Diuretics (Drugs) Flashcards Preview

Mechanism of Drug Action (Drugs) > Diuretics (Drugs) > Flashcards

Flashcards in Diuretics (Drugs) Deck (10)
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1
Q

What is the function of loop diuretics?

A

Blocks NKCC2 in the TAL of the loop of Henle. This reduces Na+ reabsorption.

2
Q

What are some examples of loop diuretics?

A
  1. Furosemide
  2. Bumetanide
3
Q

What is the function of thiazide diuretics?

A

Inhibits Na+-Cl- co-transport system in the TAL of the loop of Henle and the DCT.

4
Q

What are some examples of thiazide diuretics?

A
  1. Hydrochlorothiazide
  2. Bendroflumethiazide
5
Q

What are the potassium-sparing diuretics?

A
  1. Amiloride
  2. Triamterene
  3. Spironolactone
6
Q

What is the function of amiloride/triamterene?

A

Blocks ENaC channels on the apical membranes of renal tubule epithelial cells. This reduces Na+ reabsorption but has little effect on K+ reabsorption.

7
Q

What are examples of CA inhibitors?

A

Acetazolamide

8
Q

What is the function of spironolactone?

A

Inhibits action of aldosterone.

9
Q

What is the function of carbonic anhydrase inhibitors?

A

Reduces production of H+ and thus reduces Na+ reabsorption through NHE3.

10
Q

How can gout caused by diuretics be treated?

A

Probenecid (competes with uric acid for absorption in PCT and thus reduces absorption)