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Mycology and Virology > DNAV: Herpesviridae > Flashcards

DNAV: Herpesviridae Flashcards

(53 cards)

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1
Q

What are the viruses found in the herpesviridae family?

A

Herpes Simplex 1 and 2
Varicella-Zoster
Epstein-Barr
Cytomegalovirus
Human Herpesvirus 6, 7, and 8

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2
Q

Which laboratory techniques can detect viral antigens of Herpes Simplex Virus 1?

A

Immunofluorescence or Immunoperoxidase

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3
Q

Which molecular method is commonly used to detect Herpes Simplex Virus 1 DNA?

A

Polymerase Chain Reaction

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4
Q

Which cell lines are commonly used for Herpes Simplex Virus 1 culture?

A

HeLa, fibroblasts, rabbit kidney cells

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5
Q

Which direct examination methods can identify Herpes Simplex Virus 1?

A

Pap smear or electron microscopy

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6
Q

What type of capsid does Herpes Simplex Virus 1 have?

A

Icosahedral

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7
Q

Where does Herpes Simplex Virus 1 establish latency?

A

Trigeminal ganglia

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8
Q

Which cytopathic effects are characteristic of Herpes Simplex Virus 1?

A

Multinucleated giant cells and intranuclear inclusions

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9
Q

What is the common name for an oral infection caused by Herpes Simplex Virus 1?

A

Cold sores

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10
Q

Which eye infection is associated with Herpes Simplex Virus 1?

A

Herpetic keratitis

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11
Q

What differentiates Herpes Simplex Virus 2 from Herpes Simplex Virus 1 in molecular testing?

A

Specific DNA primers or probes

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12
Q

What is the primary anatomical tropism of Herpes Simplex Virus 2?

A

Genital region

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13
Q

Which type of cancer is associated with Herpes Simplex Virus 2?

A

Cervical carcinoma

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14
Q

Which neurological disease can be caused by Herpes Simplex Virus 2?

A

Sporadic encephalitis

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15
Q

Which neonatal condition is caused by Herpes Simplex Virus 2?

A

Neonatal HSV infections

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16
Q

Which cytology findings are characteristic of Varicella-Zoster Virus?

A

Intranuclear inclusions and multinucleated giant cells

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17
Q

Which laboratory tests detect antibodies against Varicella-Zoster Virus?

A

Serological tests

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18
Q

Which molecular test is commonly used for Varicella-Zoster Virus detection?

A

Polymerase Chain Reaction

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19
Q

Which type of vaccine is available for Varicella-Zoster Virus?

A

Live attenuated vaccine

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20
Q

What is the characteristic rash seen in Varicella-Zoster Virus infection?

A

Dewdrop-on-rose-petal lesions

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21
Q

Which disease results from reactivation of Varicella-Zoster Virus?

A

Shingles (Herpes zoster)

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22
Q

What is the primary disease caused by initial infection with Varicella-Zoster Virus?

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A

Chickenpox (Varicella)

23
Q

Which molecular technique is commonly used to detect Epstein-Barr Virus?

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A

Polymerase Chain Reaction

24
Q

Which test detects heterophile antibodies in Epstein-Barr Virus infections?

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A

Monospot test

25
What type of envelope does Epstein-Barr Virus have?
Enveloped
26
Which lymphoma is strongly associated with Epstein-Barr Virus?
Burkitt’s lymphoma
27
Which type of carcinoma is linked to Epstein-Barr Virus infection?
Nasopharyngeal carcinoma
28
Which disease caused by Epstein-Barr Virus is also known as the kissing disease?
Infectious mononucleosis
29
Which direct cytology finding is characteristic of Cytomegalovirus infection?
Owl-eye inclusions
30
Which molecular test is commonly used for Cytomegalovirus detection?
Polymerase Chain Reaction
31
Which antigen detection methods are used for Cytomegalovirus?
Immunofluorescence and enzyme-linked immunoassay
32
Which type of cell culture is used for Cytomegalovirus isolation?
Fibroblasts
33
What is the structural classification of Cytomegalovirus?
Enveloped
34
Which herpesvirus is the largest in size?
Cytomegalovirus
35
Which type of infection is commonly caused by congenital Cytomegalovirus transmission?
Congenital infections
36
Which mononucleosis-like illness can be caused by Cytomegalovirus?
CMV mononucleosis
37
Which patient group is at high risk for Cytomegalovirus complications?
Transplant patients
38
Which molecular method is used to detect Human Herpesvirus 6?
Polymerase Chain Reaction
39
What is the envelope status of Human Herpesvirus 6?
Enveloped
40
Which childhood disease is caused by Human Herpesvirus 6?
Roseola (Exanthem subitum)
41
Which neurological complication is associated with Human Herpesvirus 6 infection in children?
Febrile seizures
42
What type of genetic material does Human Herpesvirus 6 contain?
Double-stranded DNA
43
Which immune cells are primarily infected by Human Herpesvirus 6?
T-cells
44
Which childhood disease is commonly caused by Human Herpesvirus 6 and 7?
Roseola
45
Which mononucleosis-like illness can be caused by Human Herpesvirus 6?
Some cases of mononucleosis
46
Which laboratory method is used for visualizing Human Herpesvirus 6 and 7 particles?
Electron microscopy
47
Which human herpesvirus is most similar to Human Herpesvirus 6?
Human Herpesvirus 7
48
What is the envelope status of Human Herpesvirus 8?
Enveloped
49
Which cell surface receptor does Human Herpesvirus 8 use for entry?
CD4
50
Which cancer is strongly associated with Human Herpesvirus 8 infection?
Kaposi’s sarcoma
51
Which group of patients is at high risk for Human Herpesvirus 8-associated Kaposi’s sarcoma?
AIDS patients
52
Which molecular technique is commonly used to detect Human Herpesvirus 8?
Polymerase Chain Reaction
53
Which type of biopsy is used for detecting Human Herpesvirus 8 in Kaposi’s sarcoma lesions?
Kaposi’s sarcoma biopsy

Mycology and Virology (21 decks)

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