DONE: Botanicals Flashcards

Listed in alphabetical order. Main concepts at the end of the list marked with ZZ. (176 cards)

1
Q

Achillea millefolium

  • actions?
  • indications?
  • contraindications and AEs d/t?
A

Yarrow flowers asteraceae family
- bitter digestive stimulant, vulnerary, styptic/hemostatic, anti-inflammatory, diaphoretic

topical: wound and skin ulcers
internal: passive hemorrhage, meno or metrorrhagia, hematuria, anal or uterine hemorrhoids, cystitis, leukorrhea, poor digestion, fever, URTIs, joint pain

AEs: *thujone is an emmenagogue, abortifacient, and can cause convulsions

contraindicated: *b/c it is a bitter digestive: GERD< PUD, gastritis, biliary obstruction, acute cholelithiais, diarrhea. *avoid large doses in pregnancy
interacts: PPIs

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2
Q

Aconitum napellus

  • effects
  • effect on the heart
A

Monkshood root or leaf low dose herb

  • sensory and motor depressant: aconitine raises Na ion permeability and slows repol: it is initially stimulating, then causes paralysis
  • sedative
  • anti-pyretic

high doses: positive inotropic effect, then tachycardia, cardiac arrhythmia, cardiac arrest

indicated: trigeminal and intercostal neuralgia, fever, chills

side effects: highly toxic, tingling, decrease in body temperature

contraindicated: pregnancy, lactation

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3
Q

Actea (Cimicifuga) racemosa

  • mimetic of what hormone?
  • indicated?
  • contraindicated?
  • used with what pharmaceutical to decrease its SEs?
A

Black cohosh root
- uterine tonic, pituitary and estrogen mimetic, parturifacient, anti-rheumatic, spasmolytic, antitussive, nervine

indicated: dysmenorrhea, PMS, menopause, early labor, rheumatism, myalgia, OA and RA, whooping cough

AEs: in overdose: sedative, bradycardia, hypotension, blurred vision, N/V, HA

contraindicated: 1st TM of pregnancy and lactation, estrogen dependent tumors
interacts: HRT > excess estrogen that does NOT affect the uterus. reduces hot-flushes from tamoxifen

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4
Q

Aesculus hippocastanum

- used topically for? internally for?

A

Horse Chestnut leaves
- astringent, vasocontrictive, veno-tonic, anti-inflammatory, mild expectorant

topical: hemorrhoids, pruritis ani, varicose veins, nocturnal leg swelling
internal: venous insufficiency, DVT, varicose veins, thrombophlebitis, edema, chronic prostatitis

AEs: Nausea, unprocessed fruit is highly toxic

contraindications: high dose

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5
Q

Allium cepa

  • what is it?
  • name 4 actions?
  • contraindicated in what 2 diseases?
  • contraindicated with what therapy?
A

onion bulb

  • antimicrobial (staph)
  • reduces plt aggregation, LDL antioxidant, inhibits COX and LOX (decreases leukotrienes)
  • hypoglycemic: disulphides (make you cry): ADPS increases the 1/2 life of insulin, increases insulin secretion, and increases hepatic metabolism of glucose
  • carminative

indicated:

internal: urinary infections (urgency, pus, hematuria, stones), elevated cholesterol or blood pressure, platelet aggregation, inflammatory conditions, elevated blood glucose
external: dermatophytosis, onychomycosis, warts, vaginitis, otitis media

contraindicated: hypothyroidism (raw/disulphides reduce iodine uptake), bleeding disorders, anticoagulant therapy
interactions: warfarin, insulin, metformin, glyburide. rosiglitazone

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6
Q

Allium sativum

  • what is it?
  • 3 actions?
A

garlic bulb, oil

  • antimicrobial (fungus, protozoa, and bacteria)
  • hypotensive
  • hypolipidemic

indicated: URTIs with cough/catarrh/pertussis/otitis media, parasites (worms and candidiasis), high cholesterol and lipids (reduces serum chol and TGs, raises HDL), intermittent claudication, HTN, heart attack and stroke prevention
caution: might potentiate anticoagulants

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7
Q

Aloe vera

- explain difference between inner and outer

A

(outer): cathartic

gel (inner): vulnerary, inflammation and immune modulator, demulcent

  • external: burns, wounds, frost bite, ulcerations, stretch marks, warts, varicose veins
  • internal: gastritis, IBD, peptic ulcer, interstitial or infectious cramping
  • dont use in 3rd degree burns, deep/infected wounds, or wounds healing by 2ary intention

interacts: glyburide

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8
Q

Althaea officinalis

  • indicated for?
  • take away from other oral drugs how many hours?
A

Marsh Mallow
demulcent - urinary and GI, emolient, vulnerary, anti-inflammatory

indicated for uncomplicated cystitis (not pyeloneph), gastric inflammation, oral and pharyngeal irritation

CI: profuse catarrh or congestion of mucous membranes

take away from all other drugs 2 hours

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9
Q

Angelica sinensis

  • indicated for?
  • AEs with which pharm?
  • dont use in?
A

Dong Quai root
- uterine tonic , liver tonic, spasmolytic, anti-inflamatory, analgesic, sedative

indicated: amenorrhea, dysmenorrhea, endometritis, estrogen imbalance, menopause, PMS, uterine tonic, liver, digestion, WHOLE BODY HERB

AEs: fever, GI, increased bleeding *monitor PT/INR in those taking blood thinners, photodermatitis

contraindicated: hemorrhagic disease, hypermenorrhea, chronic diarrhea, abd bloating, acute infection, pregnancy
interacts: warfarin

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10
Q

Arctium lappa

  • contraindicated?
  • indicated?
A

Burdock Root asteraceae family
Bitter, hepatoprotective, alterative, diuretic (avoid with Lithium), hypoglycemic

indicated: inflammatory and hormonal skin conditions - acne, stimulates digestive juice secretion, helps with appetite and anorexia nervosa, dry/scaly skin patches like eczema, psoriasis, dandruff
topical leaves: mastitis, OA, RA, sprains

AEs: nausea

interacts: additive effect with insulin

CI: asteraceae

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11
Q

Arctostaphylos uva-ursi

  • class?
  • what kind of UTIs?
  • what two constituents does it contain?
  • take away from these 3 supplements?
A

Uva Ursi, Bearberry leaves
renal antimicrobial, not a diuretic

indicated for uncomplicated cystitis (not pyeloneph), alkaline UTIs, chronic bladder irritation with pain, tenesmus, blood and mucus

AEs: high tannins could cause GI discomfort. extended use esp in children > liver damage due to hydroxyquinones

contraindicated: pregnancy > 10 days, kidney disorders
interactions: tannins iron. avoid use with anything that acidifies the urine as this reduces the antimicrobial effect of the hydroxuquinones (vitamin C and cranberry)

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12
Q

Arnica montana

- used when?

A

Arnica flower Asteraceae family
- topical antiinflammatory, vulnerary, immune stimulant

used externally for bruises and to reduce pain, phlebitis, rheumatism, strains and sprains, myalgia

do not use in large open wounds > risk of toxicity

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13
Q

Artemesia absinthum

  • indicated for?
  • what makes it different from other artemesias?
  • large doses/continuous doses?
  • take away from what pharm? what supplement?
A

Wormwood leaf asteraceae family
bitter, carminative, antimicrobial, antidepressant

indicated: weak digestion, dyspepsia, stomach pain, colic, gas, *round worm and pinworms, depression, colds, influenza

AEs: dont take continuously, large doses of thujone can lead to vomiting, cramps, headache, dizziness, etc

CI: seizures, ulcers, pregnancy, breastfeeding

interacts: PPIs, Iron (separate by 1-2 hours)

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14
Q

Artemesia annua

  • indicated?
  • what makes it different from other artemesias?
  • combine with what supplement for optimal efficacy
A

Annual Wormwood root and leaf asteraceae family
- antiparasitic, antimicrobial, antineoplastic, bitter

Indicated: infection, *plasmodium/malaria, *cancer - leukemia and colon cancer

AEs: allergies or contact dermatitis

contraindicated: pregnancy, lactation, aster allergy

you SHOULD combine with iron for optimal efficacy!

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15
Q

Artemesia vulgaris

  • what makes it different from other artemesias?
  • contraindicated?
A

Mugwort root asteraceae family
bitter and nervine tonic, carminative, emmenagogue, nootropic is diff effect

indicatied: poor digestion, depression, amenorrhea

AEs: thujone is an emmenagogue, abortifacient, and can cause convulsion

contraindicated: GERD, active ulcers, gastritis, biliary obstruction, cholelithiasis, diarrhea, *pregnancy, lactation, asteraceae
interacts: PPIs, hypoglycemics

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16
Q

Asclepius tuberosa

  • actions?
  • indicated?
  • contraindicated?
  • interactions?
A

Pleurisy root
- diaphoretic, expectorant, antitussive, antispasmodic

indicated: infection, respiratory tract congestion (bronchitis, pleurisy, pertussis, pneumonia, cough, common cold, flu)

Aes: nausea and upset stomach

contraindicated: pregnancy, large doses for several days
interacts: cardiac glycosides

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17
Q

Aspidosperma quebracho

- indicated for? contraindicated?

