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Virology PPT > DNA > Flashcards

DNA Flashcards

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1
Q

First isolated from the culture of human adenoids and tonsils in the early 1950ss, hence the name

A

adenovirus

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2
Q

Adenovirus site of latency

A

Oropharynx

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3
Q

Adenovirus transmission

A

Respi
Fecal-oral
Direct contact (eye)

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4
Q

Adenovirus disease

A

URT
LRT
GIT
GUT

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5
Q

URT DISEASE AND SEROTYPE

A

Pharyngitis, conjunctivitis,
coryza (serotype 3, 7, 8, 19, 37)

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6
Q

LRT DISEASE AND SEROTYPE

A

bronchitis, atypical pneumonia (serotype 14)

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7
Q

GIT DISEASE AND SEROTYPE

A

acute gastroenteritis
(infantile diarrhea) [serotype: 40,
41]

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8
Q

GUT DISEASE AND SEROTYPE

A

acute hemorrhagic cystitis (serotype: 7,11,21)

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9
Q

Adenovirus incubation period

A

Respi - 2-14 days
Gastro- 3-10 days

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10
Q

Common upper R.T.I includes colds, tonsillitis,pharyngitis,pharyngoconjunctival fever, and sometimes croup

A

Adenovirus

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11
Q

Infections of the eye and conjunctivitis often accompany respiratory infection

A

Adenovirus

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12
Q

Adenovirus
in children, ___________ is often a complication of the respiratory disease

A

Otitis media

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13
Q

In adenovirus what symptom causes severe in children ?

A

Lower RTI

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14
Q

In adenovirus it is often fatal in infants and young children

A

Adenovirus pneumonia

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15
Q

Adenovirus diagnosis

A

Cell culture (Hep-2)
Cowdry type B intranuclear basophilic inclusion bodies
EIA for gastroenteritis
PCR

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16
Q

Hepadnaviridae virus

A

Hepatitis B virus ( serum hepatitis)

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17
Q

A complete virus in hepadna is also known as

A

Dane particle

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18
Q

Hepatitis B surface antigen originally called

A

Australian antigen

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19
Q

Hepatitis B transmission

A

Percutaneous exposure to blood or blood products (primary)
Parenteral
Perinatal
Direct contact

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20
Q

Hepatitis B site of latency

A

Liver

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21
Q

Hepatitis B virulence factor

A

HBsAg
HBcAG
HBeAG (infectivity)

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22
Q

Hepadnaviridae disease

A

Chronic and acute hepatits

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23
Q

Hepatitis b incubation

A

1 to 3 months or more

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24
Q

remains a significant worldwide cause of liver cirrhosis and hepatocellular carcinoma despite the availability of an effective vaccine.

