DM Flashcards
1
Q
What’s biguanides MOA
A
Reduced hepatic glucose production Increase glucose uptake Gut carb absorption reduce Increase fatty acid oxidation Increase nuclear receptor expression ~> gluconeogenesis of liver increase Reduce hepatic glucose production
2
Q
What will do by biguanides when inhibit mitochondrial respiratory chain
A
Decreased hepatic energy ~> activate AMPK ~> metabolic control
