Disease causation and the diagnostic process in relation to public health, prevention and health promotion. Flashcards

1
Q

Issues that complicate early years intervention evaluation

A
  • Study designs: Ethics of RCTs on preventative interventions, evaluating national interventions such as fortification of flour to improve pregnancy outcomes.
  • Lack of control group/ poorly designed studies over time
  • Difficult to measure absence: impossible to project over 20 years what disease prevalence/crime rates might be, how to show the absence of that?
  • Lead times: Early years has long term follow up, studies are costly and complex to F/U over this time frame. E.G childhood education to reduce smoking and lifetime risk of lunch ca.
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2
Q

Five key areas of early years evidence

A

Eduction, Nutrition, Socio-economic benefits, Emotional and social supply, Combined programmes.

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3
Q

Education programmes in early years

A

Pre school education and parenting education.
Pre school:
Sylvia et al 2004. Cohort study, 3000 children across Europe.
Pre school attenders had higher educational and social attainment.
Quality of schooling did affect attainment
Socioeconomic status did not affect benefit gained by preschool
What parents did with children had more affect than SE status, e.g reading.

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4
Q

Health and nutrition in early years

A

LBW- increases risk of chronic conditions. Evidence suggests maternal nutrition affected weight, Ca and folate supplements have shown positive outcomes. (Healthy start scheme) Smoking doubles risk of LBW.
Breastfeeding- increased passive immunity, lower SIDs, Reduced obesity, diabetes and atopy, greater bonding, reduced risk of breast and ov cancer in mothers.
Childhood immunisations
Interventions to reduce injuries e.g cycle helmets.

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5
Q

East Sussex childhood injuries picture

A
  • ES 67% of admission due to accidents in under 5s happened within a home.
  • High rates in ES compared to England. Particularly bad in deprived areas of Hastings and Rother.
  • Higher rates of falls, and accidental poisonings.
  • East Sussex fire and rescue service offers home visits for safety checks, education and fitting of safety equipment
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6
Q

Socio- economic benefits in early years

A

Acheson Report
Families with young children are at increased risk of poverty:
Need affordable childcare
Increase benefits and availability of benefits for pregnant women and families with young children.

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7
Q

Emotional/social support in early years

A

Evidence for community family support programmes.
Aim to improve parent wellbeing, and children physical, emotional and cognitive development.

European Early Promotion project (2005) found healthcare worker training to support parent infant relationships led to fewer psychological problems in children.

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8
Q

Combined programmes in early years

A

Programmes that combine multiple aspects.
Sure start (UK)/ Head start (USA)

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9
Q

Pre determinants of health

A

Factors that indicate/contribute to determinants of health.
Material: Food and water, clean air, Income, housing, Green spaces.
Policy: Minimum wage, Occupational health, Maternal services, Childcare, Benefits and education.
Society: Social cohesion, values and attitudes, ethnic diversity and tolerance, language ability.

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10
Q

Social cohesion

A

Pre determinant of health.
Society with strong social cohesion- strong interactions, supportive, few inequalities.

Wilkinson (1996) reduced income differentials, greater solidarity, and social cohesion lead to improvements in life expectancy.

Can influence and be influenced by health policy. E.g private insurance could increase inequality.

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11
Q

Motivational interviewing

A

Motivational interviewing: Rollnick and Miller (1990s) counselling based on the stages of change model. Explores models about why an individual may be ambivalent about behaviour change.

Evidence in drug misuse, smoking cessation, eating disorders.

It utilities: empathy, highlight discrepancies, roll with resistance (respond with understanding not confrontation), build self efficacy.

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12
Q

Individual behaviour change techniques

A

Motivational interviewing, CBT, incentives

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13
Q

Incentives

A

Marteau et al 2009
vouchers to encourage smoking cessation, points scheme for healthy school meals (UK)
money towards healthcare costs in improve adherence (USA)
Financial rewards to avoid STIs (Tanzania)
Financial rewards for achieving weight loss targets (Italy)

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14
Q

Incentives- pros and cons

A

+ effective in short term
+ potential effective long term combines with other activities
- Moral concerns- bribery
- overall paternalistic
poor use of public funds

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15
Q

Define social marketing

A

Use of techniques of commercial marketing ti sell a health message

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16
Q

Approach to social marketing

A
  • Identify target group: segmentation tactics (define group by lifestyle choice rather than disease state)
  • Research target group: survey and focus groups. Assess attitudes, habits, needs.
  • Competitive analysis: competition is anything that may encourage the unhealthy behaviour e.g tobacco marketing
  • Set objectives
  • Develop a message: pretest with target group
  • Sell the message
  • Evaluate
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17
Q

Four Ps of marketing

A

Product : It must be clear what is being sold.
Price: financial na opportunity costs
Place: channel used affects exposure to certain groups
Promotion: medial and advertising, e.g TV, Magazine, partnership with companies.

