Flashcards in Diuretics Deck (35):
in which part of the nephron do carbonic anhydrase inhibitors work?
for what illnesses would you use a carbonic anydrase inhibitor?
glaucoma, mountain sickness
what is an example of a carbonic anhydrase inhibitor?
dont use acetazolamide in people with _____
in which part of the nephron does Furosemide work?
what type of diuretic is furosemide?
what are some side effects of furosemide?
hypokalemia, hypomagnesemia, hypocalcemia
furosemide can also treat ___
in which part of the nephron do thizaides work?
thiazides should be used in people with ____
HTN or mild heart failure
what are some side effects of thiazides?
hypokalemia, hypomagnesemia, hypercalcemia
dont give thiazides or loops to people who have ____ allergies
which type of thiazide has a longer duration?
chlorthalidone - longer half life
thiazides can decrease the effectiveness of what drugs?
thiazides can increase the effectiveness of ____
what substances can increase the efficacy of HCTZ?
alchool, beta 2 agonists, corticosteroids
thiazides wont work on a GFR ____
what drugs work in the cortical collecting tubule?
what is the MOA for K sparing drugs?
blocks the ENAC channel resulting in cessation of K secretion
what is a side effect of K sparing drugs?
what are major contraindications for K sparing drugs?
renal failure, anyone on an ACE-I, or anyone with a GFR <10
K sparing drugs can decrease the efficacy of ______
what drugs can be used to treat female acne/hirsutism?
aldosterone antagonists - spironalactone
what is the MOA of thiazides?
blocks reabsorption of Na and Cl causing decrease in PVR and smooth muscle relaxation
what are examples of ADH antagonists?
conivaptan, tolvaptan, demeclocycline
ADH antagonists can be use in what diseases?
what is the MOA of ADH antagonists?
they stop ADH at the V1/V2 receptors
what are 2 ADH agonists?
what is the MOA of ADH agonists?
activate V1/V2 receptors and the insertion of aquaporin channels.
what disease would you use ADH agonists in?
pituitary diabetes insipidus
What is a major side effect for ADH agonists?
hyponatremia - water overload diluting your sodium levels, hypertension
describe the effect that ADH and desopressin have on urine?
reduce urine content and increase concentration
What is an example of an osmotic diuretic?
what diseases would you use mannitol in?
solute overload in rhabdo, brain edema with glaucoma