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PATH II > developmental and odontogenic cysts day 3 > Flashcards

developmental and odontogenic cysts day 3 Flashcards

1
Q

Orthokeratinizing Odontogenic Cyst
relation to OKC?
occurence?

A
  • A developmental odontogenic cyst with an orthokeratin lining, NOT parakeratin
  • Originally described as the “orthokeratinized variant of the odontogenic keratocyst”
  • Does not behave as an odontogenic keratocyst
  • no recurrence
  • not related to OKC
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2
Q

orthokeratinizing odontogenic cyst radio

A

well defined uniloc lucency

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3
Q

Orthokeratinizing Odontogenic Cyst histo

A

orthokeratin in lumen

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4
Q

Calcifying Odontogenic Cyst
(Gorlin Cyst)
* WHO classified as
* additional names
* location/demo
* radio
* key cell
* Sometimes associated with?

A
  • WHO: Calcifying Cystic Odontogenic Tumor
  • Gorlin cyst, calcifying and keratinizing odontogenic cyst
  • Anterior jaws of adults
  • Radiolucent to mixed
  • Ghost cells
  • Sometimes associated with odontomas
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5
Q

Calcifying Odontogenic Cyst
(Gorlin Cyst) locations

A
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6
Q
A

orthokeratinizing odontogenic cyst

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7
Q

dif dx?

A

Calcifying Odontogenic Cyst (Gorlin Cyst)
Ca epithelial odontogenic tumor
AOT
odontogenic fibroma

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8
Q

dif dx?

A

ca odontogenic cyst
ca epithelial odontogenic tumor
ameloblastic fibro-odontoma

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9
Q

Calcifying Odontogenic Cyst
(Gorlin Cyst) histo

A

possess non-nucleated epi cells= ghost cells

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10
Q
A

ghost cells= Calcifying Odontogenic Cyst
(Gorlin Cyst)

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11
Q
A

Calcifying Odontogenic Cyst
(Gorlin Cyst)
note: ghost cells and calcification present

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12
Q

Glandular Odontogenic Cyst
* defined
* locations, demo
* radio
* behavior / recurrence

A
  • Sialodontogenic cyst –an odontogenic cyst with glandular
    (salivary) features
  • Anterior jaws of middle-aged adults, mandible > maxilla
  • Commonly multilocular, crosses midline
  • Aggressive behavior - 30% recurrence
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13
Q

glandular odontogenic cyst radio

A

well defined multilocular radiolucency

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14
Q

Glandular Odontogenic Cyst histo

A

normal cyst histo with pseudoglandular spaces and cilia on epithelium with goblet cells present

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15
Q

biopsy from anterior maxilla of 50 y/o female, presented as a multilocular lucency crossing the midline

A

glandular odontogenic cyst

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16
Q

Biopsy from the anterior mandible of a 45y/o male presented as a multilocular lucency crossing the midline

A

glandular odontogenic cyst

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17
Q

SOFT TISSUE CYSTS

A

Nasolabial Cyst
Lymphoepithelial Cyst
Cervical Lymphoepithelial Cyst
Thyroglossal Duct Cyst

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18
Q

Nasolabial Cyst
* additional names
* location
* from
* demo

A
  • Nasoalveolar cyst, Klestadt cyst
  • Soft tissue cyst of upper lip lateral to midline
  • Developmental cyst, remnants of nasolacrimal duct
  • Adult females (3:1)
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19
Q

Nasolabial Cyst histo

A

cilia on epithleium with mucus cells present

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20
Q

NL cyst radio

A

none

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21
Q

Oral Lymphoepithelial Cyst
demo?
locations?

A
  • Cystic change of crypt epithelium of lymphoid aggregate
  • Young adults
  • Waldeyer’sring
  • Tonsillar pillar
  • Floor of mouth
  • Ventral tongue
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22
Q

oral lymphoepithelial cyst histo

A

lumen surrounded with epi and large conn tissue wall containing germinal centers or lymphoid aggregates

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23
Q

Cervical Lymphoepithelial Cyst

A
  • Branchial Cleft Cyst
  • Cystic change of branchial epithelium
  • Upper lateral neck anterior to border of sternocleidomastoid muscle in young adults
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24
Q

DST with cervical lymphoepithelial cysts

A

may occur with infection

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25
Q

Cervical Lymphoepithelial Cyst histo

A
  • Stratified squamous epithelial lining exhibiting lymphoid tissue with or without germinal centers in wall
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26
Q

cervical lymphoepithelial cyst radio

A

none

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27
Q

Thyroglossal Duct Cyst

A
  • Cystic change of thyroglossal tract epithelium
  • Midline of neck in young people
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28
Q

thyroglossal duct cyst histo

A

follicles in conn tissue wall

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29
Q
A

thyroglossal duct cyst

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30
Q

PSUEDOCYSTS

A

Lack epithelial lining
Traumatic Bone Cyst
Aneurysmal Bone Cyst
Static Bone Cyst

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31
Q

Traumatic Bone Cyst additonal names

A
  • Idiopathic bone cavity
  • Solitary bone cyst
  • Hemorrhagic bone cyst
  • Simple bone cyst
  • Unicameral bone cyst
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32
Q

Traumatic Bone Cyst
structure?
theory of origin?

