Development Of The Reproductive System Flashcards

1
Q

Which part of the mesoderm does the mesonephric duct derive from?

A

Intermediate mesoderm

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2
Q

What does the coelomic epithelium give rise to in the reproductive system

A

Somatic support cell and mullerian duct derivatives

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3
Q

What does the endoderm give rise to in the reproductive system?

A

Caudal vagina, pelvic and penile urethra, accessory glands e.g. Prostate

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4
Q

Where do the primordial germ cells come from?

A

The yolk sac

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5
Q

When do the germ cells arrive at the primitive gonads?

A

5 weeks

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6
Q

When do the germ cells populate th genital ridges?

A

6 weeks

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7
Q

What do the genital ridges form from?

A

The coelomic epithelium

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8
Q

When do the gonads acquire male or female morphological characteristics?

A

7th week

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9
Q

What is the name of the pluripotent tumour counting for 3% of childhood malignancies?

A

Sacrococcygeal teratoma

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10
Q

Which 2 genital ducts are present in both males and females?

A

Mesonephric duct and müllerian ducts

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11
Q

What are the somatic support cells in the ovary called?

A

Follicular cells

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12
Q

What are the surrounding interstitial cells in the ovary called?

A

Thecal cells

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13
Q

What happens to the primitive sex cords in
A) females
B) males

A

A) they dissociate

B) they continue to proliferate

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14
Q

What are the somatic support cells in the testix called?

A

Sertoli cells

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15
Q

What are the interstitial cells of the testis called?

A

Leydig cells

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16
Q

When do the ducts regress?

A

Weeks 8-10

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17
Q

In females, what do the müllerian ducts form?

A

Fallopian tubes, uterus, upper vagina

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18
Q

In females, what are the remnants of the mesonephric ducts and tubules?

A

Epoöphoron, paroöpharon, gartners cysts

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19
Q

Which ducts fuse to form the uterus?

A

The müllerian ducts

20
Q

What is the cause of a double uterus?

A

Müllerian ducts have failed to fuse

21
Q

What is the broad ligament of the uterus formed from?

A

Peritoneal membrane

22
Q

Where do the sinovaginal bulbs form?

A

Where the müllerian ducts contact the urogenital sinus

23
Q

What do the sinovaginal bulbs form?

A

The vaginal plate

24
Q

In males, what do the mesonephric ducts and tubules form?

A

Epididymis, vas deferens, seminal vesicle, efferent ductales

25
In males, what do the müllerian ducts form?
Appendix testis and prostatic utricle
26
If hox 11 was mutated in males, what would happen?
Vas deferens would be transformed into epididymal-like structure
27
Which condition is congenital bilateral aphasia of the vas deferens associated with?
Cystic fibrosis
28
When are the accessory glands formed in the male?
Weeks 10-12
29
Which cord do the ovaries and testes descend on?
The gubernaculum
30
When do the testes arrive in the scrotum?
Around the time of birth
31
What is the name of the condition in which the testes don't descend properly?
Cryptorchidism
32
What is pseudohermaphrodism?
Discordance between sex chromosomes and secondary sex characteristics
33
How is the penile urethra formed?
Fusion of urethral folds
34
When is fusion of the urethral folds complete?
Week 14
35
What is the condition in which the urethral folds don't fuse completely?
Hypospadias
36
How is the clitoris formed?
Genital tubercles elongate
37
What is the labia majora formed from?
Genital swellings
38
What is the male sex determining gene?
Sry
39
What is the sry target gene?
Sox9
40
Name 3 functions of the pre-sertoli and sertoli cells?
1. Transoently express sry 2. Procure anti-müllerian hormone 3. Recruit mesonephric mesenchymal cells which differentiate into Leydig cells
41
What are the functions of the Leydig cells?
Produce testosterone (and fetal Leydig cells produce dihydrotestosterone)
42
What does dihydrotestosterone do?
Stimulates external male development and testicular descent
43
What does testosterone do?
Stimulates mesonephric duct differentiation
44
What is persistent müllerian duct syndrome caused by?
AMH and AMH receptor mutations
45
What is primary hypogonadism?
Failure of gonad to respond to gonadotropins
46
What is secondary hypogonadism
Failure of hypothalamus and anterior pituitary to produce gonadotropins