A

Quebracho bark low dose herb
stimulating expectorant used in wet cough to promote expectoration. antitussive, antimicrobial

indicated: wet cough, dyspnea, asthma, emphysema, TB, hemoptysis, bronchitis, pneumonia

AEs: salivation, sweating, vertigo, stupor, OD = N/V

contraindicated in dry cough (same as sanguinaria, lobelia)

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18
Q

Astragalus membranaceus

  • actions?
  • could effect blood how?
  • dont use in?
A

Astragalus, Huang Qi
- Adaptogen and immune modulating, antibacterial, viral, hepatoprotective, cardioprotective, hypoglycemic

indicated: deep immune system, allergies, resp infections, cancer

Aes: could increase fibrin formation

contraindicated in autoimmune conditions

interacts: acyclovir, IFN 1 and 2, corticosteroids

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19
Q

Atropa belladonna

  • class?
  • effects on heart?
  • adverse effects?
  • interacts with which class?
A

Belladonna leaves and root
contains tropane alkaloids atropine low dose herb

  • anticholinergic, parasympatholytic = competitive antagonism of Ach
  • spasmolytic, positive dromotropic, positive chronotropic, vasoconstrictor, smooth muscle inhibitor, bronchodilator

indicated: liver and GB complaints, smooth muscle

AEs: hot as a hare, red as a beet, dry as a bone, blind as a bat, mad as a hatter

contraindications: long-term use, high doses, BPH, urinary retention, prostate CA, tachycardia, arrhythmia, closed-angle glaucoma, GI stenosis, megacolon, pregnancy, lactation, children
interacts: potentiates anticholinergic drugs - atropine, bupropion, dextromethorphan, dicyclomine, diphenhydramine, tiotropium bromide, tolterodine, TCAs

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20
Q

Avena Sativa

  • classes
  • contraindicated in which pt population?
  • what class of meds does it effect absorption?
A

Oat seed
- nervine, nutritive, mild sedative

Beta-glucans in oat gum can increase food viscosity and peak post-prandial glucose, increases bile excretion and decreases lipids

indicated for:

internal: fatigue, anxiety, debility, autoimmune conditions like MS, rheumatism, insomnia, nicotine or opiate withdrawal
external: anodyne, eczema

contraindications: people with celiac disease
interactions: oat bran could effect absorption of statins - eat it 2 hours before or 4-6 hours after taking

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21
Q

Bacopa monnieri

- indications and class

A

bacopa aerial parts
-antioxidant, neuroprotective, inhibits ACHesterase, increases cerebral blood flow

indicated: cognition, anxiety, epilepsy, poor memory

AEs: palpitations, nausea, dry mouth, thirst

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22
Q

Baptisia tinctoria

  • use in combo with which 2 herbs?
  • effect on WBC?
A

Wild Indigo root low dose herb

  • raises leukocyte count, immune stimulating, antiviral when in combination w echinacea and thuja
  • antimicrobial, anti-catarrhal, alterative

indicated: infection, URIs with catarrh, pharyngitis, tonsilitis, mastitis, delirium, chronic fatigue

AEs: GI upset

CI: long term and high dose, pregnancy and lactation

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23
Q

Berberis (Mahonia) aquifolium

- indications different from vulgaris

A

Oregon Grape root
hepatic, antibiotic (not antiviral), bitter, alterative, cholagogue

indicated: poor digestion, chronic skin disease, acne, candida, mastitis, gastroenteritis, H pylori, hepatitis, lower UTI, vaginitis

AEs: N/V, hypotension, HF, convulsions, paresthesias

contraindicated: anything contraindicated in bitter digestive stimulants, late pregnancy
interacts: PPIs

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24
Q

Berberis vulgaris

- indications different from aquifolium

A

Barberry fruit and root bark
hepatic, bitter, cholagogue, choleretic, antimicrobial
hypoglycemic agent (berberine), berberine = metformin in some studies for reducing blood glucose

indicated: poor digestion, gastritis, H pylori, gastroenteritis, chronic hepatitis, liver disease, gallstones, malaria, splenomegaly

AEs: N/V, hypotension, HF, convulsions, paresthesias

contraindicated: anything contraindicated in bitter digestive stimulants, late pregnancy
interacts: PPIs