A
  • Empty cavity - not a true cyst, pesudocyst
  • Trauma-hemorrhage theory of origin
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33
Q

Traumatic Bone Cyst
*demo
* location
* radio
* outline
* symptomatic
* Expansion
* teeth
* Biopsy

A
  • Male (2:1)
  • Teenagers –young adults
  • Mandible
  • Lucency
  • Scalloped border frequent
  • Asymptomatic
  • Expansion rare (20%)
  • Vital teeth
  • Biopsy initiates healing, little tissue and cells maybe bone fragments
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34
Q
A

traumatic bone cyst radio

35
Q

Aneurysmal Bone Cyst
*demo
* growth, symptoms
* location
*radio

A
  • Young individuals < 20 years
  • Rapidly growing, may blow out the cortex, painful
  • Mandible most commonly
  • Lucency, frequently multilocular
36
Q
A

Aneurysmal Bone Cyst

37
Q

how else could a aneurysmal bone cyst look on radio

A

unilocular

38
Q

Surgical Findings Aneurysmal Bone Cyst
*bone
* blood
* gross appearence
* pigmentation

A
  • Ballooning dilation of bone
  • Blood welling up from within the cavity, like a blood-soaked sponge
  • Fleshy aggregates of tumor surrounding cystic spaces filled with blood
  • Hemosiderin pigmentation
39
Q

Aneurysmal Bone Cyst histo

A
  • Not a true cyst
  • Cyst-like cavities, filled with blood (lots of RBC)
  • Multinucleated giant cells
40
Q

biopsy, from a multilocular luceny in mandible

A

Aneurysmal Bone Cyst

41
Q

biopsy, from a multilocular luceny in mandible

A

Aneurysmal Bone Cyst

42
Q

Static Bone Cyst (Stafne Defect)
* symptoms
* Radio
*etiology

A
  • Asymptomatic
  • Radiolucency below inferior alveolar nerve canal
  • portion of Submandibular gland stuck in bone with man development
43
Q

Static Bone Cyst (Stafne Defect) histo

A

resembles subman gland=mixed, mainly serous

44
Q

Classes of ODONTOGENIC TUMORS

A

Epithelial
Mesenchymal
Mixed

45
Q

epithelial odontogenic tumors

A
  • Ameloblastoma
  • Adenomatoid Odontogenic Tumor
  • Calcifying Epithelial Odontogenic Tumor
46
Q
  • Mesenchymal derived odontogenic tumors
A
  • Odontogenic myxoma
  • Odontogenic fibroma
  • Cementoblastoma
    *
47
Q

mixed odontogenic tumors

A
  • Odontoma
  • Ameloblastic Fibroma
  • Ameloblastic Fibro-odontoma
48
Q

Spectrum of Odontogenic Tumors

A
49
Q

Ameloblastoma radio app

A

can be multi or unilocular, mainly uniloc

50
Q

Ameloblastoma
defined?
demo?
location?
recurrence?
histo resembles what structure?
does not form what tissue?

A
  • An expansive, slow-growing, locally invasive lesion, typically of the posterior mandible of adults (mean = 35 y)
  • Recurrence is common but does not metastasize *
  • The histopathology of ameloblastoma recapitulates the enamel organ
  • Ameloblastoma does not form and hard tissue
51
Q

ameloblastoma locations

A
52
Q

dif dx

A

ameloblastoma
OKC
aneurysmal bone cyst

53
Q

Histologic Types Ameloblastoma

A
  • Solid: Follicular, Plexiform, Desmoplastic, Many more………
  • Unicystic
54
Q

The histopathology of ameloblastoma
does not form?

A

The histopathology of ameloblastoma recapitulates the
enamel organ
* Ameloblastoma does not form and hard tissue

55
Q

histo of ameloblastoma (high power)

A

odontogenic epithelium with basal cells possessing reverse polarity surrounding stellate reticululm

56
Q

Follicular Ameloblastoma histo

A

same but with follicles containig the distinct ameloblastoma histo

57
Q

Plexiform Ameloblastoma

A

similar to follicular but follicles form anastomoses

58
Q

Desmoplastic Ameloblastoma
* Location
* density

A
  • Anterior jaws, equally distributed between mandible and maxilla
  • Mottled mixed density with diffuse margins
  • Solid tumor with dense, collagenous stroma
59
Q

desmoplastic ameloblastoma radio

A

can be mixed or opaque, dense fibrous conn tissue creates the opacity

60
Q

what could this opacity be?

A

desmoplastic ameloblastoma

61
Q

what type of ameloblastoma is this?

