Disease/Important associations Flashcards
(134 cards)
1
Q
Actinic (solar) keratosis
A
Precursor to suamous cell carcinoma
2
Q
Acute gastric ulcer associated with CNS injury
A
Cushing ulcer ( increase intracranial pressure stimulates vagal gastric secretion
3
Q
Acute gastric ulcer associated with severe burns
A
Curling ulcer (greatly reduced plasma volume results in sloughing of gastric mucosa)
4
Q
Alternating areas of transmural inflammation and normal colon
A
Skip lesions ( Chrohn disease)
5
Q
Aneurysm, dissecting
A
Hypertension
6
Q
Aortic aneurysm, abdominal and descending aorta
A
Atherosclerosis
7
Q
Aortic aneurysm, arch
A
tertiary syphilis (syphilitic aortitis) vasa vasorum destruction
8
Q
Aortic aneurysm, ascending
A
Marfan syndrome ( idiopathic cystic medial degeneration)
9
Q
Atrophy of the mammillary bodies
A
Wernicke encephalopathy (thiamine deficiency causing ataxia, opthalmoplegia and confusion_
10
Q
Autosplenectomy (fibrosis and shrinkage)
A
Sickle cell anemia (hemoglobin S)
11
Q
Bacteria associated with gastritis, peptic ulcer disease, and stomach cancer
A
H. Pylori
12
Q
Bacterial meningitis (adults and elderly)
A
Streptococcus pneumoniae
13
Q
Bacterial meningitis ( newborns and kids)
A
Group B streptococcus/E.Coli (newborns), S.pneumoniae? Neisseria meningitidis (kids)
14
Q
Benign Melanocytic nevus
A
Spitz nevus ( most common in 1st two decades)
15
Q
Bleeding disorder with DpIb deficiency
A
Bernard-Soulier syndrome ( defect in platelet adhesion to von willebrand factor)
16
Q
Brain tumor (adults)
A
Supratentorial: metastasis greater than astrocytoma ( including glioblastoma multiforme) greater than meningioma greater than schwannoma
17
Q
Brain tumor (kids)
A
Infratentorial: medulloblastoma (cerebellum) or supratentorial : crainiopharyngioma
18
Q
Breast cancer
A
Infiltrating ductal carcinoma
19
Q
Breast mass
A
Fibrocystic change, carcinoma ( in postmenopausal women)
20
Q
Breast tumor (benign)
A
Fibroadenoma
21
Q
Cardiac 1 tumor (kids)
A
Rhabdomyoma, often seen in tuberous sclerosis
22
Q
Cardiac manifestation of lupus
A
Libman-Sacks endocarditis ( nonbacterial, affecting both sides of mitral valve)
23
Q
Cardiac tumor (adults)
A
Metastasis, primary myxoma ( 4:1 left to right atrium; “ball and valve”)
24
Q
Cerebellar tonsillar herniation
A
Chiari II malformation
25
Chronic arrhythmia
Atrial fibrillation ( associated with high risk of emboli)
26
Chronic atrophic gastritis (autoimmune)
Predisposition to gastric carcinoma (can also cause pernicious anemia)
27
Clear cell adenocarcinoma of the vagina
DES exposure in utero
28
Compression fracture
Osteoporosis ( type I: postmenopausal women; type II: elderly man or woman)
29
Congenital adrenal hyperplasia, hypotension
21-hydroxylase deficiency
30
Congenital cardiac anomaly
VSD
31
Congenital conjuagted hyperbilirubinemia (black liver)
Dubin-Johnson syndrome (inability of hepatocytes to secrete conjugated bilirubin into bile)
32
Constrictive pericarditis
TB (developing world) ; SLE (developed world)
33
Coronary artery involved in thrombosis
LAD greater than RCA greater than LCA
34
Cretinism
Iodine deficit/hypothyroidsim
35
Cushing syndrome
- Iatrogenic Cushing (from corticosteroid therapy)
- Adrenocortical adenoma (secretes excess cortisol)
- ACTH-secreting pituitary adenoma
- Paraneoplastic Cushing (due to ACTH secretion by tumors)
36
Cyanosis ( early; less common)
Tetralogy of Fallot, transposition of great vessels, truncus arteriosus
37
Cyanosis ( late; more common)
VSD, ASD, PDA
38
Death in CML
Blast crisis
39
Death in SLE
Lupus nephropathy
40
Dementia
Alzheimer disease, multiple infarcts
41
Demyelinating disease in young women
Multiple sclerosis
42
DIC
severe sepsis, obstetric complications, cancer, burns, trauma, major surgery
43
Dietary deficit
Iron
44
Diverticulum in pharynx
Zenker diverticulum ( diagnosed by barium swallow)
45
Ejection click
Aortic/pulmonic stenosis
46
Esophageal cancer
squamous cell carcinoma (worldwide); adenocarcinoma (U.S)
47
Food poisoning (exotoxin mediated)
S. aureus, B. cereus
48
Glomerulonephritis (adults)
Berger disease (IgA nephropathy)
49
Gynecologic maliganancy
Endometrial carcinoma ( most common in U.S); cervical carcinoma ( most common worldwide)
50
Heart murmur, congenital
Mitral valve prolapse
51
Heart valve in bacterial endocarditis
Mitral greater than aortic ( rheumatic fever, tricuspid ( IV drug abuse)
52
Helminth infection ( U.S.)
