Dermatology Flashcards
1
Q
What is acquired perforating keratosis (Kyrle disease)? and with what condition is related?
A
- Dome-shaped and umbilicated papules with a central keratotic crust on legs or less often trunk, neck, arms or scalp. Early lesions→pustular. Late lesions→resemble prurigo nodularis (central keratotic scale)
- Chronic renal failure and Diabetes mellitus
2
Q
Two major exposure associations of Squamous cell carcinoma. How do you call an SCC arising from a burn wound?
A
- Ultraviolet sun exposure
- Chronically wounded, scarred, or inflamed skin
- Marjolin Ulcer
*Within skin overlying a focus of osteomyelitis, radiotherapy scars, venous ulcers
3
Q
Describe the clinical presentation and lesions of pityriasis rosea
A
- Viral prodrome: headache, malaise, fever.
- Lesions: First herald patch→erythematous annular lesion, scaly around edge. In 1 week→clusters of small, scaly, erythematous oval lesions on the trunk in “christhmas tree” pattern (back). Mild pruritus.
4
Q
Treatment for papulopustular rosacea
A
- First line: Topical metronidazole, azelaic acid, ivermectin
- Severe or refractory cases: oral tetracyclines (doxycycline, tetracycline)
5
Q
Treatment for Alopecia areata
A
- Mild/moderate hair loss: topical or intralesional corticosteroids
- Extensive hair loss: topical immunotherapy (diphenylcyclopropenone), oral corticosteroids
*Autoimmune disorder involving the hair bulb cells
6
Q
Treatment for local psoriasis
A
- Topical high-potency steroids: fluocinonide, triamcinolone, betamethasone, clobetasol
- Calciprotiene➡vitamin D ointment
- Coal tar preparation
- Pimecrolimus and tacrolimus (alternative to steroids)
7
Q
Treatment for extensive psoriasis
A
- Ultraviolet light
- Anti-TNF: Etanercept, adalimumab, infliximab
- Methotrexate: last resort except for psoriatic arthritis
8
Q
Treatment of Steven-Johnson syndrome and Toxic epidermal necrolysis (TEN)
A
Intravenous immunoglobulins (IVIG)
*Steroids do not benefit or do not help
