Diabetes meds Flashcards Preview

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Flashcards in Diabetes meds Deck (9)
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1

Amylin mimetic

Released with insulin (assists w/postprandial glucose control)

ex. pramlintide

2

Glucagon-like Peptide 1 (GLP-1) receptor agonist

Mimics incretins

DECREASE
-Gastric emptying
-Appetite

INCREASE
-Release of insulin


Side effects:
N/V/D
Hypoglycemia
Headache


Med names end in "glutide"

3

Dipeptidyl peptitdase-4 inhibitors

Work with incretins

Stim insulin release from beta cells

Decrease glucagon production in liver


Side effects: Pancreatitis, allergic reactions

end in liptin

4

What are incretins?

Hormones that stimulate decrease in blood glucose

5

SGLT-2 inhibitors

decrease glucose by increasing its excretion in urine

Side effects:
UTI
Genital infections
Hypoglycemia


med names end in "liflozin"

6

Biguanide

Decrease glucose production in liver

Make tissue respond to insulin


Side effects:
-Giving IV contrast fluids (for CT etc.) can cause renal failure. Lactic Acidosis (both are excreted by kidneys) caused by metformin accumulating in kidneys and not filtering.

ex. metformin

7

Thiazolidinediones (TZD)

Inc. glucose uptake in muscles

Dec. endogenous glucose production

side effects:
Weight gain

Pioglitazone: May inc risk bladder cancer, worsen HF

Rosiglitazone: May inc. risk for CV event

Med names end in "litazone"

8

Alpha-glucosidase inhibitors

Delay carbohydrate digestion and absorption

Stops glucose rising post meal

9

Sulfonylureas

Stimulates insulin release from pancreas

Inc. cellular insulin sensitivity

Decrease glyconeogenesis and glycogenolysis

Side effects:
Weight gain, hypoglycemia

Treat type 2

end in "ide"