A

Chronic HBV infection

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25
The only positive during window period
Anti-HBc IgM
26
The only postive among vaccinated patients
Anti- HBs
27
What can differentiate chronic active infection from chronic carrier
HBeAG
28
Chronic infection is characterized by the persistence of ________ for atleast 6 months
HBsAg
29
significant cause of liver damage associated with morbidity and mortality.
Hepatitis B
30
It is the only source of hepatitis B
Human
31
Encode many proteins that manipulate the host cell and immune response.
Herpesviridae
32
Encode enzymes (DNA polymerase) that promote viral DNA replication and are good targets for antiviral drugs
Herpesviridae
33
Herpesviridae DNA replication and capsid assembly occurs in the
Nucleus
34
Herpesviridae Virus is released by
exocytosis, by cell lysis, and through cell-to-cell bridges.
35
Ubiquitous
Herpesviridae
36
Cell-mediated immunity is required for control
Herpesviridae
37
HHV 1 HHV 2 HHV 3
1- Hepres Simplex Type 1 2- Herpes Simplex Type 2 3- Varicella-zoster virus
38
HHV 4 HHV 8
4- Epstein Barr virus 8- Kaposi sarcoma-related virus
39
HHV 5 HHV 6 HHV 7
5- Cytomegalovirus 6- Herpes lymphotropic virus 7- HHV 7
40
HSV 1&2 Transmission
Direct contact with infected secretions HSV 1- saliva or direct HSV 2- sexual or transvaginal
41
HSV 1&2 site of latency
Sensory nerve ganglia HSV 1 : Trigeminal ganglia HSV 2: Lumbosacral ganglia
42
Vesicle filled with virus particle and cell debris
HSV 1 and 2
43
Herpes Simplex Viruses (HSV) HSV-1 & HSV-2 diagnosis
Tzank smear (multinucleated giant cell) Cowdry Type A Cell culture EIA FA stain PCR
44
HHV-3
Varicella-Zoster Virus (VZV)
45
Varicella-Zoster Virus (VZV) site of latency
Dorsal root of ganglia
46
Varicella-Zoster Virus (VZV) disease
Chicken pox (varicella) Shingles (Herpes zoster) Ramsay hunt syndrome ( herpes zoster oticu) Congenital varicella
47
Varicella-Zoster Virus (VZV) prevention
VZIG vaccine Oka strain ( live attenuated vaccine)
48
Varicella is also known as
Chicken pox
49
Varicella incubation period
14-21 days
50
Varicella period of communicability
48 hours before vesicle formation and 4-5 days after until all vesicles are crusted
51
Vesicular rash ('dewdrop on a rose petal appearance') that begins on trunk; spreads to face and extremities (centrifugal) with lesions of different stages
Varicella/ Chicken pox
52
Unilateral painful vesicular eruption with a dermatomal distribution (thoracic and lumbar)
Herpes Zoster (Shingles)
53
Most common complication of Herpes Zoster/Shingles
Postherpetic neuralgia
54
Debilitating pain (postherpetic neuralgia)
Herpes Zoster ( Shingles)
55
Reactivation of latent VZV residing within geniculate ganglion
Ramsay-Hunt Syndrome( Herpes Zoster Oticus)
56
A triad of ipsilateral facial paralysis, ear pain, and vesicles on the face, on the ear, or in the ear is the typical presentation.
Ramsay Hunt Syndrome (Herpes Zoster Oticus)
57
Fetuses infected at 6-12 weeks' AOG: maximal interruption with limb development (short and malformed limbs covered with cicatrix — skin lesion with zigzag scarring associated with atrophy of the affected limb)
Congenital varicella
58
Fetuses infected at 16-20 weeks' AOG: eye and brain involvement
Congenital varicella
59
HHV-4
Epstein-Barr Virus (EBV)
60
Epstein-Barr Virus (EBV) / HHV-4 site of latency
B lymphocytes (C3d Complement)
61
Epstein-Barr Virus (EBV) / HHV-4 disease
Infectious mononucleosis (IM) (A.K.A KISSING DISEASE) Progressive lymphoreticular disease oral hairy leukoplakia in HIV-infected patients. Oncogenic: Burkitt's Lymphoma, nasopharyngeal carcinoma
62
Epstein-Barr Virus (EBV) / HHV-4 diagnosis
Serology PCR HEMATOLOGIC REPORTS (DOWNEY CELL)
63
Formerly known as: Salivary gland virus, 40-day fever
Cytomegalovirus (CMV)/ HHV-5
64
HHV 5
Cytomegalovirus
65
Cytomegalovirus (CMV)/ HHV-5 transmission
close contact with infected secretions, blood transfusion (WBCs), organ transplants, transplacental
66
Cytomegalovirus (CMV)/ HHV-5 site of latency
WBC ENDOTHELIAL CELL CELL IN VARIETY OF ORGANS
67
Cytomegalovirus (CMV)/ HHV-5 diseases
asymptomatic infections Congenital disease of newborn systemic infection of immunocompromised host heterophile negative IM
68
Cytomegalovirus (CMV)/ HHV-5 diagnosis
Cell culture (HDF) shell vial culture CMV antigenemia FA stain PCR negative heterophil test Giant cells with "owl's-eye" nuclear inclusion
69
Human Herpesvirus 6 and 7 (HHV-6 and HHV 7) site of latency
T lymphocytes (CD4)
70
Human Herpesvirus 6 and 7 (HHV-6 and HHV 7) diseases
Roseola (roseola infantum/exanthem subitum/6th disease) fever malaise, rash, leukopenia, and interstitial pneumonitis in organ transplant patients
71
What human herpes virus usually infects children
Human herpes 6
72
Human herpesvirus type 8 (HHV-8) site of latency
viral genome found in Kaposi's sarcoma tumor cells, endothelial cells, and tumor infiltrating leukocytes
73
Human herpesvirus type 8 (HHV-8) disease
Kaposi sarcoma
74
Only virus with fiber
Adenovirus
75
Cowdry type B intranuclear basophilic inclusion bodies
Adenovirus
76
Temporal lobe encephalitis
HSV 1
77
Genital herpes Neonatal herpes (TORCH) Aseptic meningitis
HSV 2
78
Tzanck smear (multinucleated giant cells)
Herpes Simplex Viruses (HSV)
79
Cowdry Type A eosinophilic intranuclear inclusions
Herpes Simplex Viruses (HSV)
80
is the most common cause of sporadic, fatal encephalitis in the USA
HSV- 1
81
HSV principal target area of the virus
Temporal lobe
82
owl’s-eye nuclear inclusion
Cytomegalovirus/HHV 5
83
Heterophil-Negative:
Cytomegalovirus Toxopasma
84
Heterophil-Positive
Epstein-Barr Virus
85
Differential white blood cells count will show elevated “atypical lymphocytes” Downey cells
Epstein-Barr Virus (EBV) / HHV-4
86
‘Kissing disease
Infectious mononucleosis
87
Monospot-positive/heterophil-positive
IM- Epstein-Barr Virus (EBV) / HHV-4
88
6th disease
ROSEOLA / EXANTHEM SUBITUM
89
erythematous papules on soft palate and base of the uvula
Nagayama spots
90
Nagayama spots
HHV 6
91
î most common AIDS-related malignancy
Kaposi sarcoma
92
Dark/violaceous plaques or nodules representing vascular proliferations
Kaposi sarcoma
93
the only DNA virus that produces DNA by reverse transcription with mRNA as the template; not a retrovirus but has reverse transcriptase
Hepatitis B Virus
94
hepatocellular injury due to immune attack by cytotoxic T cells
Hepatitis B Virus
95
Used as marker of potential infectivity
e antigen (HBeAg)
96
Liver biopsy for Hepatitis B
Granular HEPATITIS B INFECTION eosinophilic “ground glass” appearance
97
eosinophilic globule of cells that represents a dying hepatocyte often surrounded by normal parenchyma
Councilman body:

Virology PPT (7 decks)

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