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25
Boswellia serrata - when is it used? - enhances which drugs?
Frankincense gum resin anti-inflammatory, circulatory stimulant, analgesic, antiseptic, astringent indicated for: ulcerative colitis, OA, crohns, RA, chronic prostatits, inflammation, asthma AEs: take with water and food to avoid GI irritation *enhances NSAIDs - ASA, ibuprofen, naproxen and celecoxib
26
Bryonia alba/cretica dioica - used for? - how many berries would kill an adult and child? - contraindicated?
White and Red Bryony root **low dose herb** - anodyne, sedative, antirheumatic, antiviral, cathartic indicated: painful rheumatism, laxative, emetic, diuretic, ulcers, asthma, bronchitis AEs: OD > vomiting, diarrhea, colic, collapse, paralysis *40. berries would kill and adult, 15 would kill a child* contraindicated: pregnancy, lactation, internal use
27
Calendula officinalis - indications - contraindications?
Calendula, Marigold flower **Asteraceae family** - anti-inflammatory, vulnerary, mild antibacterial *it promotes the formation of granulation tissue > important for epithelization and healing of wounds* indicated: skin conditions, surgical wounds, gingivitis, oral ulcers, varicose veins. (can be used internally for gastric ulcers) CI: deep wounds, aster allergy
28
Camellia sinensis - what does it contain? - interacts with which class?
green tea leaf antioxidant and anti-inflammatory, anti-neoplastic, antimicrobial, diuretic, *contains purine alkaloids* indicated: cancer and dental cavity prevention AEs: gi irritation, reduced appetite, constipation or diarrhea - can avoid these by adding milk to tea contraindicated: weakened cardio system, renal disease, thyroid hyperfunctioning, anxiety and anxiety-like disorders d/t stimulant. avoid in pregnancy and breastfeeding due to caffeine content interactions: reduces effectiveness of anticoags
29
Cannabis sativa - which two situations is it most beneficial in? - issue with non pharm versions? - with which med is there a serious side effect? what is it?
Marijuana demulcent, analgesic, sedative, antiemetic, psychoactive, anti-inflammatory, hypotensive indicated: appetite stimulant, antiemetic (AIDS, CA) side effects: dizziness, euphoria, laughing fits, paranoid, somnolence, abnormal thinking * could be contaminated with aspergillus if not pharm CI: pregnancy C, breastfeeding, schizophrenia interacts: sildenafil > MI, CNS depressants, alcohol
30
Capsella bursa-pastoris - actions? - indicated? - contraindicated? - interacts?
Shepherd's Purse aerial styptic, astringent indicated: nosebleeds, hemorrhage, wounds and burns contraindicated: pregnancy interacts: warfarin
31
Capsicum frutescens - what is it? - contraindicated? - interacts with what drug?
cayenne ground dried fruit - circulatory and vasomotor stimulant: lowers chol, TG, and LDL:HDL, decreases plt agg - rubefacient/counterirritant - gastric stimulant - antimicrobial - anti-inflammatory: stimulates production of collagenase (OA, RA), depletes substance P (pain transmission in C-fibers decreased) indicated: external: diabetic neuropathy, pruritis, psoriasis, OA, RA, migraines internal: hypochlorhydria, H pylori, maldigestion, dyspepsia, biliary insufficiency, atonic constipation, atherosclerosis, GI or resp infection, hypercoagulation contraindicated: pregnancy - uterine stimulant interactions: compounds dry cough side effect of ACEIs
32
Cassia angustufolia (Senna alexandrina) - how does it work? - weird side effects? - pregnancy?
Senna stimulating laxative, cathartic *inhibits water and electrolyte absorption from the large intestine > increases volume and pressure of intestinal contents > stimulates colon motility* indicated: constipation AEs: harmless red urine or feces, colic, pseudomelanosis coli, diarrhea, abortion contraindicated: obstruction, acute inflamm disease, appendicitis, pregnancy interactions: avoid hypoK drugs
33
Caulophyllum thalictroides - treats? contraindicated? - dont use with what pharm?
Blue cohosh rhizome - uterine tonic, parturifacient, emmenagogue, anti-inflammatory, antirheumatic, diuretic, diaphoretic indicated: amenorrhea, menorrhagia, metrorrhaggia, dysmenorrhea, cyclic mastalgia, female infertility, uterine prolapse, to facilitate labor, rheumatism, OA, RA AEs: dermatitis, GI irritation CI: pregnancy interacts: nitroglycerin
34
Ceanothus americanus - contains? which does ? - tonic to which organ?
New Jersey Tea - tannins have astringent effect: reduced blood clotting time, also an expectorant and antispasmodic. spleen tonic, hypotensive, sedative indicated: fatty liver, hepatitis, splenomegaly, LAD, bronchitis, asthma, cough, dysentery, GI bleeds, skin irritation and sores interacts: could antagonize anticoagulants
35
Centella asiatica - class - used in which emergency scenario? - side effect on labs? - pregnancy?
Gotu Kola whole plant - nervine, antipyretic indicated: nervousness, poor memory, epilepsy, venous insufficiency externally: inflamed skin, ulcers, psoriasis, snake bite poultice AEs: photosensitization, DM or HLD (could increase blood glucose and lipids), possible infertility contraindicated: pregnancy
36
Chamaelirium luteum - tonic for which 2 organs? - indications? - contraindicated? - pharm interaction?
false unicorn root -uterine and ovarian tonic, emmenagogue, diuretic indicated: amenorrhea, dysmenorrhea, endometriosis, leukorrhea, estrogen imbalance, menopause, female infertility, uterine infection, ovarian cysts, leiomyoma, PMS, threatened miscarriage, premature labor, dyspepsia AEs: N/V, anti-plt contraindicated: early pregnancy, GI irritation interacts: warfarin
37
Chelidonium majus - actions - topically for? internally? - contraindicated?
Greater celandine aerial parts, roots and rhizome -alterative, choleretic, cholagogue, bitter, diuretic, anti-inflammatory, mild antitussive, anitmicrobial, antiviral (HPV) topical: warts, eczema, corns, malignant tumors internal: biliary insufficiency, prevent gall stones, whooping coug, asthma CI: biliary obstruction, hepatic failure, acute diarrhea, cholelothiasis, hepatitis, chlecystitis, conconjugated hyperBRemia, pregancy, lactation, children
38
Chionanthus virginicus | - indications?
Fringe Tree dried root or tree bark - cholagogue, alterative, bitter, diuretic topical: wounds and inflammation internal: liver and gallbladder dysfunction, jaundice, hepatomegaly, biliary insufficiency, gall stones, chronic skin conditions CI: normal things for bitters
39
Cineraria maritima - use? - contraindicated?
Dusty Miller leaf **Asteraceae family** indications: cataracts (topical) *I have to SEE to go to the CINE MA* AEs: hepato-veno-occlusive disease, hepatic failure, death CI: internal use, broken skin, pregnancy, lactation, aster family
40
Cinnamonum zeylanicum - which bug does it work against? - pregnancy?
Cinnamon oil from bark and leaf astringent, carminative, antimicrobial (H pylori), vasodilating, diaphoretic, antispasmodic indicated: loss of appetite, nausea, vomiting, dyspepsia AEs: GI irritant, N/V contraindicated: pregnancy, allergy, ulcers, acid reflux, *prolonged use could be toxic
41
Coleus forskohlii - contains what? - effects on the heart? lunggs? - contraindicated?
Coleus root * diterpene glycosides - adenylate cyclase activator, positive ionotropic (contractility), vasodilator, hypotensive, bronchodilator, anti-inflammatory, hypoglycemic, antihistamine, anti-plt indicated: asthma, dilated cardiomyopathy, HTN, allergies, glaucoma, hypothyroidism, obesity AEs: gi stimulation and nausea contraindicated: active peptic ulcers, pregnancy, lactation, children interacts with: cardiac glycosides (digoxin, convallaria, digitalis, leonurus), anticoags, insulin and hypoglycemic drugs, antihistamines, levothyroxine, increase bleeds with NSAIDs, antagonize PPIs
42
Commiphora mukul - main use? - interacts with what drug?
Indian bdellium gum/resin - hypolipidemic: increases hepatic binding sites for LDL, inhibits chol synthesis, decreases TGs, increases fecal excretion of bile acids and chol - anti-inflammatory: decreases pain of OA after 1 month indications: elevated LDL, HLD, inflammations (OA), nodulocystic acne contraindicated: IBD interactions: induce CYP450, decrease bioavailability of propranolol
43
Commiphora myrrha (molmol) - uses? - interacts w what pharm?
Myrrh resin from bark - antimicrobial, antioxidant, anti-inflammatory, expectorant, antitussive indicated: topical mouth and pharynx inflammation. internal cough expectorant contraindicated: pregnancy and lactation interacts: insulin and hypoglycemics
44
Convallaria majalis - contains? does what to the heart? - how do you treat an OD? - contraindicated? - interactions?
lily of the valley flower tips and rhizome **low dose herb** * glycosides - positive ionotropic (contractility), negative chronotropic (rate), negative dromotropic (conduction), positive bathmotropic (excitability) - natiuretic, diuretic - dose-dependent venoconstrictive indicated: arrythmia, cardiac insufficiency, hypotension AEs: nausea, vomiting, headache, death *treat with atropine - monitor K/glc/insulin* contraindications: digitalis and other cardiac glycosides (convallaria, digitalis, leonurus) interactions: hypokalemic drugs/diuretics, corticosteroids. anti-arrhythmics, pseudoephedrine, glycyrrhiza, calcium > will promote arrhythmia, potentiates BBs
