

A

Apremilast (Otezla)

19
Q

Which oral Retinoid is teratogenic and you have to wait 3 years to get pregnant after taking?

A

Acitretin

20
Q

Biologics for Psoriasis target interlukins ____, ___, ____

A

12
17
23

21
Q

Psoriasis TNF inhibitors

A

Humira
Remicade
Enbrel

22
Q

Psoriasis Non-TNF agents

A

Stelara (IL-12 & IL-23)
Cosentyx (IL-17)

23
Q

Screen for ___ before giving biologics

A

TB

24
Q

Atopic triad

A

Astha
Allergic rhinitis
Atopic Dermatitis (Eczema)

25
Q

1st line trmnt for Eczema?

A

Topical corticosterods

26
Q

Eucrisa, Opzeluraare, and Dupixent are used for

A

Eczema

27
Q

Which Eczema med is a PDE-4 inhibitor that is steroid free and safe for those 3mo+

A

Eurcrisa

28
Q

Which Eczema med is a Janus Kinase (JAK) inhibitor that is steroid free but can only be used in those 12yo+. It also has BBWs including TB, cancer risk, and clot risk

A

Opzelura

29
Q

Which Eczema med is an IL-4 Receptor antagonist and can lead to sinus/URI? This drug may also need to be stopped if there is a parasitic infx.

A

Dupixent

30
Q

Which eczema med is the oral form of a janus kinase (JAK) inhibitor?

A

Rinvoq
(Tpoical is Opzelura)

31
Q

1st line for stage 1 Hidradenitis Suppurativa (HS)?

A

Topical clindamycin

32
Q

Which topical ABX are for. G+ Bac? G- Bac?

A
33
Q

Prevention and trmnt of cold sores

A

Prevention -> Oral antiviral
Trmnt -> Topical antivirals

34
Q

Prevention and Trmnt of Shingles

A

Prevention -> Shingrix vaccine
Trmnt -> ORal antiviral, pain control

35
Q

2 trmnts for warts

A

Salicyclic acid
Cryotherapy

36
Q

Azoles MOA

A

Inhibits CYP450. End effect is inhibition of the conversion of lanosterol to ergosterol. WE DO NOT WANT ERGOSTEROL! We are removing the helper that turns Lanosterol to ergosterol. Thus, Ergosterol cannot be produced!

37
Q

Azoles anti-fungals this a serious system SE -> _____

A

Hepatotoxicity

38
Q

Antifungal alllylamines MOA

A

Inhibit equaline epoxidase
Which is needed for ergosterol production!

39
Q

Which antifungal can cause ventricular tacchycardia and hair discoloration for light hair?

A

Cicloprox

40
Q

Trmnt for superficial burns?

A

Topical ABX: polymyxin B, bacitracin, neomycin

41
Q

Trmnt for deep burns or wide-spread superifical burns?

A

Silver sulfadiazine (SSD)

42
Q

Trmnt for lice and scabies

A

Pharmacology (14 decks)

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