Distribution

Question 0

Peripheral

Answer 0

Vessel-poor

Muscle, skin, fat

Question 1

Central

Answer 1

Plasma & vessel-rich
Liver, brain, kidneys, heart
IV medications distribute via this path
Action for Sedatives and narcotics

Question 2

Cardiac output w/vessel-rich

Answer 2

75%CO

Question 3

CO w/muscle

Answer 3

19% CO

Question 4

CO w/fat

Answer 4

6% CO

Question 5

CO w/vessel poor

Answer 5

0.5% CO

Question 6

Factors affecting distribution

Answer 6

Protein binding decreases available drug
Protein availability affects bound and free fraction of drug
Lipid solubility
Ionization

Question 7

Albumin binds

Answer 7

Basic drugs(barbiturates)

Question 8

A1AG bind

Answer 8

Acidic drugs (local anesthetics)

Question 9

Decreased albumin availability causes

Answer 9

Liver, kidney, CHF, CA

Question 10

Increased A1AG

Answer 10

trauma, infection, MI, chronic pain

Question 11

Volume of distribution

Answer 11

Quantifies the distribution of a medication between plasma and the rest of the body after dosing

Volume in which the amount of drug would need to be uniformly distributed to produce the observed blood concentration

Question 12

Initial volume of distribution

Answer 12

Distribution of a drug throughout the body after dosing and prior to reaching a steady state Equilibrium

Question 13

VD

Answer 13

Total amount of drug in the body
_____________________________
Drug blood concentration

0.7 total body water