DNA VIRUSES PART 2: POXVIRUS

Question 1

Subtype of Small pox which caused the most severe disease with case fatality of 30% and occurred mainly in Asia

Answer 1

Variola Major

Question 2

Pox virus infection that is systemic infection that spreads the virus throughout the body

Answer 2

Fulminant

Question 3

Transmission of smallpox

Answer 3

Respiratory droplets

Question 4

Transmission of molluscum, orf, monkeypox

Answer 4

Direct contact

Question 5

Zoonoses viruses of poxviridae

Answer 5

Orf and monkeypox

Question 6

Intact form of the virion of poxvirus from a vesical fluid specimen

Answer 6

Mulberry form

Question 7

Damaged form of the virion of poxvirus from a scalp specimen

Answer 7

Capsule form

Question 8

Give the code of the anti viral tx: Brimcidofovir/Tembexa

Answer 8

CMX001

Question 9

Give the code of the antiviral tx: Tecovirimat/Tpoxx

Answer 9

ST246

Question 10

Incubation period of variola virus

Answer 10

10-17 days

Question 11

Lesions are present in greater concentration on the head and limbs including the palms and soles

Answer 11

Centrifugal distribution

Question 12

Rash: small, round changes in skin color

Answer 12

Macules

Question 13

Rash: slightly elevated with no fluid

Answer 13

Papules

Question 14

Rash: containing a bubble of fluid

Answer 14

Vesicles

Question 15

Rash: containing a purulent material consisting of necrotic inflammatory cells

Answer 15

Pustules

Question 16

Vaccines for Variola virus

Answer 16

ACAM2000, ARSV (Aventis Pasteur Smallpox Vaccine)

Question 17

Patients with Variola virus are infectious after the _ has appeared

Answer 17

Rash

Question 18

Rash appears in

Answer 18

24-48hrs (1-2days)

Question 19

A Jennerian vaccine named for Edward Jenner in 1796(1798)

Answer 19

Vaccinia

Question 20

Considered a bioterrorism agent

Answer 20

Smallpox

Question 21

Smallpox is caused by Variola virus characterized by

Answer 21

Vesicular and pustular eruption

Question 22

Causative agent: Variola Virus
* Centrifugal distribution
* Most dense on face and
extremities
* Lesions appear during a 1– 2 day
period
* Lesions evolve at the same rate

Answer 22

Classic Smallpox Rash

Question 23

Distribution of chickenpox

Answer 23

Centripetal

Question 24

subtype of ordinary type smallpox rash
* have distinct areas of normal skin between discrete pustules

Answer 24

Discrete subtype

Question 25

subtype of ordinary smallpox rash * have a confluent rash on the face but with discrete lesions elsewhere

Answer 25

Semi-confluent subtype

Question 26

Subtype rash of ordinary type smallpox - confluent rash on the face and the extremities

Answer 26

Confluent subtype

Question 27

3 Major Classifications of Smallpox: *More rapidly progressive, malignant disease develops, which is almost always fatal within 5 to 7 days. * Characterized by a severely prostrating prodromal illness with high fever, head ache, back pain, and abdominal pain. * difficult to diagnose, and they are exceedingly

Answer 27

Hemorrhagic

Question 28

3 Major Classifications of Smallpox: characterized by a more abrupt onset of illness and prostration than classical smallpox. * confluent lesions develop slowly, never progressing to the pustular stage, remaining soft, flattened, and velvety to the touch. * Invariably fatal * However, if an individual survives flat smallpox, they rarely experience typical scarring afterward

Answer 28

Malignant (Flat)

Question 29

Causative agent of Alastrim

Answer 29

Variola minor

Question 30

Complication: Chronic Viral Conjunctivitis

Answer 30

Vaccinia Virus

Question 31

derivative of vaccinia virus that has persisted in in India in water buffalo

Answer 31

Buffalopox virus

Question 32

Host reservoir of Monkeypox

Answer 32

Gambian rats

Question 33

caused by an orthopox virus

Answer 33

Monkeypox

Question 34

Monkeypox commonly occurs in

Answer 34

West and central Africa

Question 35

Clades of monkeypox that has the highest fatality rate

Answer 35

Congo Basin Clade

Question 36

Characteristic feature of Monkeypox

Answer 36

Inguinal lymphadenopathy

Question 37

Incubation period of monkeypox

Answer 37

7–17 days

Question 38

The vesicular rash appears about

Answer 38

3-5 days later

Question 39

a close relative to the vaccinia virus used for smallpox vaccination

Answer 39

Cowpox

Question 40

commonly transmitted to farmworkers from cows

Answer 40

Cowpox

Question 41

Cowpox incubation period

Answer 41

9–10 days

Question 42

Cowpox virus can be distinguished from vaccinia virus by

Answer 42

deep red hemorrhagic lesions

Question 43

sheep and goat handlers

Answer 43

orf

Question 44

cows (milker’s node)

Answer 44

Pseudocowpox

Question 45

benign epidermal tumor that occurs only in humans

Answer 45

Molluscum contagiosum

Question 46

oval or brickshaped and measures 230 × 330 nm; it resembles vaccinia

Answer 46

Molluscum contagiosum

Question 47

Africa, mainly in Kenya and the Democratic Republic of congo

Answer 47

Tanapox

Question 48

Tanapox natural host

Answer 48

monkeys

Question 49

causes benign histiocytomas

Answer 49

Yaba monkey tumor poxvirus