A

desmoplastic, dense fibrous conn tissue with compression of the odontogeic islands

62
Q

peripheral vs central ameloblastomas

A

can arise in the jaw or at its periphery

63
Q

Unicystic Ameloblastoma
radio?
location?
demo age?
recurrence?

A
  • Cystogenic ameloblastoma
  • Unilocular pericoronal radiolucency, usually of posterior mandible –mimics a dentigerous cyst radiographically
  • 2nd to 3rd decades (Mean age = 18 y)
  • Recurrence uncommon
64
Q

dif dx

A

unicystic ameloblastoma
OKC
dentigerous cyst

65
Q

Unicystic Ameloblastoma(Vickers-Gorlin Change) histo

A
  • Nuclear hyperchromatism
  • Nuclear palasading
  • Reverse polarity of basal cell nuclei
  • Subnuclear vacuolation
66
Q
A

unicystic ameloblastoma, note the loose epithelium palasaded basal cells and reverse polarity of basal cells

67
Q
  • Sialodontogenic cyst –an odontogenic cyst with glandular
    (salivary) features
  • Anterior jaws of middle-aged adults, mandible > maxilla
  • Commonly multilocular, crosses midline
  • Aggressive behavior - 30% recurrence
A

Glandular Odontogenic Cyst
* defined
* locations, demo
* radio
* behavior / recurrence

68
Q

normal cyst histo with pseudoglandular spaces and cilia on epithelium with goblet cells present

A

Glandular Odontogenic Cyst histo

69
Q

cilia on epithleium with mucus cells present

A

Nasolabial Cyst histo

70
Q
  • Cystic change of crypt epithelium of lymphoid aggregate
  • Young adults
  • Waldeyer’sring
  • Tonsillar pillar
  • Floor of mouth
  • Ventral tongue
A

Oral Lymphoepithelial Cyst
demo?
locations?

71
Q

lumen surrounded with epi and large conn tissue wall containing germinal centers or lymphoid aggregates

A

oral lymphoepithelial cyst histo

72
Q
  • Branchial Cleft Cyst
  • Cystic change of branchial epithelium
  • Upper lateral neck anterior to border of sternocleidomastoid muscle in young adults
A

Cervical Lymphoepithelial Cyst

73
Q
  • Stratified squamous epithelial lining exhibiting lymphoid tissue with or without germinal centers in wall
    from region anterior to SCM mm
A

Cervical Lymphoepithelial Cyst histo

74
Q
  • Empty cavity - not a true cyst
  • Trauma-hemorrhage theory of origin
A

Traumatic Bone Cyst
structure?
theory of origin?

75
Q
  • Male (2:1)
  • Teenagers –young adults
  • Mandible
  • Lucency
  • Scalloped border frequent
  • Asymptomatic
  • Expansion rare (20%)
  • Vital teeth
  • Biopsy initiates healing, little tissue and cells maybe bone fragments
A

Traumatic Bone Cyst
*demo
* location
* radio
* outline
* symptomatic
* Expansion
* teeth
* Biopsy

76
Q
  • Young individuals < 20 years
  • Rapidly growing, may blow out the cortex, painful
  • Mandible most commonly
  • Lucency, frequently multilocular
A

Aneurysmal Bone Cyst
*demo
* growth, symptoms
* location
*radio

77
Q
  • Not a true cyst
  • Cyst-like cavities, filled with blood (lots of RBC)
  • Multinucleated giant cells
A

Aneurysmal Bone Cyst histo

78
Q
  • Asymptomatic
  • Radiolucency below inferior alveolar nerve canal
  • portion of Submandibular gland stuck in bone with man development
A

Static Bone Cyst (Stafne Defect)
* symptoms
* Radio
*etiology

79
Q

resembles subman gland=mixed, mainly serous

A

Static Bone Cyst (Stafne Defect) histo

80
Q
  • An expansive, slow-growing, locally invasive lesion, typically of the posterior mandible of adults (mean = 35 y)
  • Recurrence is common but does not metastasize *
  • The histopathology resembles the enamel organ
  • does not form and hard tissue
A

Ameloblastoma

81
Q

odontogenic epithelium with basal cells possessing reverse polarity surrounding stellate reticululm

A

histo of ameloblastoma

82
Q
  • Anterior jaws, equally distributed between mandible and maxilla
  • Mottled mixed density with diffuse margins
  • Solid tumor with dense, collagenous stroma
A

Desmoplastic Ameloblastoma
* Location
* density

83
Q
  • Unilocular pericoronal radiolucency, usually of posterior mandible –mimics a dentigerous cyst radiographically
  • 2nd to 3rd decades (Mean age = 18 y)
  • Recurrence uncommon
A

Unicystic Ameloblastoma

84
Q
  • Nuclear hyperchromatism
  • Nuclear palasading
  • Reverse polarity of basal cell nuclei
  • Subnuclear vacuolation
A

Unicystic Ameloblastoma(Vickers-Gorlin Change) histo

PATH II (24 decks)

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