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18
Q

Strengths and weakness of social marketing

A

+ Based on understanding of the target group
+ Clear objectives
+ Uses successful commercial techniques

  • Assumes behaviour is individual choice
  • Danger of portraying partial message e.g “Just say no” catchier than well rounded pos/neg of drugs
  • Can reinforce same stereotypes as commercial marketing e.g health = positive physical attributes or = positive moral attributes
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19
Q

Reasons for public involvement

A
  • Improved concordance
  • Empowerment
  • Democracy
  • Acceptability
  • Ownership and sustainability
  • Integrated approaches: More complex issues are tackled with community members insights as a problem solving tool.
  • Better decisions
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20
Q

Absolute vs relative poverty

A

Absolute: Lacks basic material needs
Relative: lives under 60% of median national income

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21
Q

Factors that reinforce the effects of deprivation

A

Social exclusion, discrimination, employment, stress, antenatal effects.

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22
Q

Local strategic partnerships

A

Statutory multi agency bodies

Functioned in areas of LA

Encourage collaborative working and community involvement

Statutory, voluntary, community and private sectors

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23
Q

Why do we set targets in healthcare?

A

Adaptation of management practices and culture
Improvement of performance and accountability
Consistency

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24
Q

Levels of target setting

A

Individual e.g personal PDP

Organisational e.g LA target for provision of affordable housing

National e.g Public Service Agreement- Given set minimum target for sectors in return offer investment, schools/health etc

International: WHO’s SDGs, Health for All targets

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25
Q

Criteria for good targets

A

Specific
Measurable
Achievable
Relevant
Timely

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26
Q

Pros and Cons of targets

A

+ Provide a focus for performance improvement
+ Explicit priority setting - provides common agenda for a team.
+ Provide accountability
+ Level playing field for organisations under comparison
+ Targets reflect organisations priorities and goals
+ Share good practice
+ Increase interest in particular areas

  • Might not be measurable (particularly in health), such may take focus away from some health areas
  • Gaming (distortions of practice). e.g reclassifying trolleys in ED as beds to meet 4h targets.
  • Distort priorities. Areas where targets are not easily set may be neglected
  • Disengagement from staff when targets set top down.
  • Costs
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27
Q

Things to consider when setting targets

A

Closely correlate to clinical outcomes
Select with consensus from team- evidenced, feasibly, acceptable
multiple time frames

Consider which priorities we want the public to know are important/ form of education public on important targets

Targets are practical expression of guidelines

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28
Q

Donabedian’s Framework

A

(2005)
Framework to evaluate health programmes.

Structure/input, process and outcome measures/targets applied to each to evaluate programmes.

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29
Q

Programming approach

A

Epidemiological paradigm
Long term effects of environmental exposures during critical periods.

E.g Barker Hypothesis- in utero malnutrition as a risk factor for CHD

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30
Q

Adult risk factor approach

A

Epidemiological paradigm
Impact of lifestyle and behaviours

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31
Q

Life course approach

A

Epidemiological paradigm
Combines elements if programming and adult risk factor approach.

Various risk factors across gestation and life affect health and disease.

Limitation:
Little research on very longitudinal cohorts.

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32
Q

Screening: Definition

A

Aim: Identify people who can be helped in the early stage of disease.

“identify apparently healthy people in the early stages of disease/increased risk. Such that they can be offered information, or further tests and treatment.”

NSC: National Screening Committee

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33
Q

UK Screening programmes

A

Antenatal:
Early- HIV, Syphilis, hepatitis B, Rubella, Haemolytic diseases, Sickle cell, thalassaemia.
Mid- Downs, Fatal abnormalities.

Neonatal:
Heel prick- PKU, Congenital hypothyroid, sickle cell and thalassaemia, CF, MCADD
Hearing screening
Heart defect, cataract, Malformations, cryptorchidism, hip dislocation.

Childhood:
Growth- turners, growth hormone deficiency
Hearing
Vision

Adult:
AAA- one off USS at 65.
Breast ca- 3 yearly mammogram 50-71
Cervical ca - HPV test, 25-49, 3 yearly
Bowel ca- Feacal occult blood, 60-69, 2 yearly.
DM retinopathy- 12 year + with DM, annually.