45
``` Cordyseps sinensis - made from? indicated for? - contraindicated in? at toxic doses? - potentiates? ```
Caterpillar fungus -bronchodilator, antibiotic, anti-cancer indicated: acute infection, anemia, BM protection, fatigue, asthma, impotence, chronic cough, debility at toxic doses: *constipation, abd distention, irregular menstruation, amenorrhea potentiates Epinephrine
46
Corydalis ambigua - contains what? - used in? - contraindicated?
Corydalis root *isoquinolone alkaloids powerful analgesic, hypnotic, sedative, spasmolytic, tranquilizing, hallucinogenic. suppresses CNS, reduces BP, decreases GI motility indicated: severe nerve damage, emotional disturbances and tremors, high blood pressure, small intestine spasms, dysmenorrhea AEs: decreased menstrual flow, headaches, fatigue overdose: clonic spasms with musculature tremor contraindicated: pregnancy, breastfeeding
47
Crataegus oxyacantha (laevigata) - contains what? - similar to what drug class? - effects on heart? - drug interactions?
Hawthorn berries, flower, leaf - cardiac tonic: procyanidins and flavonoids increase coronary blood flow via vasodilation and red in peripheral resistance, positive ionotrope and chronotrope, *similar to class III antiarrhythmics*, lowers LDL - heart nutritive - hypotensive - anti-inflammatory: flavonoids decrease capillary fragility, prevent collagen destruction of joints indicated: CHF, arrhythmias, valvular murmurs, cap fragility, HTN interacts: antiplatelets increase bleed risk, may enhance glycoside drug/herbs, avoid with antiarrhthymics, increased side effects of BBs
48
Curcuma longa - actions? - indications? - contraindicated?
Turmeric rhizome - hepatic, anti-neoplastic, anti-inflammatory, immune modulator, antibacterial, antiplatelet Indicated for: reduction of pain and inflammation associated with OA, inflammatory conditions (IBD), gallstone prevention, jaundice, hepatitis, UBS, protection of NSAID induced ulcers, cancer, OA, RA, inflammation, asthma, skin, prevention of strokes and MIs AEs: stomach stuff CI: biliary obstruction, hyperchlorhydria, pregnancy interacts: warfarin
49
Cynara scolymus | - indications? actions?
Artichoke **Asteraceae family** - bitter, hypolipidemia indicated: dyslipidemia, poor digestion contraindicated in bitter CIs
50
Datura stramonium - which part of the plant is poisonous? - what does it contain? who is it similar to? - indicated for? - contraindicated? - drug interactions?
Jimson weed dried leaves *flowers are poisonous, but fragrant* **low dose herb** * contains tropane alkaloids (daturine, atropine, hyoscine, scopolamine* - these are anticholinergic and parasympatholytic - sedative, antispasmodic indications (folk medicine, we dont use it): asthma, convulsive cough, pertussis, bronchitis, influenza, severe catarrh, expectorant AEs: same as belladonna contraindicated: glaucoma, pregnancy, with anticholinergic or TCAs interacts: potentiates anticholinergic drugs - atropine, bupropion, dextromethorphan, dicyclomine, diphenhydramine, tiotropium bromide, tolterodine AND TCAs
51
Digitalis purpurea | - contains what? effects on heart?
foxglove leaf **low dose herb** * cardiac glycosides* positive ionotrope, negative chronotrope - cardiac stimulant, diuretic, emetic at high doses indicated: CHF, atrial arrhythmias AEs: *narrow therapeutic range*, GI sxs, yellow or green halo around objects contraindicated: 1/2 degree AV block, severe carditis, angina, arrhythmias, bradycardia. cardiac hypertrophy, aortic stenosis, kidney failure, hypokalemia/calcemia, hypercalcemia, pregnancy, lactation interactions: hypokalemic drugs/diuretics, corticosteroids. anti-arrhythmics, pseudoephedrine, glycyrrhiza, calcium > will promote arrhythmia, potentiates BBs
52
Dioscorea villosa - actions? - indications? - contraindicated in ?
Wild Yam root - spasmolytic, antirheumatic, anti-inflammatory, diuretic, diaphoretic, hepatic, cholagogue indicated: dysmenorrhea, endometriosis, PMS< threatened miscarriage, premature labor, smooth muscle spasm, colic, myalgia, neuralgia, OA RA acute rheumatism CI: biliary obstruction, cholecystitis, biliary cancer, pancreatic cancer, hepatitis, cirrhosis, pregnancy in high doses
53
Echinacea angustifolia, pallida, and purpurea - actions? - indications and contraindications? - children? - dont use with what drugs?
Purple cone flower root leaf and flower **asteraceae family** Adaptogen, immune modulator, immune stimulant, anti-inflammatory, antimicrobial/bacterial/viral, stimulates phagocytosis and activates macrophages, vulnerary and alterative indicated: influenza, URTI, pharyngitis, tonsillitis, staph skin, vaginitis, mastitis, wounds, skin ulcers, acne, chronic skin disease, cancer, mycobacterial infection contraindicated: aster family, TB, MS, AIDS, HIV, auto-immune disease, possible long term use * safe for use in children* interactions: immune suppression therapy
54
Eleutherococcus senticosus - actions? - indicated? - contraindicated?
Siberian ginseng root - Adaptogen, immune modulating, adrenal support indicated: pharyngitis, tonsillitis, infection, fatigue, hypoadrenocorticism, lack of stamina, tendency to infection contraindicated in autoimmune conditions, hypertension, acute infections, and long term use interacts with immune suppression therapy
55
Ephedra sinica - actions? - indications? - side effects? - contraindicated? - interactions?
Ephedra, Ma Huang stem **low dose herb** adrenergic agonist, bronchodilator, antitussive, anti-allergic, decongestant, anti-secretory, vasoconstrictor, hypertensive, diaphoretic, diuretic indicated: bronchitis, asthma whooping cough, sinusitis, allergies, weight loss AEs: agitation, alertness, MI, cerebral vasculitis, stroke OD: sympathomimetic contraindicated: HTN, hyperthyroid, DM, BPH, glaucoma, CAD, anorexia, pregnancy, lactation, long term interacts: potentiates sympathomimetics, caffeine, dextroamphetamine, methylphenidate, MAOIs antagonizes a and B blockers, TCAs, and increases clearance of dexamethasone
56
Equisetum arvense - used for? - contraindicataed? - interactions?
Horsetail aerial parts diuretic, astringent - decreases uric acid content in the blood by increasing clearance rate indicated: UTI, kidney and bladder stones, nocturnal enuresis CI: edema d.t impaired heart or kidney function, hypokalemia, and coagulation disorders interactions: hypokalemic drugs, warfarin
57
Eschscholzia californica - who do we use in? - contraindicated? - drug interactions?
California poppy dried aerial perts - nervine, hypnotic, anti-spasmodic, anodyne indicated: sedative and hypnotic for children, nerve pain (not joint pain), anxiety, insomnia AEs: addictive contraindicated: pregnancy, lactation interactions: could potentiate MAOIs and SSRIs
58
Eucalyptus globulus - topical? internal uses? - avoid with?
Eucalyptus lead - antimicrobial, counter irritant, antispasmodic, expectorant, antiperiodic topical: aching joints and muscles, add to bath water, insect repellant, wounds, burns, ulcers internal: URTI, pharyngitis, tonsillitis, nasal stuffiness CI: hypotension, kidney function impaired *infants - as it could produce a laryngeal spasms and respiratory arrest interacts: hypoglycemic agents
59
Eupatorium perfoliatum - most indicated for? - contraindicated?
Boneset aerial parts **asteraceae family** respiratory, diaphoretic, immune and digestive bitter stimulant, affinity for the respiratory and GI systems, urolithiasis, anti-catarrhal, asntispasmodic indicated: **influenza**, aches and pain, fever,
60
Eupatorium purpureum - what is it? - class? - indications?
Grave root, Joe pye weed Root **asteraceae family** - anti-lithic, diuretic indicated: urolithiasis, dysuria, hematuria from prostatitis, gout
61
``` Euphrasia officinalis (stricta) - used for? ```
Eyebright aerial parts - anti-inflammatory, anti0catarrhal, astringent, vasoconstrictor indicated: ophthalmitis, allergic rhinitis and conjunctivitis, sinusitis, blepharitis, hordeolum, eye trauma
62
Foeniculum vulgare | - contraindicated in which allergy?
Fennel seeds carminative, spasmolytic, anti-inflammatory, phytoestrogen, galactogogue indicated: flatulence, colic, stimulates digestion and appetite, calming effect for bronchitis, cough, infant colic, dyspepsia, maldigestion, IBS, catarrh of URT AEs: **celery allergy - although very rare*, CNS toxicity in high doses contraindicated: pregnancy, < 2 yo, prolonged use
63
Fucus vesiculosis - contains? - treatment of? - contraindicated in? - decreases absorption of? due to ? content?
Bladderwrack, kelp - iodine, nutritive, anti-obesity, antirheumatic indicated for: RA, iodine-deficient hypothyroidism, goiter, obesity AEs: could aggravate hyperthyroidism, long term ingestion could decrease iron absorption due to polysaccharide fucoidan, could be contaminated with heavy metals, acne contraindicated: hyperthyroidism, pregnancy, lactation interacts: anticoags, antiplatelet and thrombolytic agents
