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Pathology I Test II > Disorders of the immune system > Flashcards

Flashcards in Disorders of the immune system Deck (246)
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1

Immunity is from a latin term that means what?

Exemption from duty.

2

What are the 2 types of immune responses?

1. Natural immunity (non-specific). 2. Acquired immunity (Specific).

3

What are the 3 proteins that work under the natural immunity response?

1. Complement. 2. Properdin. 3. Lysozyme.

4

What is the general concept of acquired immunity?

Self vs. non-self.

5

What is the 1st, 2nd, and 3rd lines of defense in natural protection?

1. Mechanical/ chemical barrier. 2. inflammatory/ Phagocytosis. 3. Specific immune responses.

6

What are the different kinds of T-Lymphocytes?

T-helper cells (CD4+), T-suppressor or cytotoxic cells (CD8+), and Natural killer cells.

7

B-lymphocytes will become what in tissues?

Plasma cells.

8

Where will T and B lymphocytes and Natural killer cells come from?

Bone marrow.

9

Basophils become what in tissues?

Mast cells.

10

Monocytes become what in tissues?

Macrophages.

11

All antibodies are composed of what?

Light and heavy chains.

12

Which chains of antibodies are changeable and which chain is the same?

Light- same. Heavy are specific for each Ig.

13

What is another name for light and heavy chains?

Light-Fc. Heavy-Fab.

14

What is the largest Ig?

IgM.

15

What is the function of the IgM?

To neutralize microorganisms.

16

The IgM has how many complement binding sites?

five.

17

What is the first Ig to appear?

IgM.

18

IgM is the natural antibody against what?

ABO blood group ag.

19

Which Ig has the smallest molecular weight?

IgG.

20

When will IgG be produced?

Small amounts produced on initial immunization and boosted on re-exposure.

21

IgG's act as an opsonin which is what?

bacteria coating and phagocytosis.

22

IgA will be mainly found where?

In mucosal secretions; milk, tears, respiratory, GI tract.

23

What is the function of IgA?

Protective.

24

What Ig is secreted by sensitized plasma cells in tissues?

IgE.

25

IgE are attached locally to what?

Mast cells.

26

What is the function of IgE's?

mediates allergic reactions in tissues, and to protect against parasites.

27

Where are IgD's found at?

Cell membrane-bound found exclusively on B cells.

28

What is the function of the IgD?

participates in antigenic activation of B cells

29

Which of the Ig's will not be released in the serum?

IgD.

30

What is the Major Histocompatiblity complex essential for?

presentation of antigens to T cells.