Development of nervous system Flashcards

1
Q

What embryonic event takes place during the third week of embryogenesis.

A

Gastrulation- bilaminar becomes trilaminar

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2
Q

Cells of the epiblast that remain in place form the _________-

A

ectoderm

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3
Q

Some of the cells of the epiblast invaginate and form the ____________.

A

primitive streak

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4
Q

some of the cells of the epiblast detach from the epiblast and form the ________

A

mesoderm.

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5
Q

SOme of the cells detach from the epiblast and move deeper and begin replacing hypoblast cells forming _________.

A

endoderm

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6
Q

3 structures involved in development of nervous system

A

Notochord first
Neural tube
Neural crest

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7
Q

The central nervous system develops from the primitive __________.

A

ectoderm

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8
Q

The first step of the neural system development is the formation of the ___________.

A

neural PLATE

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9
Q

Neural plate becomes ____________.

A

Neural groove

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10
Q

Around week 3 the neural groove begins to close to form the neural tube.

A

Neural tube

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11
Q

The ________________ segments of the spinal cord and their corresponding dorsal and ventral roots are formed by secondary neurulation.

A

sacral and coccygeal

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12
Q

The caudal eminence joins the ___________, and its cavity becomes continuous with the neural canal.

A

neural tube

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13
Q

The peripheral nervous system develops from cells of the_________.

A

neural crest

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14
Q

During 4th week the central canal rostrally gives rise to the 3 primary brain vesicles, which are what?

A

prosencephalon (forebrain)
Mesencephalon (midbrain)
Rhombencephalon (hindbrain)

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15
Q

During 5th week the 3 primary brain vesicles divide into _____ secondary brain vesicles.

A

five

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16
Q

The optic cup and nerves bulge from the _________ to form the eye

A

diencephalon

17
Q

Anterior horn motor neurons innervate skeletal muscle and are classified as __________.

A

Somatic efferent (SE)

18
Q

The lateral horn motor neurons project to autonomic ganglia and are classified as ______________.

A

Visceral efferent (VE)

19
Q

________ are paired blocks of paraxial mesoderm

20
Q

Somites separate and form three main tomes? what are they and what do they develop into.

A

Dermatome= skin
Scleratome =vertebrae
Myotome= muscles

21
Q

Within brainstem, where do sensory and motor fibers go?

A

sensory stay dorsolaterally

motor stay ventrallaterally

22
Q

The cerebellum arises from the rostral part of the ___________.

A

Rhombic lip

23
Q

True/False: the cerebral cortex is formed in a sequence called the “inside-out pattern of development.”

24
Q

How do neurons find their targets?

A

They secrete attractant molecules, called trophic factors or signpost molecules.

25
Neuronal growth cones send out small extensions called what?
filipodia
26
The sensory neurons of dorsal root ganglia are derived from ________.
neural crest cells
27
The anterior neuropore fails to close, stops formation of fetus brain formation, death is inevitable.
Anencephaly
28
What is a failure of the back of the skull to close?
``` cranhioshisis not as important below: meningocele- cyst has meninges meningoencepalocele- meninges plus brain meningohydroencephalocele- meninges plus brain and part of ventricular system ```
29
What is myeloschisis, a defect in closure of posterior neuropore. always involves a failure of vertebral arches to close.
Spina bifida
30
True/False: spina bifida is not preventable.
False, preventable!
31
What should you do to prevent spina bifida?
supplement with folic acid, reduces incidence of neural tube defects.
32
What is failure of migration of parasympathetic ganglion cells from the neural crest? Missing plexus of meissner and Auerbach. Leads to severe constipation
Hirschprung disease
33
Failure of the 2 cerebral hemispheres to separate?
Prosencephalization
34
What does a small eye opening, smooth philtrum, and thin upper lip a clue for?
Fetal alcohol syndrome
35
What is the congenital nervous system defects of fetal exposure to common infectious disease?
``` TORCH Toxoplasmosis Other agents Rubella Cytomegalovirus Herpes simplex virus. HIV infection. ```
36
Zika virus has been associated with a striking increase in the number of reported cases of _________ in newborns.
Microcephaly