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34
Q

Non screening secondary prevention programmes

A

Health checks
Childhood obesity
Chlamydia
Prostate ca
TB

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35
Q

Reasons for setting high sensitivity for screening tests

A

Significant disease with definitive treatment
Rick of infectivity to others
Subsequent test cheap/low risk

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36
Q

Reasons for setting high specificity for screening tests

A

Unpalatable treatment
Costly/ high risk subsequent test

37
Q

ROC curves

A

Receiver operated characteristic curves

Plots the trade off between sensitivity and specificity (TP/FP)
- Aids threshold setting for tests
- Helps compare different possible screening tests

Should be high and left

38
Q

Active case finding

A

Systematically searching for high risk people. E.g GP identification of high risk CHD, Genetic testing of family, case finding in disease outbreaks.

+ Cheap
+ Low personal demand
+ Improves PPV of a test
+ Targets prevention
+ Cost effective for familial conditions

  • Potential to widen inequalities for hard to reach groups
39
Q

Likelihood ratios

A

How many more times people with the disease are likely to have a positive test result

LR > 1 test result is associated with presence of disease. > 10 high likelihood

LR < 1 Result indicates absence of disease

The further from one indicates stronger association.

Positive LR = Sensitivity/ (1- specificity)

40
Q

Pre test probability

A

“the probability of the screened person having the disease”

= prevalence

Pre test odds = Pre-test probability/ [1 – Pre-test probability]

Using routine data, practice data, and clinical judgement

41
Q

Post test probability

A

“is the probability of the patient having a disease after obtaining the test results”

Can be extrapolated from PPV - but this is based on prevalence

Can also be estimated from pre test probability and LR - (using Bayesian statistics)
Fagans nomogram can be used.

42
Q

Factors that affect screening participation

A

+ Perception of severity
+ Perception of susceptibility
+ Perception of benefit
+ Knowledge of disease
+ Knowledge of treatment

  • Phobia
  • Disease severity (low)
  • High residential mobility
  • Low acceptance of test
  • Stigma
  • Inaccessibility
43
Q

Informed choice in screening

A

GMC
Patients need to know

  • Purpose of the test
  • Risks of test
  • Likelihood of positive findings
  • Possibility of false results
  • Implications of screening
  • Follow up
44
Q

Screening : Evaluation

A
  1. Relative burden of disease
  2. Feasibility
    Organising attendance, acceptability, post screen care, costs
  3. Effectiveness
    - Extent to which the programme affects outcomes
    - Consider bias (selection, lead time, length time)
    - Issues with understanding over diagnosis, takes time/ long follow up.
45
Q

Screening : Planning

A

Consider:
Who is eligible
How often to screen
Invitations
Quality assurance

Wilson and Jungner criteria-
Disease is :
Important, pre clinical stage/natural history known. latent period.
Test is:
Valid, simple/cheap, acceptable, reliable
Follow up:
Agreed policy in place, facilities to diagnose/treat, Treatment available
Overall:
Evidenced, Acceptable, Opportunity cost balanced, adequate staffing/facilities, Clear management, patient able to make an informed choice.

46
Q

Screening : Case study’s (bowel, breast, prostate)

A

Bowel ca- England uptake 69.6% 21/22
Less in deprived areas compared to affluent areas.

Breast ca- DH and Ca research review found that for 10 000 screen cases 43 deaths prevented, 129 over diagnosed. Suggested new information should be given to reflect this.

Prostate ca- Not recommended. Test low sens/spec, unclear which treatment option is the best.

Cervical cancer
England uptake- 69%

47
Q

Control of genetic disease

A

testing of embryos
Ante/neonatal testing
Screening for genetic conditions
Treatment to reduce risk (familial hypercholesterialaemia)
Genetic counselling

48
Q

National nutrition surveillance

A

Food supply data- imports/exports, agricultural data, food mapping exercises.

ONS Living cost and food survey- annual, self reported diaries, 5,000 homes across the UK.

Diet and nutrition surveys- (Self reported, biased and unreliable ) DH and food standards agency: National diet and nutrition survey. 1000 adults.

