Diuretics

Question 1

HCTZ works at

Answer 1

ascending loop of Henley and distal convulsed tubule

Question 2

MOA of HCTZ

Answer 2

imparts Na+-Cl- cotransporter

Question 3

HCTZ leads to excretion of

Answer 3

Na+
Cl-
H2O
K+ -> diuresis activates RAAS

Question 4

Loop Diuretics act at

Answer 4

thick ascending loop of Henle

Question 5

Triametrene
Class
MOA

Answer 5

Triametrene
Class: potassium-sparing diuretic, epithelial sodium channel blocker , aka pteride analogs

MOA:
sodium channel blocked of luminal sodium channels in the collecting ducts.

Blocks re-uptake of sodium?

Question 6

Spirolactone works at

Answer 6

collecting ducts, blocks the actions of aldosterone and prohibits the synthesis of aldosterone-dependent basal cell Na-K-ATPase pump

Question 7

K sparing diuretics are commonly used with

Answer 7

HCTZ or other diuretics to block the potassium wasting effect

Question 8

diamox acts at

Answer 8

proximal renal tubules as well as collecting ducts

Question 9

diamox leads to

Answer 9

increased excretion of Na+, h2o, K+, and HCO3-

Question 10

Fenoldopam acts at

Answer 10

D1 - is a selective D1 receptor agonist

moderate action at alpha 2

Question 11

potassium sparing diuretics are used in patients where K+ loss is especially concerning such as

Answer 11

amiodarone - prolong QT

digoxin - increase r/f toxicity