Diabetes 1 Flashcards
(39 cards)
Diabetes mellitus
A chronic disease related abnormal insulin production( disprder of the pancreas)
Impaired insulin utilisation
Characterized hy hyperglycemia
Normal glucose level
4-7.8 mmol/l (diabetes aus)
3.9- 6.1 mmol/l ( brown)
Regulation of blood glucose level
Pancreas
Liver
Pancreas
A digestive and endocrine gland
Endocrine function: Secretes glucose, insulin , somatostatin
Liver
Glucose metaolism Glycogen storage Glycogenesis Glycogenolysis Regualtion of blood glusoce concentration
Normal insulin metabolism
Only hormone that directly lowers bgl Produced by b cells in islet of langerhan Promotes glucose transport across cell memebranes Stimulates glycogenesis, glycogenolysis Increase protoen synthesis
Glycogenesis
Storage of glucose as glycogen
Hormones that opsoe the effects of insulin
Glucagon , epinephrine, growth hormone, cortisol
Stimulate glucose production by liver
Decrease movement of glucose
Type 1 diabetes
No insulin being produced
Type 2 diabetes
Person is resistant to the insulin being produced
Diabetes aetiology
Person eats/drinks-
Blood glucose rises
Vete cells in pancreas detect rise in blood glucose
Pancreas releases insulin into the blood
( 1 : no insulin 2: resistant to insulin)
Tissue cells take up glucose
Blood glucose falls
Diabetes 1 risk factor
Not inherited, but genetic predisposition combined with immunologic and possibly environmental factor
Type 2 diabetes risk factor
Family history Race Pbese Poor nutrition Smoking High bp
Clinical manifestation of high bgl
3 ps
Polyuria: urine
Polydipsia: excessive thrist
Polyphagia : excessive hunger
Other symptoms of high bgl
Weight loss Weakness Blurred vision Headache Numbness of feet Wounds slow to heal Recurrent infection
Classifications of diabetes
Type 1 Type 2 Gestational Pre diabetes Secondary diabetes
Type 1 diabetes
Insulin producing b cells in pancreas destroyed by autoimmune process
No insulin production
Wffects of lack of glucose in insulin production
Catabolism Adipogenesis Glycogenesis Result - poor utilisation of glucose lead to feeling of hunger, tiredness, increased breakdown of alternate engery sources
Catabolism
Impeded due to the lack of transport of glucose into the cytoplasm
Adipogenesis
Glucose conversion into fattty acid is limited due to the lack of insulin
Glycogenesis
Glucose is stored in liver and muscle as glycogen. This is activated by insulin l, therefore limited
Treatment of type 1 diabetes
Insulin injections
Type 2 diabetes
Pancreas continues to produce insulin by insufficient or poorly utilised by body
Pathophysiology of type 2 diabetes
Insulin resistance
Decreased insulin production
Increased glucose production
Altered production of hormones and cytokines bu adipose tissue