Diseases of prostate Flashcards Preview

Unit 1 ID+LC > Diseases of prostate > Flashcards

Flashcards in Diseases of prostate Deck (10):
1

Most common effect on prostate due to aging

atrophy
*but not really a condition

2

Prostatic diseases
- causes
- signs

1. Inflammation
2. Hyperplasia
3. Neoplasia

Nl asymptomatic until advanced

Symptoms when present are usually those of urethral obstruction or irritation

3

causes of Acute prostatitis

1. Enterobacter (E. coli)
S. aureus
2. Direct extension from urinary tract
3. Iatrogenic (hospital)

4

Benigns prostatic hyperplasia (BPH)

most common proliferative disease of the prostate

- benign nodular enlargement of prostate

Blacks>whites> Asians

More common the older you get

Lower urinary tract symptoms most common
- quality of life impact

5

Complications of BPH

1. Acute urinary retention
2. Recurrent UTI/pyelonephritis
3. Renal failure
4. Incontinence

*mainstay tx is medical

6

Most common non-skin cancer of adult males

prostatic carcinoma
(1 in 5 , 20% of all male cancers)

- second leading cause of male cancer deaths (behind lung)

7

Prostatic cancer risk factors

Age
Race (black, then white)
Genetics

*and a shit ton of others

8

Prostatic carcinoma affects which zones more?
Gold std for diagnosis?
Are these usually solitary or multifocal?

Peripheral zone > transition zone

Blind "random" biopsies
- can miss tumor due to heterogeneity of tumor

Multifocal
- tumor can very quickly arise as high grade lesion
- need to treat low grade tumor

9

Prostatic intraepithelial neoplasia

noninvasive precursor to some prostate cancers (30-50%)
- genetic and molecular changes similar to PCa

10

Gleason grading

Grading for Prostatic adenocarcinoma
- stage correlates with morphology
- higher stage = higher mortality
- lack of glandular epithelium is hallmark of pathology