Derm Flashcards
(214 cards)
1
Q
Is Toxic Epidermal Necrolysis cell poor?
A
yes
2
Q
How many biopsies?
A
two
3
Q
What is more common, BP or PV?
A
BP
4
Q
What is the age range for BP?
A
60-80
5
Q
Which two specific antigens for BP?
A
180 and 230
6
Q
Does BP appear quickly or over time?
A
over time
7
Q
Which two immune proteins deposit during BP?
A
IgG and C3
8
Q
Systemic or topical steroids for BULLOUS Pemphigoid?
A
systemic
9
Q
Does antibody titer correlate during episodes of BP?
A
yes
10
Q
Does pemphigoid gestationis attack oral mucosa?
A
no
11
Q
Systemic or topical steroids for Pemphigoid Gestationis?
A
systemic
12
Q
What specific structure does Pemphigoid Gestationis hit?
A
umbilicus
13
Q
Does PUPP hit the umbilcus?
A
no
14
Q
Where does PUPP appear?
A
abdominal striae
15
Q
Is dermatitis herpetiformis itchy?
A
yes
16
Q
Which two areas does dermatitis herpetiformis attack?
A
elbows and knees
17
Q
Which immune cell is involved with dermatitis herpetiformis?
A
neutrophil
18
Q
Which drug can be used to treat DH?
A
dapsone
19
Q
What part of the body does LABD most commonly affect?
A
trunk
20
Q
Does LABD attack the mucus membranes?
A
yes
21
Q
What drug can cause LABD?
A
vancomycin
22
Q
Genes for what disease can predispose to PCT?
A
hemochromatosis
23
Q
Which three non-Genetic factors can cause PCT?
A
ethanol
estrogens
chronic Hep. C
24
Q
What part of the body does PCT most commonly affect?
A
hands
25
Superficial blood vessels with circumferential IgG deposition is indicative of what disease?
PCT
26
What drug can be used to treat PCT?
chloroquine
27
What are two other names for Pseudoporphyria?
drug induced porphyria
bullous dermatosis of dialysis
28
What causes Bullous Diabeticorum?
weakness of basement membrane
29
Which isotypes of desmoglein for PV?
one and three
30
Which two immune proteins deposit during PV?
C3 and IgG
31
Which protein acorrding to Abbott, is cleaved during impetigo and SSSS?
desmoglein-1
32
Where does a friction blister occur?
below stratum corneum
33
What protein is dysfunctional during Hailey-Hailey disease?
calcium pump
34
What two areas does Hailey-Hailey present?
groin and axillae
35
Two treatments for Hailey-Hailey?
tetracyclines and steroids
36
What protein is dysfunctional during Dariers disease?
calcium pump
37
What causes Grovers Disease?
sweating and heat
38
What type of patients does Grovers Disease occur?
bedridden
39
What gene is mutated during Gorlin Disease? What signaling molecule is involved? Chromosome involved?
PTCH
Sonic hedgehog
chromosome nine
40
How does Gorlin Disease present?
multiple BCCs
41
What is a Marjolin's Ulcer?
SCC in a previous burn
42
Which cancer can coarse along nerves?
SCC
43
Which two HPV isotypes are associated with Anogenital Verrucous Carcinoma?
six and eleven
44
What type of -plasia for Actinic Keratosis?
Dysplasia
45
What builds up during Actinic Keratosis?
excessive keratin
46
What is the mode of inheritance for Xeroderma Pigmentosum?
AR
47
What cells give rise to a Merkel Cell Carcinoma?
neural crest
| or neuroectoderm
48
What female tumor can metastisize to the skin?
breast
49
What is another name for Lymphangiosarcoma?
Stewart-Treves
50
Do angiosarcomas have good or poor prognosis?
poor
51
Whats another name for a skin tag?
Fibroepithelial Polyp
52
Which two cysts are full of keratin?
dermoid cyst
Trichilemmal Cyst
53
When does a Dermoid Cyst present?
birth
54
Where does a Dermoid Cyst present?
lateral aspect of eyelid
55
What is the mode of inheritance for Steatocystoma?
autosomal dominant
56
What is a Trichilemmoma called? Associated with what disease?
benign hair follicle tumor
Cowden
57
What gene for Cowden Syndrome?
PTEN
58
Cowdens Syndrome present with malignancies in which two areas?
breast and thyroid
59
Birt-Hoge-Dube presents with tumors in which two organs?
lung and renal
60
What can sebaceous hyperplasia be confused with?
BCC
61
What disease can a Sebaceous Adenoma be associated with?
Muir-Torre Syndrome
62
What syndrome is Muir-Torre Syndrome associated with?
HNPCC
63
Which two diseases are Xanthogranuloma associated with?
CML and neurofibromatosis
64
What is a Xanthogranuloma also called?
Juvenile Xanthoma
65
Which LCH is most aggressive?
Letterer-Siwe
66
What are the three presentations of Hand-Schuler-Christian?
lytic skull lesion
diabetes insipidus
proptosis
67
Which CD molecule is LCH associated with?
