Diuretics

Question 1

Drugs that induce a state of increased urine flow are ____

Answer 1

diuretics

Question 2

Major methods to increase urine flow:

Answer 2

o Decrease reabsorption of Na+
o Prevent water reabsorption
o Antagonize aldosterone

Question 3

In many conditions/diseases NaCl reabsorption is abnormally high which leads to:

Answer 3

o Retention of water
o Increase in BP
o Expansion of the extravascular fluid compartment

Question 4

Carbonic Anhydrase Inhibitors

work mainly in ______

Answer 4

proximal convoluted tubule

Question 5

Acetazolamide (Diamox) is what type of diuretic?

Answer 5

Carbonic Anhydrase Inhibitors

Question 6

Acetazolamide (Diamox) therapeutic uses

Answer 6

o Mild diuretic
o Glaucoma – most common use
o Altitude/mountain sickness

Question 7

Acetazolamide (Diamox) ADRs

Answer 7

o	Mild metabolic acidosis
o	Hypokalemia
o	Renal stones
o	Drowsiness
o	Paresthesia
o	These are rare with treating eye 
Usually systemic causes ADRs

Question 8

name 4 loop diuretics

Answer 8

• Bumetanide (Bumex)
• Ethacrynic acid (Edecrin) don’t really use
• Furosemide (Lasix) MC
• Torsemide (Demadex)