64
Galium aparine - external? internal indications? - avoid what with it?
Cleavers aerial parts - alterative and lymphatic, diuretic and antinodular indications: topical for acne and chronic skin diseases, ulcers, festering glands, lumps in breast and skin rashes. internal for acute lower urinary tract infections, urolithiasis, lymphadenitis diuretic (avoid with Lithium)
65
Ganoderma lucidum - what is it? - actions? - weird AE and allieviated when coadministered with?
Reishi mushroom - Adaptogen, immune activation, nervine, hypotensive, antiallergy, antibacterial, anticancer, antioxidant, antithrombotic AEs: darkened stool, diarrhea *allieviated when coadministered with Vit C* contraindicated: organ transplants and autoimmune interacts: immunosuppressive, sedatives, anticoags, and statins
66
Gelsemium sempervirens - indicated? - contraindicated? - drug interaction?
Yellow jasmine dried rhizome **low dose herb** contains indole alkaloids and hydroxycoumarins - anticholinesterase, vasodilation, hypotensive, bronchodilation, affects smooth muscles, analgesic, mydriasis - it stimulates, then depresses neural function > antispasmodic, cardio-sedative indication:ovarian cyst pain, topical on the os to induce labor, insomnia, fever, nervous unrest, headache, convulsions, neuralgia, dysmenorrhea, asthma AEs: double vision, dry mouth, vomiting > loss of speech, pupil enlargement, trembling, paralysis, cyanosis, coma, death contraindicated: hypotension, MG, pregnancy, resp or cardiac disease could potentiate aspirin
67
Gentiana lutea | - actions?
Gentian rhizome and root bitter, cholagogue, hepatotonic, sialogogue, antimicrobial, emmenagogue indicated: dyspepsia, loss of appetite, flatulence, stimulates bile secretion, increases gut motility AEs: excess stomach acid and nausea CI: diarrhea, ulcers interacts: PPIs
68
Geranium maculatum - contains which constituent? - indications?
American Cranesbill rhizome and leaves *tannins - astringent, styptic, venotonic indicated for: diarrhea and bleeding, hemorrhoids, gastritis, varicose veins, ulcers, menorrhagia, metrorrhagia, dysmenorrhea **only to be used short term**
69
Ginkgo biloba - actions? - indications? - contraindications?
ginkgo leaf - anti-neoplastic, anti-inflammatory, vasodilator, antioxidant, inflammation modulator, bronchodilator - nootropic: inhibits cyclic nucleotide phosphodiesterases (caffeine), increases neuronal activity and memory - anti-platelet: inhibits PAF (platelet activating factor) to decrease plt agg and degranulation indicated: atherosclerosis, intermittent claudication, impotence, post-ischemic stroke, phlebitis, cerebrovascular insufficiency (depression, dementia, poor memory) contraindicated: intracranial bleed, severe bleeding interactions: blood thinners, as it inhibits PAF
70
Glycyrrhiza glabra - use against what bug? - relationship to adrenals? - adverse effects? - contraindicated in? - interactions?
Licorice root - Adaptogen, phytoestrogen, hepatoprotective, expectorant, anti-inflammatory, demulcent, antiviral, antibacterial *hy pylori* Indicated in: stress, fatigue, may be helpful in HIV infection, cough, bronchitis, catarrh of URT, ulcers, sore throat, gastritis, appendicitis, constipation, to increase milk production, adrenocorticoid insuff, insomnia AEs: can lead to pseudoaldosteronism, rhabdomyolysis, hypokalemia, reduces thyroid activity **contraindicated in HTN as it can increase corticosteroids and HTN**, hyperaldosteronism, cirrhosis, hepatitis, CHF, diabetes, pregnancy, long term use interacts: cardiac glycoside drugs * protects mucosal damage from ASA*
71
Grindelia robusta - indicated? - important AE?
Gumweed leaves and flower **asteraceae family** inflammation modulator, respiratory stimulant**, relaxing expectorant, antispasmodic, cardiac tonic indicated: asthma, dry cough*, URTI, bronchitis, cough w arrhythmia/cardiac cough AEs: *selenium overdose, bradycaria
72
Gymnema sylvestre - indications? - contraindicated in? - interacts with?
Gymnema leaf - hypolipidemic, anti-obesity indicated: DM, metabolic syndrome, weight loss, hypercholesterolemia AEs: aggravates reflux contraindicated: GERD interactions: will decrease insulin requirement, potentiates hypoglycemic drugs, could potentiate atorvastatin
73
Hamamelis virginiana - contains? - used? - high doses can cause?
Witch hazel twig and leaf *contains tannins - astringent*, anti-inflammatory, local hemostatic effects indications: *external use* all cases of bleeding, hemorrhoids, varicose veins, bruises, inflammation. can control diarrhea and dysentery, sore throat, tonsillitis, acute catarrh. can use internally, but use common sense. AEs: high doses can increase risk of esophageal and liver cancer (drinking teas 15-20 cups/day)
74
Harpagophytum procumbens - actions? - indications? - interactions with pharm?
Devil's claw rhizome antiinflammatory, antirheumatic, anodyne, analgesic, bitter digestive stimulant, hepatic indicated: arthritis, tendonitis, dyspepsia, lack of appetite, liver and GB complaints interactions: ulcers, drugs not to be used with bitters, decreases the need for NSAIDs and other analgesics
75
Humulus lupulus - actions - contraindicated
Hops whole dried flowers - humulone can inhibit gram + and - bacteria, some fungi and yeast. other constituent has a sedative effects - nervine and sedative, phytoestrogen activity, digestive bitter, cholagogue, mild laxative indicated for: sleeplessness from worry, anxiety, nervousness, stimulate appetite and increase gastric juice secretion AEs: nausea, headache contraindications: depression, pregnancy interacts: barbiturates
76
Hydrangea arborescens - indicated? actions? - at high doses > ?
Seven barks rhizome - diuretic, anti-lithic, antimicrobial used in UTIs, prostatitis, BPH, urolithiasis, dysuria, urethritis, acute nephritis, *acute pyelonephritis AEs: high doses can cause vertigo and feelings of constriction in the chest
77
Hydrastis canadensis - actions, indications, AEs - drug interactions, vitamin interaction.
Golden seal rhizome - hepatic, bitter, choleretic, anti-catarrhal, antimicrobial, immune modulator, antineoplastic, spasmolytic, astringent, "king of the mucous membranes" indicated: acute cystitis, poor digestion, catarrh on mucous membranes, URTIs, candidiasis, vaginitis, mastitis, gastroenteritis, H pylori, intestinal parasites, cholera, staph skin infection AEs: dysbiosis, berberine displaces BR from albumin, GI., dyspnea, bradycardia, spasms, delirium, hallucinations CI: bitter digestive CIs, long term high doses interacts: PPIs, hypoglycemic drugs, barbiturates, *reduces absorption of B vitamins, paclitaxel
78
Hyoscyamus niger - what does it contain? who is it similar to? - death by? - interactions?
Henbane leaves **low dose herb** * contains tropane alkaloids* - parasympatholytic or anticholinergic effects - sedative, hypnotic, antispasmodic indications: dyspepsia, spasms, cough, nervous irritability, insomnia, delirium AEs: same as bella donna and datura, death by asphyxiation contraindicated: tachy arrhythmias, prostatic adenoma, angle-closure glaucoma, megacolon interactions: anticholinergic drugs and amantidine
79
Hypericum perforatum - comparable to which classes? - indicated to help wean people off? - effect on what labs? - contraindicated when? - CYP?
St. John's Wort buds - comparable to TCAs and SSRIs, dose is dependent on the inhibition of re-uptake for NE and 5-HTP > may increase serotonin, lower cortisol and act on GABA-R - antibacterial, anti-viral - anti-inflammatory, suppresses leukocyte infiltration on wounds - astringent, vulnerary, nervine indicated: depression, anxiety, skin inflammation wounds, burns, blunt injuries, wean people off MAOIs AEs: high doses with exposure to UV light causes rash, alopecia, diarrhea, indigestion, fatigue, depression, elevated liver enzymes contraindicated: suicidal ideation, high doses in pregnancy - useful in HIV infection, but avoided in patients who take antiretroviral drug therapy as it changes the metabolism and could lead to underexposure and treatment failure - induces CYP450 3A4: decreases effectiveness of warfarin - contraindicated in people taking OCPs, benzos, TCAs, SSRIs, theophylline, cyclosporine, digoxin, warfarin
80
Inula helenium - kind of cough? - contraindicated?
Elecampagne rhizome **asteraceae family** - respiratory expectorant, antiseptic, diaphoretic, pulmonary tonic and demulcent (mucilage), antimicrobial and antihelminthic, antibiotic, antitussive, anticatarrhal indicated: asthma, COPD, wet cough and dry cough, spasmodic cough, URTI, bronchitis, intestinal parasites CI: pregnancy and allergy
81
Iris versicolor | - indicated?
Blue flag root **low dose herb** - lymphatic alterative, cholagogue indications: skin disease - eczema and psoriasis *liver detox*, indicated for an enlarged thyroid or lymphatic enlargement that is soft, without pain
82
Juglans nigra - treats? - side effect? - pregnancy?
