Derm

Question 1

Initial treatment of porphyria cutanea tarda?

Answer 1

• phlebotomy (especially advised in pts with significant iron overload or with hemochromatosis gene mutations)

or

• low-dose hydroxychloroquine or chloroquine

Question 2

what analgesia should be given when rewarming frost bite injuries?

Answer 2

ibuprofen
- may decrease vasoconstriction and additional damage to the tissue. - should be continued until frostbite injury is healed or until surgery.

Question 3

what enzyme is implicated in porphyria cutanea tarda?

Answer 3

uroporphyrinogen decarboxylase

• causes an accumulation of carboxylated porphyrinogens, which become oxidized to porphyrins