Diabetes Drugs

Question 1

Give an example of a biguanide

Answer 1

metformin

Question 2

MOA of metformin

Answer 2

Increases insulin sensitivity and decreases liver production of glucose

Question 3

Side effects of metformin

Answer 3

Diarrhoea and abdo pain
Lactic acidosis
NO HYPOS

Question 4

Give an example of a thiazolidinediones

Answer 4

Pioglitazone

Question 5

MOA of pioglitazone

Answer 5

Increases insulin sensitivity and decreases liver production of glucose

Question 6

side effects of pioglitazone

Answer 6

Weight gain 
Fluid retention 
Anaemia 
HF and risk of bladder Ca
NO HYPOS typically 
not for use in HF

Question 7

give an example of a DPP4 inhibitor

Answer 7

sitagliptin

Question 8

give an example of a sulfonylurea

Answer 8

gliclazide

Question 9

SE of gliclazide

Answer 9

Weight gain
HYPOS
Increased risk of CVD and MI if used monotherapy.

Question 10

MOA of gliclazide

Answer 10

stimulates insulin release from the pancreas

Question 11

MOA of sitagliptin

Answer 11

Stops the inhibition of the action of GLP-1 so increases insulin secretion and decreases glucagon production.

Question 12

side effects of sitagliptin

Answer 12

GI tract upset
URTI
Pancreatitis

Question 13

Give an example of a GLP-1 mimetic

Answer 13

exenatide

Question 14

example of SGLT2 inhibitor

Answer 14

dapagliflozin

Question 15

MOA of exenatide

Answer 15

mimic action of GLP1

Question 16

MOA of SGLT2 inhibitor

Answer 16

SGLT-2 protein reabsorbs gluvose in kindey at PCTso by inhibiting, glucose is lost in urine.

Question 17

SE of exenatide

Answer 17

GI tract upset
Weight loss 
Dizziness
Low risk of hypo	
good for BMI>35

Question 18

SE of dapagliflozin

Answer 18

Glucoseuria
Increased rate of UTI
Weight loss
Diabetic Ketoacidosis