Enterobius vermiculars, Ascaris lumbrioides
53
Hematoma-epidural
Rupture of middle meningeal artery ( trauma; lentiform shaped)
54
Hematoma- subdural
Rupture of bridging veins ( crescent shaped_
55
Hemochromatosis
Multiple blood transfusion or hereditart HFE mutation ( can result in CHF, "bronze diabetes" and increase risk of hepatocellular carcinoma)
56
Hepatocellular carcinoma
Cirrhotic liver (associated with hep B and C and with alcholism)
57
Hereditary bleeding disorder
von Willebrand disease
58
Hereditary harmless jaundice
Gilbert syndrome ( benign congenital unconjugated hyperbilirubinemia)
59
HLA-B27
Ankylosing spondylitis, reactive arthritis, ulcerative c olitis, psoriatic arthritis
60
HLA-DR3 or DR4
Diabetes mellitus type 1, rheumatoid arthritis, SLE
61
Holosystolic murmur
VSD, tricuspid regurgitation, mitral regugitation
62
Hypercoagulability, endothelial damage, blood statis
Virchow triad ( results in venous thrombosis)
63
Hypertension, 2ndary
Renal disease
64
Hypoparathyoidism
Accidental excision during thyroid dectomy
65
Hypopituitarism
Pituitary adenoma (usually benign tumor)
66
Infection 2 to blood transfusion
Hep C
67
Infections in chronic granulomatous disease
Staph aureus, E. Coli, Aspergillus ( catalase +)
68
Intellectual disability
Down syndrome, fragile X syndrome
69
Kidney stones
Calcium = radiopaque
Struviate (ammonium)_radiopaque ( formed by urease + organism such as proteus vulgaris or staph
Uric acid - radiolucent
70
Late cyanotic shunt (uncorrect left to right becomes right to left)
Eisenmenger syndrom ( cause by ASD, CSD, PDA; results in pulmonary hypertension/polycythemia)
71
Liver disease
Alcholic cirrhosis
72
Lysosomal storage disease
Gaucher disease
73
Male cancer
Prostatic carcinoma
74
Malignancy associated with noninfectious fever
Hodgkin lymphoma
75
Malignancy (kids)
ALL, medulloblastoma (cerebellum)
76
Metastases to bone
Prostate,breast greater than lung greater than thyroid
77
Metastases to brain
Lung greater than breast greater that geniturinary greater than melanoma greater than GI
78
Metastases to liver
Collon way greater than stomach, pancreas
79
Mitochondrial inheritance
Disease occurs in both males and females, inherited through females only
80
Mitral valve stenosis
Rheumatic heart disease
81
Mixed (UMN and LMN) motor neuron disease
Amyotrophic lateral sclerosis
82
Myocarditis
Coxsackie B
83
Nephrotic syndrome (adults)
Focal segmental glomerulosclerosis
84
Nephrotic syndrome (kids)
Minimal change disease
85
Neuron migration failure
Kallmann syndrome (hypogonadotropic hypogonadism and anosmia)
86
Nosocomial pneumonia
Klebsiella, E.coli, pseudomonas aeurginosa
87
Obstruction of male urinary tract
BPH
88
Opening snap
Mitral stenosis
89
Opportunistic infection in AIDS
Pneumocystis jirovecii pneumonia
90
Osteomyelitis
S. Aureus
91
Osteomyelitis in sickle cell disease
Salmonella
92
Osteomyelitis with IV drug use
Pseudomonas, S. Aureus
93
Ovarian metastasis from gastric carcinoma or breast cancer
Krukenberg tumor (mucin-secreting signet-ring cells)