Black Walnut bark, leaves, rind antihelminthic, antiparasitic, astringent, antimicrobial, hypolipidemic indicated: parasites and worms, chronic constipation, dysentery, hemorrhoids, high cholesterol AEs: N/V/diarrhea, *carcinogenic, mutagenic CI: pregnancy, long-term use
83
Juniperus communis - indicated for? - AEs? constiuent responsible? - contraindicated?
Juniper berry - diuretic, bacteriostatic, antiseptic, urinary sedative, digestive stimulant bitter indicated: hypochlorhydria, dydpepsia, maldigestion, biliary insufficiency, dyskinesia, anorexia, atonic constipation, gas *lower UTI and renal atonia* AEs: has thujone: emmenagogue, abortifacient, convulsions CI: pregnancy, breastfeeding, inflammatory renal dz
84
Larrea tridentata - topical for? internal for? - avoid in which pt populations?
Chaparral aerial parts - infection, anti-neoplastic, antimicrobial, antiallergic, antispasmodic, expectorant topical: herpes, poultice for resp problems, skin complaints internal: ; allergic rhinitis, cancer, infections d/t bacteria, yeast, larvae, viruses, and parasites AEs: has a strong tae, nausea, vomiting, jaundice, hepatotoxicity, contact dermatitis contraindicated: **NOT safe for use in children, can be hepatotoxic in large doses**, high doses and long term use interacts: hepatotoxic drugs and CYP450
85
Leonurus cardiaca - contains what? - indications?
Motherwort whole plant * cardiac glycosides - hypotensive, inhibits myocardial cell firing, diuretic, antispasmodic (uterus and blood vessels), sedative (but takes months), improves mesenteric circulation and coronary perfusion indicated: nervousness, irritable, restless, menopause, hyperthyroidism, palpitations/anxiety, reduced coronary perfusion contraindicated: pregnancy
86
``` Leptandra virginica (Veronicastrum virginicum) - actions? indications? CIs? ```
Black root - hepatic, bitter digestive and hepatotonic, diaphoretic indicated: poor digestion, hepatitis, liver congestion, cholecystitis CI: normal bitter digestive
87
Ligusticum porteri - actions? - indications?
Osha root - antimicrobial, antiviral, antiseptic, stimulant, diaphoretic, carminative, (similar to lomatium) indication: upper and lower respiratory tract infection, viral infections, induces sweating dont use in pregnancy
88
Ligustrum lucidum - when is it used? - adjunct to chemo why?
Chinese privet - Adaptogen, immune modulating, anti-inflammatory, hypolipidemic indicated: infections, hypercholesterolemia, hepatitis, adjunct to chemo to protect BM interacts: could antagonize immune suppression therapy
89
Linum usitatissimum - richest source of? - indicated?
Flax seed *richest known source of omega 3s and lignans* demulcent, laxative, emollient, antitussive, anodyne, anti-inflammatory, anti-thrombotic, antineoplastic/antimycotic/antioxidant/antiestestrogenic (lignans) indicated: constipation, GI irritation, nutritive, hormone balance, breast CA contraindicated: ileus, stricture, acute inflammation interactions: could delay absorption of other drugs
90
Lobelia inflata - how does it act? - used in? not used in?
Indian tobacco, Pukeweed aerial parts **low dose herb** * initially CNS stimulation > respiratory depression (similar to nicotine in that it has peripheral and central nervous system effects) - parturifacient when applied to the os. stimulating expectorant, lung tonic, spasmolytic, nervine, diuretic cathartic indicated: used in wet/spasmodic cough, acute asthma, URTI, dyspnea, smooth muscle spasm. topical for rigid os preventing labor AEs:tachycardia, diaphoresis, resp dep, unconsciousness, death *will vomit first* contraindicated in dry cough (same as sanguinaria, aspidosperma), cardiac hypertrophy, HTN, heart block, weak, pregnancy, lactation, infants, high doses
91
Lomatium dissectum - indications? - side effect?
Indian balsam root - antiviral, bacterial and fungicidal, immune stimulating, antitussive, expectorant indicated: viral resp infection, cough, cold, bronchitis, influenza, pneumonia, TB side effects: photosensitization *safe for use in children, but can cause a full body pruritic rash in rare cases, looks like measles* contraindicated: pregnancy
92
Lycopus virginicus - lowers 3 hormones? - dont give with?
Bugleweed aerial perts **low dose herb** - antigonadotropic (lower PRL), antithyrotropic (inhibits peripheral de-iodination of T4 > T3 in the liver), will normalize an overactive thyroid, inhibits TSH which then lowers T4 production, corrects heart beat irregularity, cardiac sedative, nervine, calms nervous cough indications: a mild overactive thyroid, hyperthyroidism, nervousness, insomnia, PMS contraindicated: hypothyroidism, goiter, dont give with thyroid hormone, infertility, pregnancy interactions: hypothyroid meds
93
Matricaria recutita (chamomilla) - helps prevent? - contraindicated? - interacts with which drugs?
Chamomile flower **Asteraceae family** carminative, mildly bitter digestive, sedative, anti-inflammatory, anodyne, antimicrobial, anti-allergy, vulnerary, anti-emetic, spasmolytic, diaphoretic, hypnotic, anxiolytic, nervine indicated: IBD, digestion complaints, decrease stomach ulcer healing time, helps prevent formation of ulcers d/t ASA/EtOH/stress, relax smooth muscle, stimulate B-lymphocyte and macrophage activity, atopic derm, skin ulcers, wounds, N/V in pregnancy, amenorrhea, dysmenorrhea, leukorrhea, infant colic, gas, gastritis, smooth muscle spasms, fever, periodontal disease, gingivitis, insomnia, anxiety, pharyngitis, tonsillitis, sinusitis AEs: sensitivity to chamomile, pregnancy? interacts: can potentiate sedatives - antihistamines, barbiturates, benzos, opiates, hydrocodone, morphine, trazodone, zolpidem
94
Medicago sativa - actions? - indications? - be wary if spoiled, could contain? - contraindicated in 3 things? - interacts with what 4 drugs?
Alfalfa whole plant or seeds - phytoestrogen, hepatoprotective, antioxidant, cholesterol lowering (saponins) indicated: endometriosis, hyperestrogen, infertility, menopause AEs: if spoiled, might contain E coli, bacillus cereus, salmonella contraindicated: gout, SLE, pregnancy interacts: hypoglycemic drugs, anticoags, HRT, CYP450
95
Melaleuca alternifolia - what bugs can it kill? - indications?
Tea tree leaves - antifungal, microbial and antiseptic, immune stimulating: causes autolysis of bacteria *staph aureus, E coli* topical: dermatophytosis, onychomycosis, acne, thrush, vaginitis, staph skin infections, wounds, insect bites can have a burning sensation dont use over large areas of broken skin or internally
96
Melissa officinalis | - indicated?
Lemon balm leaves and oil carminative, anti-spasmodic, and sedative, antiviral indicated for IBS from anxiety and depression, relieves colic, cardiac problems related to anxiety/restlessness, also used as a topical for skin irritations *safe for use in children* (Lemon balm, leonurus, and lycopus for hyperthyroidism)
97
Mentha piperita - avoid in what disease? - pregnancy? - pharm interaction?
Peppermint leaves spasmolytic, antiviral, antimicrobial, diuretic, carminative, sedative, cooling to skin indicated for: nausea, flatulence, abd discomfort, and diarrhea, cholelithiasis, infant colic, IBS, IBD, nausea. vomiting. topical - myalgia, OA, RA, headaches, strains, sprains AEs: avoid with G6PD def, prolonged use as an inhalant contraindications: pregnancy (emmenagogue), GERD, biliary occlusion, GB inflammation, severe liver damage interacts: CCBs
98
Mitchella repens - actions? - indicated for? - contraindicated?
Partridge berry aerial parts - parturifacient, uterine tonic, emmenagogue, alterative, astringent, diuretic indicated: dysmenorrhea, infertility, leiomyoma, menorrhagia, poor uterine tone, preparing for childbirth contraindicated in early pregnancy
99
Momordica charantia - indicated for? - contraindicated?
Bitter melon leaves, fruits, seeds, and seed oil hypoglycemic and hypolipidemic, emmenagogue indicated for: late-onset diabetes, non-insulin dependent diabetes AEs: possible food intolerance contraindicated: pregnancy d/t emmenagogue/abortifacient activity, hypoglycemia, lactation interacts: antidiabetic agents could increase risk of hypoglycemia, anticholesterol agents
100
Olea europaea | - contraindications?
olive dried leaves and fresh branches w flower fruit: lecithin and bitter, leaf: bitter glycoside - nutritive, emollient, demulcent leaf: increases phagocytosis, bitter, antibacterial and antiviral, antiviral, antipyretic, antifungal, hypotensive and hypoglycemic olive leaf extract (oil): calcium elenolate kills viruses and bacteria, oleuropein inhibits LDL oxidation and antioxidant, increases coronary blood flow, emollient, cholagogue, mild laxative, hypotensive, hypocholesterolemic indications: fruit oil: externally for dry skin, cradle cap, internally to decrease heart disease risk leaf: HTN leaf extract: malaria, chills, diarrhea, severe viral infection, fevers and chills contraindications: large gallstones cautions: take after meals as the extract is a GI irritant could potentiate warfarin and hypoglycemic drugs
101
Panax ginseng/quinquefolius - which is yin/yang? - indications? - weird AE? - contraindicated? - interactions?