Breast feeding survey, every 5 years
School meals - from LA catering services.
Self reported surveys- children,

49
Q

Nutritional interventions

A

Flouridation of water
Fortification of food- folic acid in flour.
School and workplace campaign- canteen meals
TV
Collaboration with food industry
Free fruit in schools
Sugar tax

50
Q

Social determinants of diet

A

Poverty
Ethnicity/culture
- BAME- Higher fruit and veg, less fat, higher salt intake
Education

51
Q

Dietary reference values

A

Used by professionals
Values set by healthy people in different age brackets
Estimated average requirement
Reference nutrient intake - amount needed by 97%
Lower reference nutrient intake - amount needed by 2.5%
Safe intake

52
Q

Challenges in evidence for nutrition

A

Hard to obtain undisputed evidence
Ensuring risks are accepted
Implementing evidence to change consumption
Long term outcomes of CHD hard to research
Ethical issues of RCTs

Seven countries study- shows a link between animal fats and CHD, compared to med diets

53
Q

Environmental determinants of health

A

Global warming/climate change
Sustainable development
Housing
Built environment
Transport
occupation
Water and sanitation
Agriculture and food
Air quality
Temperature, noise, radiation
Chemical agents
Biological agents

54
Q

Environmental injustice

A

Exposure to environmental risk factors is greater amount more deprived people, but wealthier people are responsible for more pollution.

E.g
Weather people won care- pollute- affects people living in urban areas/poor housing

global carbon dioxide is produced by weather countries but effects of climate change felt most in developing areas

55
Q

Environmental risk vs hazard

A

Hazard- potential to harm health (pollution, radiation, extreme temps)

Risk- probability of an unfavourable event occurring x consequences of that event

56
Q

Effects of climate change on health

A

Direct:
Heatwaves, extreme weather

Indirect:
Changing epi of IDs
Floods- water borne disease, changing vectors
Resp diseases & pollution
Droughts- food insecurity
Rising sea levels- displacement
reduced farming activity
Pressure on resources - war
Increased skin cancer

57
Q

Responding to climate change

A

Mitigation- reduce greenhouse gasses

Adaptation- flood defences, increased vaccine programmes, sun protection advice

58
Q

Define and principles of sustainable development

A

Definition: “meeting our needs today without compromising the ability of those to meet their needs tomorrow”

Respecting the environment, resources, biodiversity

Health and justice- meeting needs of all communities

Governance

Evidence based - precautionary principle

Sustainable economy - Polluter pays principle

59
Q

Water pollutants

A

Fertilisers - nitrates, phosphates
Metals- Aluminium, lead, Heavy metals
Slurry- organic waste
Sewage

60
Q

Radiation

A

Ionising - 84% produced by naturally occurring radon gas, need to improve ventilation in homes where this occurs (due to geology). 15% healthcare <1% due to industry. Acute radiation sickness, or long term exposure e.g cancer

Non ionising- sun/ power lines/ phones. cancer, cataracts, sunburn.

Measured - Gray (GY) Energy deposited in each gram of tissue.
Single exposure of 5Gy across body- fatal

61
Q

Principle air pollutants

A

CO
Ozone
Nitrogen dioxide (cars)/ sulphur dioxide (coal) - resp illness, acid rain
Lead-
Particulates- car emissions, resp and Cv disease
Organic compounds- traffic emissions, industrial processes- carcinogenic, smog
Radon

62
Q

2 principles of EU environment legislation

A

Polluter pays:
Party responsible for creating pollution pays for recovery/clean up/ recycling/ disposal. Or tax on business that use non friendly products/processes

Precautionary principle:
Credible but unproved hazards should be treated as real threats. err on side of caution.

63
Q

Compliance with environmental legislation

A

Business not aware of legislation
Monitoring variable across EU
Penalties weak
compliance not previewed as key to business survival

64
Q

UK agencies involved in occupational health

A

Health and safety executive
Trade unions
LA
Employers
occupational health

65
Q

Collectivism

A

That the state has a responsibility for the population.

Drink driving laws
Health and safety regulation
Fluoridation of water
Tax

66
Q

Individualism

A

Political/moral philosophy that emphasises the individual.

Safe drinking limits advertised
Alcohol licences to allow purchase 24H a day
private healthcare providers

67
Q

Policy Rainbow

A

Dahlgren and Whitehead 1991

Determinants exist and interconnected layers. Age, sex non modifiable but others are modifiable, and interact with health in different ways.

Used in London Health Commission report

68
Q

Health Belief model

A

Hochbaum 1958

Person will take health related action if:
Perceived susceptible
Perceived severity
Course of action available
Benefits outweigh risks
Perceived ability to carry out action

+Useful for simple preventative behaviours
+ Evidenced to predict behaviour/improve interventions

  • Complex long term behaviours (alcohol dependance) doesn’t work as well
  • Doesn’t account for factors outside personal beliefs, e.g culture, provision of healthcare.
69
Q

Stages of change model

A

Prochaska and DiClemente 1984

Behaviour change as a process. Predicts who will change behaviour and who will fail to progress through.

