Disorders of Ca and PT gland Flashcards Preview

Endocrinology > Disorders of Ca and PT gland > Flashcards

Flashcards in Disorders of Ca and PT gland Deck (20):
1

Where are CaSR found?

PT, kidney, C cells, bone

2

Causes for hypercalcemia

#MISHAP (malignancy, intox of VD, sarcoidosis, hyperpara, alkali, pagets

Also Familial hypocalciuric hypercalcemia or meds induced (lithium or HCTZ)

3

Etiology of primary hyperparathyroidism

80-85% adenoma
15% hyperplasia (MEN1, MEN2A)
<1% carcinoma

4

Epidemiology of hyperparathyroidism

women, AA>W>H

5

Pt with hypercalcemia have what symptoms?#

stones, bones, groans psychiatric overtones

6

What happens to hyperparathyroid in post-kidney transplant or end-stage renal disease

Glands become hyperplastic and autonomous

7

What will PTH be in hypercalcemia due to malignancy and granulomatous disease?

Suppressed

8

Initial treatment of acute hypercalcemia

address volume status. Calcitonin, bisphosphonates, GC,

9

What are the major causes of secondary PTH elevation?

Hypocalcemia, hyperphosphatemia, VD deficiency

10

What happens to VD in renal disease?

decrease 1a hydroxylase- decreased active VD

11

____% of pt with osteoporosis have VD deficiency

50

12

Clinical signs of hypocalcemia

trousseaus, chvosteks, hyperreflexia, agitation, convulsions, hypertension, long QT

13

What are causes of primary hypoparathyroidism?

post-thyroidectomy, idiopathic, autoimmune, agenesis (DiGeroge), hypomagnesaemia, hypermag, hyperphosph

14

Miscellaneous causes of hypocalcemia

acute pancreatitis, massive transfusion, tumor lysis, severe sepsis, meds, hungry bone syndrome

15

What is the clinical manifestation of pseudohypoparathyroidism?

elevated PTH, hypocalcemia, hyperphosphatemia, short stature, round face, knuckle knuckle dimple dimple (esp 4th), obesity, Albright's hereditary osteodystrophy

16

What is the molecular defect for pseudohypoparathyroidism?

inability of PTH to stimulated intracellular events

17

Should we memorize pseudohypoparathyroidism classifications?

Nah.

18

Tx of acute hypocalcemic crisis?

correct mg. Calcium gluconate

19

Timeline of MEN1 phenotype

Hypercalcemia by age 40. Pituitary tumors between 12 and 38. Insulinomas at 25. Gastrinoma at 35

20

Crazy looking tongue is a clinical feature of ____.

MEN2B (mucosal neuromas)