Korean/American Ginseng - Adaptogen, vulnerary, anti-tumor, hypoglycemic, phytoestrogen, *ginseng - yang tonic, quin - yin tonic* indicated: may be helpful in HIV infection, pharyngitis, tonsillitis, cancer, infection, auto-immune disease, male infertility, fatigue, stress, diabetes, hyperestrogenism, hypoestrogenism, opiate withdrawal AEs: mastalgia, PMB, *ginseng abuse syndrome: euphoria, diarrhea, nervousness, insomnia, HTN, skin eruptions* contraindicated: HTN, hemorrhage, asthma, anxiety, depression, psoriasis, long term use, high doses, pregnancy could potentiate MAOIs, morphine, insulin, hypoglycemic drugs, immune drugs. antagonize warfarin, immune suppression therapy
102
Passiflora incarnata - effect on heart? - indications? - contraindicated? - interactions?
Passion flower whole plant - glycosides with hypotensive effects, stimulates respiration - nervine, sedative, antispasmodic indicated: insomnia, nervousness, restlessness, spasms, convulsions, nervous palpitations and tachycardia contraindicated: pregnancy (uterine stimulant) interacts: SSRIs, MAOIs, sedatives
103
Pausinystalia yohimbe - action! - treats? - AEs? - contraindicated? - interacts with what drugs?
Yohimbe bark **low dose herb** - aphrodisiac, *a2 adrenergic blocker, serotonin antagonist: stimulates erection and salivation, prolongs and strengthens erection, cerebral stimulant indicated: impotence, ED, depression, narcolepsy AEs: nausea, salivation, dizziness, nervousness, insomnia, anxiety, mania, mydriasis, HTN, edema fatigue, paralysis, HAs, diuresis, palpitations, tachypnea, resp paralysis, cardiac paralysis, death contraindicated: schizophrenia, panic attacks, PTSD, CAD, severe edema, HTN, angina, peptic ulcer, renal disease, liver disease, prostatitis, pregnancy, lactation interacts: a-adrenergic blockers, TCAs, MAOIs, sympathomimetics, clonidine, atropine
104
Phytolacca americana - indicated? - large doses can cause? - contraindicated?
Poke Root **low dose herb** - alterative, lymphatic, antiviral, saponins have an emetic effect indicated: cleansing of lymph glands, URTI (catarrh, tonsillitis, laryngitis, swollen glands, mumps), topical for mastitis AEs: large doses - emetic and purgative CI: pregnancy, long term in lactation and high doses
105
Piper methysticum - inhibits which enzyme? - indicated for what kinds of neuralgia? - toxic to which organ? other AEs? - pregnancy? breastfeeding? - drug interactions?
kava kava rhizome **low dose herb** - analgesic (inhibits COX2), antinociceptive, inhibits the limbic system (sedative, anxiolytic) and sodium ion currents (skeletal muscle relaxant, antispasmodic) indicated for anxiety, restlessness, tension, agitation, neuralgia (facial, trigeminal, toothache) *can help with benzo withdrawal symptoms* AEs: hepatotoxicity, addictive, exfoliative dermatitis, ulcers, vomiting, LOC contraindicated in hx of liver disease, depression as it increases suicide danger, enters breast milk and should not be used in pregnancy interacts: antipsychotics and benzos
106
Piscidia erythrina (piscipula) - indications - AEs? - contraindicated? - interactions?
Jamaican dogwood bark **low dose herb** - sedative, analgesic, anodyne indicated: anxiety, fear, daytime sedative, myalgia, spasms AEs: in high doses - N/V, salivation, sweating, hyporeflexia, bradycardia, mydriasis, depressed consciousness, convulsion, respiratory depression, heart failure, death contraindicated: pregnancy interacts: sedatives
107
Plantago major | - used for?
Plantain leaf and aerial parts - demulcent and vulnerary, astringent and antimicrobial for dermatitis, wounds and ulcerations - expectorant: ideal for coughs and mild bronchitis, - astringent: diarrhea, hemorrhoids, cystitis
108
Podophyllum peltatum - indications? - die by?
American mandrake, mayapple rhizome and resin **not used anymore** **low dose herb** purgative, antitumor indicated: warts, constipation, cancer AEs: should not be taken internally: can aggravate abd pain, bloody watery diarrhea, vomiting bile, collapse and death via resp failure contraindicated: pregnancy, gallstones
109
Prunus (Pygeum) africana(um) - action? - indication? - contraindicated? - what pharm and herbs does it interact with?
dried bark - prostatic tonic, 5aRI, anti-inflammatory indicated: BPH, chronic prostatits, low prostatic secretions AEs: possible GI irritation, nausea, stomach pain contraindicated: pregnancy, lactation interacts: 5-alpha reductase inhibitors (finasteride, pygeum, serenoa)
110
Prunus sertotina | - used in what kind of cough?
Wild black cherry, choke cherry inner bark - relaxing expectorant, astringent, antitussive, mild sedative indication:irritating/spasmodic cough, bronchitis and whooping cough AEs: large doses are toxic contraindicated: pregnancy
111
Pulsatilla vulgaris - indications? - AEs?
Pulsatilla, Wind Flower, Pasque Flower, fresh whole plant - antipyretic, strong local irritant to mucus membrane and skin, nervine, sedative, emmenagogue indicated: pain, amenorrhea, dysmenorrhea, endometriosis, PMS, leukorrhea, insomnia, nervousness, headache, URTI, asthma, indigestion, IBS AEs: extended contact with plant > blisters, unsafe orally contraindicated: pregnancy
112
Quercus rubra - contains which constituent? - indicated in what 2 things topically? 1 thing internally? - dont use if someone has this kind of anemia?
Red Oak bark * tannins = astringent, styptic, anti-inflammatory, antiseptic topical: varicosities, anal fissure, wounds, burns, strains, sprains **weeping eczema**, *hemorrhoids* douche: leukorrhea, vaginal prolapse, PP uterine bleeding internal: **diarrhea*, dysentery, rectal bleed, IBD, ulcers AEs: IDA*, malabsorption occurs with long time use contraindicated: HF, constipation, IDA interactions: tannins reduce drug absorption
113
Rauwolfia serpentina - contains what? has what effect on heart? - contraindicated?
snake root **low dose herb** * indole alkaloid reserpine* - antihypertensive alkaloids: releases noradrenaline and inhibits its resorption > lowers catecholamines > hypotensive effect - antiarrhythmic alkaloids ajmaline indications: HTN, nervousness, insomnia AEs: nasal congestion, depression, tiredness, ED contraindicated: depression, PD, ulceration, pheochromocytoma, pregnancy, lactation interacts: increases alcohol impairment, increases effect of neuroleptics and barbituates, severe bradycardia with digitalis glycosides, herb effect is reduced w/ levodopa, increase in extra pyramidal motor sxs w sympathomimetics
114
Rhamnus frangula and purshiana - how does it work as a laxative? - indications? - weird AE? - contraindications? - interactions?
Frangula and Cascara sagrada dried bark laxative, cathartic, emetic, bitter *induces active secretion of electrolytes and water into the lumen and inhibits the absorption of water and electrolytes by stimulating contractions indicated: constipation AEs: harmless red urine and feces, pseudomelanosis coli contraindicated: pregnancy, breastfeeding, obstruction, children < 12, for more than 1-2 weeks, bloody diarrhea interacts: hypoK drugs
115
Rhodiola rosea - indications - do not use with which patients?
Rhodiola root - adaptogen, antistress, antioxidant, antineoplastic, cardioprotective indications: increase physical endurance, work, productivity, longevity, resistance to altitude sickness, fatigue, depression, anemia, impotence, GI ailments, infections, nervous system *most indicated for fatigue, exercise endurance, and general well-being* AEs: activating yet antidepressant effect - do not use in patients with bipolar, take early in the day to not interfere with sleep contraindications: manic interactions: could interact with stimulants
116
Ricinis communis - how does it work? - how many beans will kill someone
Castor oil from seeds **severely poisonous* laxative, purgative *ricinoleic acid > an anti-aborptive and secretogenic indicated: constipation, external for inflammatory skin disorders, furuncles, carbuncles, abscesses AEs: same as all cathartic laxatives. 12 beans can kill someone - death by hypovolemic shock - TX with IV diazepam and fluids avoid hypoK drugs
117
Rosmarinus officinalis - how is it used topical? internal? - at toxic doses > ? - pregnancy? - pharm interactions?
Rosemary oil from leaves antimicrobial, hypertensive, circ stimulant, antioxidant, carminative, circulation improvement when applied topically, nervine topical: myalgia, neuralgia, arthritis internal: dyspepsia, loss of appetite AEs: at toxic doses > coma, spasm, vomiting, death CI: pregnancy, epilepsy interacts: doxorubicin, vinblastine
118
Rubus idaeus - used in? - contraindicated? - contains?
Raspberry leaves and fruit - parturifacient (strengthens contractions, reduces hemorrhage during labor), uterine tonic, astringent, inflammation modulator indicated: prep for labor as it strengthens uterine tone, diarrhea, leukorrhea, aphthous ulcers, gingivitis, conjunctivitis contraindicated: early stages of pregnancy * contains tannins, vitamin C
119
Rumex crispus | - indications
