Propofol Flashcards
(27 cards)
Protein binding
95-99%
Mechanism of action
Interaction with GABA
Delays association of GABA from receptors
Increasing GABA activated opening of Cl channel
Acts as a Na channel blocker
Hyper polarization of cell membranes
Elimination half life
30-60 mins
Metabolized
Glucoronidation in the liver
Clearance exceeds hepatic blood flow
30% may occur in lungs
Excretion
Renal
Therapeutic window
Plasma concentration 1.5-2 mcg/ml
Cardiovascular effects
Decrease systolic BP, SVR, HR
arterial and venous vasodilation decrease preload and afterload
Pulmonary effects
RR depressed dose dependent
Apnea after bolus
Reduces airway reflexes
CNS effects
decreased cerebral blood flow, ICP, CMRO2, IOP
Caution with decrease systolic and cerebral blood flow
Decreased CPP
Supplied at
10 mg/ml
Older adult doses
Reduce dose
Children dose induction
2.5-3.5 mg/kg
Onset of unconsciousness
30-60/ seconds
Sedation dose
25-100 mcg/kg/min
Anesthesia dose (TIVA)
100-300 mcg/kg/min
Is propofol an analgesic?
NO
Bacteria
Bacteria forms in the bottle and in the syringe and can keep up to 6 hours
Propofol infusion syndrome
Acute refractory bradycardia (kids) -RBBB early sign -asystole Metabolic acidosis Rhabdomyolisis Hyperlipidemia Enlarged fatty liver >4mg/kg longer than 48 hrs
Awaken why
Redistribution
Greater CV depression than
NaP
Similar respiratory effects as NaP except
Good bronchodilator
Does NOT cause
Hyper analgesia
What happens with N/V
Reduces PONV & PDNV