CD1a
68
Are Schwannomas encapsulated?
yes
69
Schwannoma has what PROMINENT structure?
blood vessels
70
Are neurofibromas encapsulated?
no
71
What is superficial fibromatosis of the foot called?
Ledderhose Disease
72
What are the two flat lesions?
macule and patch
73
What is the size of a macule?
less than one cm
74
What is the size of a patch?
greater than one cm
75
What are the four raised lesions?
papule
nodule
tumor
plaque
76
What is the size of a papule?
less than one cm
77
What is the size of a nodule?
more than one cm
78
What is the size of a tumor?
greater than 2cm
79
What is flat topped?
plaque
80
What are the two clear fluid containing lesions?
vesicles and bulla
81
What is the size of a vesicle?
less than one cm
82
What is the size of a pustule?
greater than one cm
83
What fluid containing lesion has pus?
pustule
84
What skin disease does M. furfur cause?
Tinea versicolor
85
What rxn does 14-alpha-demethylase catalyze?
lanosterol to ergosterol
86
What enzyme does terbinafine inhibit?
squalene epoxidase
87
What is the number one cause of death in Lupus?
cardiovascular
88
After what age are nevi unlikely to appear?
fifty
89
What cells are implicated in Halo Nevus?
T-lymphocytes
90
What is another name for Benign Juvenile Melanoma?
Spitz Nevus
91
Which nevus is sensitive to catecholamines?
Nevus anemicus
92
What lamp for tuberous sclerosis?
Woods
93
Pityriasis alba is seen in children with what?
atopy
94
What UV is absorbed by window glass?
UVB
95
What makes Polymorphous Light Eruption better?
chronic sun exposure
96
Which lesion is seen during a Salmon patch?
macule
97
What is another name for Mongolian Spots?
Dermal Melanocytosis
98
Which lesion is seen during a Mongolian Spot?
macule
99
Are Mongolian Spots more seen in darker or lighter skinned individuals?
darker
100
Preauricular abnormalities are associated with what?
hearing loss
101
Which disease presents with macules 2-3cm in diameter with a central vesicle or pustule?
Erythema Toxicum Neonatorum
102
What two areas are not affected by Erythema Toxicum Neonatorum?
palms and soles
103
Which disease similar to Erythema Toxicum Neonatorum presents but affects palms and soles?
Transient Neonatal Pustular Melanosis
104
Soap or no soap for acne?
no soap
105
Has resistance develop to Benzoyl Peroxide?
no
106
Can topical antibiotics be used as monotherapy?
no
107
What is the mode of inheritance for Sturge Weber?
sporadic
108
How does Sturge Weber present in the brain?
Meningeal hemangiomas
109
Do Meningeal hemangiomas affect the contralateral or ipsilateral side during Sturge Weber?
ipsilateral
110
How big do Cafe-Au-Lait spots need to be in prepubertal kids?
> 5mm
111
How big do Cafe-Au-Lait spots need to be in postpubertal kids?
> 15mm
112
What two cranial manifestations occur during Tuberous Sclerosis?
hydrocephalus
seizures
113
No sunscreen for babies under what age?
six months
114
What SPF rating for a kid older than six months?
above 15
115
According to Volker, which topical drug can reduce photodamage?
topical tretinoins
116
Seborrheic Dermatitis can present with what other disease?
Parkinsons
117
What is another name for Neurodermatitis?
Lichen Simplex Chronicus
118
What are the three drugs for scabies?
permethrin and malathion or ivermectin
119
Can Actinic Keratosis resolve?
yes
120
What is more common, BCC or SCC?
BCC
121
Can dermatomyositis cause calcinosis?
yes
122
Can sun exposure exacerbate dermatomyositis?
yes
123
According to Oshea, which four drugs can cause cutaneous lupus?
HCTZ
CCBs
ACEIs
terbinafine
124
According to Oshea, what is localized scleroderma called?
Morphea
125
A 'Lilac Ring' is indicative of what disease?
Morphea
126
What are the two presentations of Sweet's Syndrome?
tender, erythematous plaques and macules
neutrophil invasion
127
What disease associated with diabetes can present looking like ringworm?
Granuloma annulare
128
Is Psoriatic Arthritis seronegative or seropositive?
negative
129
What is the mode of inheritance for Peutz Jegher?
autosomal dominant
130
What is the mode of inheritance for Osler-Webb-Rendu?
autosomal dominant
131
Where do exanthems appear?
skin
132
Where do enanthems appear?
mucus membranes
133
Where does the rash of measles begin?
head
134
What is another name for exanthem subitum?
roseola
135
Where does HFM start?
mouth
136
What other dermatological abnormality is Pityriasis Rosea mistaken for?
ringworm
137
What type of wart might shaving cause?
flat
138
What bacteria causes Erythrasma?