Pre contemplation, contemplation, determination, action, maintenance, termination.

+ Useful for complex long term behaviour changes
+ Can tailor counselling to the stages the patient is at
+ useful for programme planning to plan interventions sequentially

  • Less useful for whole communities.
70
Q

Spheres of health promotion

A

Tannahil 1985

Three overlapping spheres of activity- health education, protection against harm, prevention of disease.

+ simple
+ Widely adopted
+ encompasses wellbeing

  • Difference between prevention and protection is arbitrary
71
Q

Beattie Model

A

1991
Considers activities for health promotion and how they are delivered. Useful tool for critically evaluation of promotion programmes.

2 axis- authoritative- negotiated, individual - collective.

4 approaches - health persuasion, Personal counselling, Legislative action, Community development.

72
Q

Health messages

A

McGuire

Source - ?credibility/trust
Message
Channel - medium and setting
Receiver - primed? targeted
destination- outcome of message

73
Q

Requirements for successful communication

A

Be seen/heard by target
Attract attention
Be understood
Be accepted
Change behaviour

74
Q

Mass communication

A

+simple
+many recipients
+ Useful for reinforcing ideas
+ same message reaches all

  • Low flexibility
  • No feedback
  • Don’t know its been seen/heard
  • Expensive
75
Q

Individualised communication

A

+ Can challenge current attitudes
+ Complex messages
+ Can also use counselling techniques (support self efficacy)
+ flexible
+ feedback

  • Small numbers
  • Variability in dissemination of message
76
Q

Community development: Activities

A

Formal participation, community action (priority setting), Facilitation (by health service), Interface (work closely with community), Strategy (support)

77
Q

Community development: +/-

A

+ Projects are based in community proprieties
+ Focus on root cause of ill health
+ positive process of involvement, confidence, control
+ Can reach excluded groups

  • Resource intensive
  • time consuming
  • hard to secure funding
  • Long timescale
  • results often intangible
  • Conflict of accountability for community workers
78
Q

Partnership working

A

Types: within organisation, across local areas, outreach to community

Methods: Statutory committee, Shared targets, Joint projects, Specific initiatives, joint post, shared budget

+ avoids duplication
+ Pools resources
+ Political imperatives

  • Shared outcomes?
  • different processes
  • requires commitment
  • power dynamic
  • influence
79
Q

Surveillance

A

Detects trends, Evaluate prevention/control measures, alert for threats, monitor known IDs, research

Passive, active, enhances, sentinel, syndromic.

Evaluation:
Importance of condition under surveillance
Clear case definition?
System/process - objectives, process
Analysis- methods
Usefulness
Recommendations for improvement

80
Q

Evaluation of vaccine programmes

A

Disease surveillance
Sero-epidemiological surveillance
Market testing
Monitor adverse events

81
Q

Developing and immunisation strategy: General considerations

A

Mass vs selective
Live vs attenuated
Age
Dose interval
Outbreak response
Surveillance
Containment
Investment in research

82
Q

Developing and immunisation strategy: Mass vs selective

A

Mass- herd immunity. E.g Rubella

Selective - high risk groups, less costly, less adverse events e.g hep B

83
Q

Outbreak investigation: concurrent tasks

A

Epidemiology
Control measures
Collect environmental samples
Outbreak control group
Communication

84
Q

Outbreak investigation:

A

Epidemiology
Case definition
Confirm cases
Define background rate
Assess if outbreak has occurred

Active case finding
Time/place/ person characteristics
Epi curve
Generate hypothesis

Test hypothesis
Conclude

85
Q

Outbreak investigation: Control measures

A

Control source, spread.
Protect at risk persons
Continue surveillance

Declare outbreak over when back to background levels
Consider future control

86
Q

Outbreak investigation: outbreak control group

A

HP cons
Micro/ viro/toxo
Admin
Food/vets
Epidemiologist
DPH
GP

Other involved orgs - Environmental health, food standards, water standards etc

87
Q

WHO disaster management cycle

A

Prevention
Preparedness
Detection and alert
Response
Recovery

88
Q

Routine micro techniques

A

Microscopy, culture, id, drug sense testing

+low cost
+ definitive diagnosis

  • Take time
  • Low sensitivity
  • can’t always isolate organism
  • may not be able to provide strain with limited techniques
89
Q

Reference lab techniques

A

Nucleic acid probes/ amplification systems

+ Incase sens/spec
+ ID orgs that don’t grow on culture
+ Genes that result in resistance
+ Epi tracking
+ New infections
+ Control of Abx resistance

  • Specialist equipment
  • Some techniques have longer turnaround times