DNA Viruses Flashcards
(15 cards)
DNA viruses
what ones?
are dsDNA viruses except?
have linear genomes except?
are icosahedral except?
replicate in nucleus except?
Hepadna, Herpes, Adeno, Pox, Papilloma, Parvo, Polyoma
parvo (ssDNA)
papilloma & polyoma (complete, supercoiled)
hepadna (incomplete, circular)
pox - complex
pox (carries DNA dependent RNA polymerase)
Naked viruses
DNA?
RNA?
other?
DNA:
adeno, papilloma, parvo, polyoma
RNA:
calici, picorno, reo
Hepevirus
Poxvirus
p/w
linear, dsDNA, complex, replicates outside nucleus
smallpox - now vaccine
cowpox - “milkmaid blisters”
mollucum contagiosum - flesh color papule w/ central umbilication
Hepadna virus
incomplete circular dsDNA, has rt
actue vs chronic HBV
Adenovirus
non-encapsulated, linear dsDNA virus
p/w febrile pharyngitis, acute hemorrhagic cystitis, PNA, conjuntivitis, gastroenteritis, myocarditis
Papillomavirus
non-encapsulated supercoild dsDNA virus
1,2,6,11 - condylomata accumata
16,18 - CIN, cervical CA
Polyomavirus
JC & BK virus p/w
non-encapsulated supercoiled dsDNA virus
JC virus - p/w progressive multifocal leukeoencephalopathy in HIV
BK virus - target kidneys in transplant pts
Parvovirus
receptor
fetus
children
adults
sickle cell patients
non-encapsulated ssDNA virus; P antigen on RBC
hydrops fetalis
fifths disease: slapped cheeks/erythema infectiosum
pure red cell aplasia & RA like joint sx
aplastic crisis
HSV1
tranmission
p/w
w/u
enveloped linear dsDNA
respiratory, saliva
gingivostomatitis, keratoconjunctivitis, herpetic whitlow on finger, erythema multiforme, herpes labialis, temporal lobe encephalitis
more commonly latent in trigeminal ganglia
intranuclear eosinophilic cowdry A inclusions
Tzanck test - multinucleated giant cell in open vesicle
CSF PCR for herpes encephalitis
viral cx for skin/genetalia
HSV2
tranmission
p/w
enveloped linear dsDNA
sexual contact, perinatal
herpes genitalis, neonatal herpes
more commonly latent in sacral ganglia
intranuclear eosinophilic cowdry A inclusions
VZV (HHV-3)
tranmission
p/w
inclusions
enveloped linear dsDNA
respiratory secretions
chicken pox, shingles, PNA, encephalitis
intranuclear eosinophilic cowdry A inclusions
EBV (HHV-4)
receptor
tranmission
p/w mononucleosis
a/w
if use amoxacillin
enveloped linear dsDNA
respiratory secretions, saliva; infect b cells via CD21
=> atypical lymphocytes (reactive cytotoxic T cells)
mononucleosis
= fever, HSM, pharyngitis, LAD
a/w burkitt lymphoma, nasopharyngeal carcinoma, lymphoproliferative dx in transplant pts
amoxacillin => maculopapular rash
CMV (HHV-5)
receptor
tranmission
p/w adult - immunocompetent
p/w adult - immunocompromised
p/w congenital
cells look like
remains latent where?
enveloped linear dsDNA; integrins (heparin sulfate)
saliva, urine transplant, sexual, congenital infusion
p/w adult - immunocompetent: mononucleosis w/ -monospot test
p/w adult - immunocompromised: PNA, esophogitis, AIDs, retinitis (hemorrhage, vision loss, cotton wool exudates)
p/w congenital - sensorineural deafness, chorioretinitis, periventricular plaques, HSM & jaundice, “blueberry muffin” rash
owl eye intranuclear inclusions
latent in mononuclear cells
HHV-6/7
tranmission
p/w roseola
enveloped linear dsDNA
saliva
roseola infantum/exanthem subitum (fever first, rash later)
= high fever for several days followed by diffuse macular rash (fever can cause seizures)
HHV-8
tranmission
p/w Kaposi sarcoma
enveloped linear dsDNA
sexual contact
kaposi sarcoma = neoplasm of endothelial cells
dark, violacious plaques or nodules
can effect GI tract and lugs as well