Cornyebacterium
139
What type of infection does erythmasma mimmic?
fungal
140
What are the two treatments for Erythmasma?
benzoyl peroxide and erythromycin
141
What is Ecthyma?
ulcerated impetigo
142
Does ecthyma have lymphadenopathy?
no
143
What ointment for impetigo?
mupirocin
144
What structure does a carbuncle extend into?
subQ fat
145
What is an infection of anapocrine sweat gland called?
Hidradenitis suppartiva
146
Does cellulitis have a poor or well defined border?
poor
147
Which bacteria for a human bite?
Eikenella corrodens
148
Does Erysipelas have a poor or well defined border?
well
149
What is another name for Tinea Pedis?
athletes foot
150
What does KOH dissolve?
keratinocytes
151
What is another name for ringworm?
tinea corporis
152
What is another name for jock itch?
tinea cruris
153
What is aother name for scalp ringworm?
tinea capitis
154
What is the drug of choice for Tinea Capitis?
oral griseofulvin
155
What disease does Malassezia furfur cause?
tinea versicolor
156
What causes candidal paronychia?
chronic exposure to water
157
Which bug causes RMSF?
Rickettsia ricketsii
158
What organisms transmits RMSF?
Dermacentor
159
Do adults with Atopic Dermatitis have a rash on their flexur or extensor surfaces?
flexor
160
What percent of kids with AD have more than one symptom of atopy?
50-80%
161
What is Samter's Triad?
aspirin
asthma
atopy
162
What protein links atopy and asthma?
Filaggrin
163
Is the swelling of angioedema in the epidermis or dermis?
dermis
164
Is urticaria in the epidermis or dermis?
epidermis
165
What is a scratch that leads to a wheal in the arm called?
Dermatographism
166
Does urticaria get allergy testing?
no
167
According to Patestas, what layer of the skin do Langerhans Cells reside?
stratum spinosum
168
According to Patestas, what layer of the skin do Merkel Cells reside?
basale
169
According to Patestas, is the number of melanocytes the same for all races?
yes
170
According to Patestas, which layer of skin contains lipid?
stratum granulosum
171
Which embryonic layer does the dermis arise from?
mesoderm
172
According to Patestas, which structure is responsible for the formation of fingerprints?
dermal ridges
173
What type of collagen is found in the dermis ?
three
174
What does LABD stand for?
Linear IgA Bullous Dermatosis
175
A 'Cluster of Jewels' corresponds to what disease?
LABD
176
What two populations is PV more common in?
jewish and mediterranean
177
Does PV have eruptions in multiple stages or the same age?
multiple
178
Does BP arise on normal or erythematous skin?
erythematous
179
Does PV arise on normal or erythematous skin?
normal
180
Is Loss of Staining positive or negative for Muir torre Syndrome?
loss = positive
181
What syndrome are Cylindromas associated with?
Brooke Spiegler
182
'Jigsaw' pattern refers to what growth?
cylindroma
183
What usually happens to a Juvenile Xanthogranuloma?
spontaneously regress
184
Is a plexiform neurofibroma pathogonomic for NF1?
yes
185
Do patients in anaphylaxis have skin lesions?
no
186
Acute urticaria should resolve within how many weeks?
six
187
What enzyme is deficient during Hereditary Angioedema?
C1 Esterase Inhibitor
188
Do patiets with Hereditary Angioedema respond to anaphylaxis treatment?
no
189
According to Benzoni, what is the Tx for stasis dermatitis?
high potentcy steroids
190
According to Benzoni, can venous ulcers be treated with antibiotics?
no
191
Is Hailey-Hailey in a younger or older population?
older
192
Is Darier disease in a younger or older population?
younger
193
What are the two treatments of Grover Disease?
steroids and phototherapy
194
'Pleomorphic' cells on biopsy are indicative of what pathology?
atypical fibroxanthoma
195
Where does a pilomatrixoma arise?
cheek
196
Secondary tumors can arise from which benign skin growth?
Nevus sebaceous
197
What is the only xanthoma with normal serum lipid levels?
Disseminated
198
Ground Glass Histiocytes are indicative of what type of benign skin lesion?
reticulohistiocytoma
199
According to Abbot, are schwannomas associated with NF?
no
200
Which type of Schwannoma is associated with prominent cells?
A
201
Which type of Schwannoma is associated with a myxoid matrix?
B
202
What is an erosion?
loss of epidermis
203
What is an ulcer?
loss of dermis and epidermis
204
Atypical mole syndrome puts one at risk for which disease?
melanoma
205
Is a compound nevus raised?
yes
206
What can arise from a blue nevus?
melanoma
207
What is it called if older people have sun damage and then develop white spots?
Idiopathic Guttate Hypomelanosis
208
What are lentigo called in older patients?
liver spots
209
Which skin condition can a heat source cause?
erythema ab igne
210
Which sex is affected more by Polymorphous Light Exposure?
womens
211
Is Erythema Toxicum Neonatorum need to be followed or benign?
benign
212
Which is present at birth, ETN or Transient Neonatal Pustular Melanosis?
TNPM
213
Which autoimmune skin condition is made better by the sun?
psoriatic arthritis
214
What gene for Muir-Torre?
MSH2
