NT receptors

Question 1

Noradrenaline

Answer 1

1. α₁
2. α₂
3. β₁
4. β₂
5. β₃

Question 2

α₁-adrenoreceptor

Answer 2

• Type: G_q/11
• Functions:

Pupil dilation

Vasoconstriction

Salivary secretion

Decreased GI motility

Piloerection

Contraction of bladder smooth muscle

Ejaculation

Increased glycogenolysis and gluconeogenesis

Question 3

α₂-adrenoreceptor

Answer 3

• Type: G_i/o
• Functions:

Decreased NT (e.g. NA) release

Platelet aggregation

Inhibition of insulin release

Question 4

β1-adrenoreceptor

Answer 4

• Type: G_s
• Functions:

Increased force of cardiac contraction

Increased heart rate

Question 5

β2-adrenoreceptor

Answer 5

• Type: G_s
• Functions:

Bronchodilation

Vasodilation in myocardium/skeletal muscle

Relaxation of uterine smooth muscle

Gluconeogenesis

Question 6

β3-adrenoreceptor

Answer 6

• Type: G_s
• Functions:

Lipolysis

Thermogenesis

Relaxation of bladder smooth muscle

Question 7

Acetylcholine

Answer 7

Nicotinic:

1. N1
2. N2

Muscarinic:

1. M1
2. M2
3. M3
4. M4
5. M5

Question 8

M1 ACh receptor

Answer 8

• Type: G_q/11
• Functions:

Mediates synaptic transmission in CNS and PNS.

Can be found in nicotinic synapses. Binding of ACh to these cause a slow depolarisation (EPSP).

Gastric acid secretion

Question 9

M2 ACh receptor

Answer 9

• Type: G_i/o
• Functions:

Involved in parasympathetic control of the heart and feedback pre-synaptic inhibition in nerve terminals.

Question 10

M3 ACh receptor

Answer 10

• Type: G_q/11
• Functions:

Sweat secretion

Salivation

Pupil constriction

Ciliary muscle contraction

Vasodilation (via NO)

Question 11

M4 ACh receptor

Answer 11

• Type: G_q/11
• Functions:

CNS transmission

Question 12

M5 ACh receptor

Answer 12

• Type: G_q/11
• Functions:

CNS transmission

Question 13

Histamine

Answer 13

H_1-4

Question 14

Histamine H1 receptor

Answer 14

• Type: G_q/11
• Functions: Inflammatory response

Question 15

Histamine H2 receptor

Answer 15

• Type: G_s
• Functions: Gastric acid secretion

Question 16

Histamine H3 receptor

Answer 16

• Type: G_i/o
• Functions: Inhibitory CNS autoreceptor

Question 17

Histamine H4 receptor

Answer 17

• Type: G_i/o
• Functions: Chemotaxis/cytokine release

Question 18

Serotonin

Answer 18

1. 5-HT_{1A, B, D - F}
2. 5-HT_{2A - C}
3. 5-HT₃

Question 19

5-HT₁

Answer 19

Type: G_i

Question 20

5-HT₂

Answer 20

Type: G_q/11

Question 21

5-HT₃

Answer 21

LGIC

Question 22

Bradykinin

Answer 22

B_{1, 2}

Question 23

B1 bradykinin receptor

Answer 23

• Type: G_q/11
• Functions: Expressed following induction by pro-inflammatory cytokines (e.g. IL-1) and binds to des-arg-bradykinin to cause pain and vasodilation

Question 24

B2 bradykinin receptor

Answer 24

• Type: G_q/11
• Function: Expressed constitutively and binds to bradykinin/kallidin to cause vasodilation

Question 25

Tackykinins

Answer 25

- Substance P: NK1R - Neurokinin A: NK2R

Question 26

NK1R

Answer 26

- Type: G_q/11 - Functions: Mast cell degranulation Smooth muscle contraction Vasodilation Pain sensitisation

Question 27

NK2R

Answer 27

- Type: G_q/11 - Functions: Mast cell degranulation Smooth muscle contraction Vasodilation Pain sensitisation

Question 28

Lipoxins

Answer 28

FRP2

Question 29

FRP2

Answer 29

- Type: G_i/o - Functions: Antagonises effects of CysLT₁ receptors and has anti-inflammatory effects

Question 30

Leukotrienes

Answer 30

LTB4: BLT1 + BLT2 (G_q or G_i) CysLTs: CysLT₁ + CysLT₂ (G_q)

Question 31

PGD₂

Answer 31

1. DP 2. TP

Question 32

DP

Answer 32

- Type: G_s - Functions: Vasodilation Inhibition of platelet aggregation Smooth muscle relaxation (GI/uterine)

Question 33

PGE₂

Answer 33

EP_1-4

Question 34

EP1

Answer 34

- Type: G_q/11 - Functions: Bronchial/GI smooth muscle contraction

Question 35

EP2

Answer 35

- Type: G_s - Functions: Bronchodilation Vasodilation Smooth muscle relaxation (GI)

Question 36

EP3

Answer 36

- Type: G_i/o - Functions: Smooth muscle contraction (GI) Fever Inhibition of gastric acid secretion Promotion of gastric mucous secretion

Question 37

EP4

Answer 37

- Type: G_s - Sensitisation of nociceptors

Question 38

PGI₂

Answer 38

IP

Question 39

IP

Answer 39

- Type: G_s - Functions: Vasodilaton Inhibition of platelet aggregation

Question 40

PGF_2a

Answer 40

FP

Question 41

FP

Answer 41

- Type: G_q/11 - Functions: Uterine contraction

Question 42

TXA₂

Answer 42

TP

Question 43

TP

Answer 43

- Type: G_q/11 - Functions: Vasoconstriction Bronchoconstriction Platelet aggregation