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Flashcards in Development of the Kidney Deck (22):

What are the 3 stages of kidney development?

  1. pronephros (3-4 weeks)
  2. mesonephros (4weeks-2months)
  3. metanephros (5 weeks-maturity)


The kidneys develop from the _____ _____ within the _____ _____, a tissue that runs laterally and ventrally to the dorsal aorta lengthwise along the coelom of the embryo.

nephrogenic cord, urogenital ridge


The pronephros and mesonephros start as a clump of cells called



The nephrotomes vesiculate and join to form the _____ _____

mesonephric duct


The mesonephric duct grows _____ to join with the developing _____

caudally, cloaca


After the mesonephric duct joins with the cloaca, it is called the _____ duct



While the mesonephric duct is crucial in development of hte kidney, it eventually becomes ____ in males and ____ in females

part of the male reproductive system and degenerates in females


The vesicular tubules of the pronephros ____ by approximately 4 weeks

degenerate and disappear


In lower vertebrates such as many species of fish, the _____ functions for the entire lifetime of the animal as the kidney.



Metanephros typically develops in land-dwelling vertebrates


What is the mullerian duct or paramesonephric duct?

It is a duct that develops from an invagination of the coelom wall that runs along most of the length of the Wolffian body to also join with the cloaca. This duct is the duct from which the oviducts and uterus develop in females. This duct degenerates in males


The metanephros begins as a tiny bud of epithelial cells from a portion of the mesonephric duct where it joins with the _____. This bud is called the _____ bud

Cloaca, ureteric


The ureteric bud is enveloped by a small region of cells called the _____ _____.

Metanephric blastema


During development, the ureteric bud will grow lengthwise and branches will develop within the tissue of the _____ _____ to initially form the ____ and the regions of the renal pelvis and major and minor calyces.

metanephric blastema, ureter


What are malpighian pyramids?

The regions of developing epithelia from the ureteric bud that will eventually line the calyces generate a series of epithelial-lined out-growths as tubules that run roughly parallel to each other from the medulla into the cortical regions of the kidney. These tubules are called malpighian pyramids.


The ureteric bud branches during kidney development in several stages to give rise to what?


Renal pelvis


Collecting ducts

Collecting tubules


The epithelia of the malpighian pyramids become the ____ _____. They branch and give rise to short branching tubules that become the ____ _____.

collecting ducts, collecting tubules


What is the metanephric spheroid?

It is a cluster of metanephric mesodermal cells that is at the tips of the collecting tubules (originating from the metanephric blastema)


The metanephric spheroids vesiculate to form a _____ _____.

Metanephric vesicle


What is the metanephric tubule?

The metanephric vesicle elongates and forms a short tubule which folds in on itself in the shape of the letter "S". This is the metanephric tubule which eventually forms the rest of the epithelium of the nephron


When does the blood supply of the kidneys develop?

During the development and elaboration of the tissues derived from the ureteric bud, the renal artery and vein begins to supply the developing metanephric blastema. These branch in between the malpighian pyramids as the intralobar vessels, giving rise to the arcuates, interlobular vessels, the glomerular capillaries, efferent arterioles, and vasa recta.


What is the urogenital sinus?

The cloaca is where the hindgut and developing mesonephric duct and allantois all join. When the hindgut leaves the cloaca, the two separate structures are now the urogenital sinus and the rectum.


The kidney proper develops from the _____ _____

ureteric bud