94
Ovarian tumor (benign, bilateral)
Serous cystadenoma
95
Ovarian tumor (malignant)
Serous cystadenomcarcinoma
96
Pancreatitis (acute)
Gallsones, alcohol
97
Pancreatitis (chronic)
Alcohol (adults), cystic fibrosis (kids)
98
Patients with ALL/CLL/AML/CML
ALL: child, CLL: Adult > 60, AML: adult - 65, CML: adult 30-60
99
Pelvic inflammatory disease
Chlamydia trachomatis, Neisseria gonorrhoeae
100
Philadelphia chromosome t (9:22) (bcr-abl)
CML ( may sometimes be associated with ALL.AML)
101
Pituitary tumor
Prolactinoma, somatotropic "acidophilic"adenoma
102
primary amenorrhea
Turner syndrome (45 XO)
103
primary bone tumor (adults)
Multople myeloma
104
primary hyperaldosteronism
Adenoma of adrenal cortex
105
primary hyperparathyroidism
Adenomas, Hyperplasia, carcinoma
106
primary liver cancer
Hepatocellular carcinoma ( chronic hepatitis, cirrhosis, hemochromatosis, a1-antitrypsin deficiency)
107
Pulmonary hypertension
COPD
108
Recurrent inflammation.thrombosis of small//medium vessels in extremities
Beurger disease (strongly associated with tobacco)
109
Renal tumor
Renal cell carcinoma:associated with von hippel-lindau and cigarette smoke; paraneoplastic syndromes (EPO, renin, PTH, ACTH)
110
Right heart failure due to pulmonary cause
Cor pulmonale
111
S3 (protodiastolic gallop
Increased ventricular filling ( left to right shunt, mitral regurgiation, LV failure (CHF)
112
S4 (presystolic gallop)
Stiff/hypertrophic ventricle (aortic stenosis, restrictive cardiomyopathy)
113
2ndary hyperparathyroidism
Hypocalcemia of chronic kidney disease
114
Sexually transmitted disease
Chylamydia (usually coinfected with gonorrhea)
115
SIADH
Small cell carcinoma of the lung
116
Site of diverticula
Sigmoid colon
117
Sites of atherosclerois
Abdominal aorta> coronary artery > popliteal artery > carotid artery
118
Stomach cancer
Adenocarcinoma
119
Stomach ulcerations and high gastrin levels
Zollinger-Ellison syndrome (gastrinoma of duodenum or pancrease)
120
t(14;18)
Follicular lymphomas (bcl-2 actvation)
121
t(8;14)
Burkitt lymphoma (c-myc activation)
122
t(9;22)
Philadelphia chromosome, CML (bcr-abl fusion)
123
Temporal arteritis
Risk of ipsilateral blindness due to thrombosis of opthalmic artery; polymyalgia rheumatica
124
Testicular tumor
Seminoma (malignant, radiosensitive)
125
Thyroid cancer
Papillary carcinoma
126
Tumor in women
Leiomyoma (estrogen dependent, not precancerous)
127
Tumor of infancy
Hemangioma (usually regresses spontaneously by childhood)
128
Tumor of adrenal medulla (adults)
Pheochromocytoma (usually benign)
129
Tumor of the adrenal medulla (kids)
Neuroblastoma (malignant)
130
Type of Hodgkin
Nodular sclerosis (vs. Mixed cellularity, lymphocytic predominancy, lymphocytic depletion)
131
type of non-hodgkin
Diffuse large cell
132
UTI
E. coli, Staph saprophyticus (young women)
133
Viral encephalitis affecting temporal lobe
HSV-1
134
Vitamin deficiency (U.S)
Folate (pregnant women are at high risk; body store only 3 to 4 month supply; prevents neural tube defects)