Yellow Dock root regulator, alterative, hepatoprotective, laxative indicated: mild constipation, sluggish digestion, liver congestion, scurvy, blood cleansing, inflammatory and hormonal skin conditions - acne AEs: same as other cathartic laxatives contraindicated: GI irritation, kidney disease, oxalates interacts: hypoK drugs
120
Salix alba - used for? - adverse effects? - contraindicated in?
white willow bark - analgesic, anti-inflammatory, febrifuge, anti-rheumatic indicated: rheumatism, gout, fevers, aches, pains, menstrual pain, sweating, hot flashes AEs: *salicylism (N/V) from tannins, Gi irritation, tinnitus, lethargy, dizziness, cerebral edema, seizures contraindicated: children w flulike sxs **REYES SYNDROME**, salicylate sensitivity, G6PD def, pregnancy, lactation, long term use interacts: acetaminophen and NSAIDs, warfarin
121
Salvia officinalis - external and internal indications? - breast milk? - contains? contraindications?
Sage leaf antimicrobial, anti-secretory, astringent, anti-inflammatory, carminative indicated: inflammation of mouth throat and tonsils, internally as a mouthwash for gingivitis, glossitis, stomatitis, gargle for aphthous ulcer, laryngitis, pharyngitis, tonsillitis. a compress for wound healing internal: carminative, can *lessen production of breast milk AEs: thujone emmenagogue, abortifacient, convulsions contraindicated - large doses due to thujone, pregnancy (stimulates uterine contraction)
122
``` Sambucus nigra (and canadensis?) - how is the flower, leaf, and berry used differently? ```
elder berry flower: diaphoretic, anti-catarrhal, anti-spasmodic: *cold and influenza, *any catarrhal URTI leaf: diuretic, diaphoretic, expectorant, emollient, vulnerary: *topically for bruises, sprains, wounds berry: diaphoretic, diuretic, laxative, antirheumatic: *rheumatism * safe for use in children*
123
Sanguinaria canadensis - actions? - uses? - internal indication and contraindication? cough?
Bloodroot **low dose herb** - stimulating expectorant, escharotic, antimicrobial, cholagogue, sialogogue external: cervical dysplasia, BCC, SCC, tinea pedia, warts, nasal polyps oral rinse: gingivitis, periodontal disease, tickling cough, amenorrhea, hep A *stimulating expectorant used in wet cough to promote expectoration - but we dont use internally anymore - DEATH* Aes: oral leukoplakia with long term use contraindicated in dry cough (same as aspidosperma, lobelia), closed angle glaucoma, pregnancy, lactation, infants
124
Schisandra chinensis - actions? - indicated? - contraindicated? - interacts with? decreases harmful effects of? used in treatment of which med recovery?
Schisandra berries - Adaptogen and immune modulating, hepatoprotective, stimulant, sedative, expectorant, anti-tussive, sexual tonic indicated: chronic hepatitis, liver damage fatigue, physical stress debility, depression, insomnia, liver detox contraindicated in autoimmune conditions, epilepsy, severe HTN, intercranial pressure interacts:potentiates barbiturates, decreases acetaminophen toxicity, inhibits CYP 450, used for withdrawal from benzos and opiates
125
Scutellaria bicalensis - indicated for? - contraindicated?
Chinese skullcap root antioxidant, antiallergic, anti-inflammatory, antimicrobial, antirheumatic, anticancer indicated: Bi CLEANSE the SInuS *asthma, hay fever, dermatitis, acute infections* (different than lateriflora indications) AEs: hepatotoxicity, sedation, hypotension CI: early pregnancy interacts: warfarin, sedatives, barbiturates, benzos, opiates, trazodone, zolpidem
126
Scutellaria lateriflora - indications? - AEs?
skullcap aerial parts - anti-spasmodic and nervine, anticonvulsant, hypnotic, anxiolytic, anodyne indicated: *need to LAY on the FLORA*: insomnia, anxiety, pain, nervousness, headache, delirium, seizures, irregular arrhythmias, fasciculations* (different than bicalensis indications) AEs: tremors, hepatotoxic
127
Selenicereus (cactus) grandiflorus - similar to what other herb? - what drugs does it interact with?
night-blooming cactus flowers and stems **low dose herb** similar effects to digitalis (stimulation, vessel dilation) but also stimulates motor neurons of the spinal cord -sympathetic stimulant to the heart and kidneys, diuretic indicated: impaired heart function, rapid pulse with edema, mitral regurgitation, angina, palpitations, chest pain, dyspnea, arrhythmia, prostatitis, kidney congestion AEs: nausea, vomiting, arrhythmia, tachycardia, confusion, headache, GI distress, heart failure contraindicated: pregnancy, lactation, and high doses interactions: might potentiate MAOIs (phenelzine)
128
Serenoa repens - how does it act? - indications? - interacts with what pharms?
Saw palmetto fruit - prostatic tonic, 5aRI (anti-androgenic, antiestrogenic, anti-inflammatory: inhibits the binding of DHT to receptors > prevents accumulation of the steroid. inhibits conversion of T > DHT and DHT > androgens indicated: BPH, inflammation of urinary tract and bladder, nocturnal enuresis, libido AEs: pregnancy, BF contraindicated prior to surgery as it carries a risk of hemorrhage interacts: warfarin, 5aRI, hormone-like drugs, adrenergic drugs, iron *tannins
129
Silybum marianum - actions? - reduces AEs fo which 4 drugs?
Milk Thistle seeds **asteraceae family** hepatotropic, hepatorestorative, cholagogue, anti-inflammatory *silymarin: inhibits the entrance of toxins into liver, decreases production of free radicals in Kuppfer cells, inhibits LT formation (cirrhosis and fibrosis), increases GSH production indicated: dyspepsia, toxic liver damage, hepatic cirrhosis AEs: sweating, abd cramping, nausea, vomiting, diarrhea contraindicated: pregnancy interacts: protects against SEs of acetaminophen, cisplatin, cyclosporine, and MTX. potentiates doxorubicin
130
Smilax spp | - indications, actions?
Sarsaparilla root - alterative, antirheumatic, diaphoretic, anti-inflammatory, diuretic (steroidal saponins) indicated: GOUT, chronic dermatitis, psoriasis, fevers, arthritis, rheumatic complaints, reduction of pain and inflammation associated with OA
131
Solidago spp. - actions? - pulm indication? kidney indication? - contraindicated?
Goldenrod aerial parts **Asteraceae family** - antimicrobial and anticatarrhal, anti-inflammatory, diuretic, carminative, expectorant indicated: URTI with catarrh*, influenza, flatulence, cystitis, urethritis, dysuria, anuria contraindicated in high doses and aster allergy
132
Symphytum officinale - used internally and externally for? - what does it contain? how is that harmful?
Comfrey root, rhizome, and leaf - demulcent (ulcers), expectorant, vulnerary used topically for wound healing, astringent (hemorrhages) * allantoin stimulates cell proliferation to support wound healing - internal and external* topical: wounds, dermatitis, osseous fractures, ulcer, bruises, gingivitis, mastitis internal: dry cough, hemoptysis, inflammation of the lungs and GI, UTI, dysentery, GU bleed AEs: HVOD, hepatic failure CIs: cannot use internally d/t **unsaturated** pyrrolizidine alkaloids that are heptotoxic, carcinogenic, and mutagenic **saturated ones are OK (tussilago, inula, echinacea)** **use with caution if sign of infection as it can cause would to close too soon and trap the infection**
133
Tanacetum parthenium - main indication? - contraindicated? - interactions?
Feverfew leaf and flower **Asteraceae family** - antiinflammatory (inhibits PGs, not COX. blocks plt granule secretion, decreases vascular smooth muscle spasm), vasodilator, bitter, antitumor, anti mast cell indicated: prevention and treatment of *migraine headaches (so is petasites but isnt on our list), digestive problems, RA, irregular menstruation topical: antispetic, toothache, insecticide AEs: blood thinning contraindicated: **pregnancy - may stimulate uterine contractions**, aster family interacts: morphine, blood thinners
134
Tanacetum vulgare - components that lead to properties? - indications? - pregnancy?
Tansy flowering herb **low dose herb** **asteraceae family** * thujone - insect repellent *sesquiterpene lactones in leaves are antimicrobial and antihelminthic *polysaccharides are ulcer protective - emmenagogue, bitter, and astringent indicated: worms, parasites, gingivitis, weak digestion, amenorrhea contraindicated: pregnancy, GI irritation
135
Taraxacum officinale - root/leaf differences - dont use with what pharms? which vit does it deplete?
Dandelion root/leaf **asteraceae family** - root is a hepatotonic and cholagogue, bitter, antirheumatic, anti-inflammatory - leaf is a bitter, diuretic, antiviral, choleretic root: poor digestion, cholecystitis leaf: lower UTIs, urolithiasis, edema, topical warts, CHF leaf: contraindicated w use of BBs contraindicated in bitter digestive complaints and asteraceae whole plant is diuretic (avoid with Lithium) interacts: PPIs, Li, hypoglycemics, *reduces vit B absorption*
136
Theobroma cacao - indicated for? - can cause what 3 SEs?
Cocoa seed skins purine alkaloids (theobromine and caffeine), fats (oleic and stearic acid), protein substances, starch, saccharides (glucose and fructose), isoquinolone alkaloids, catechin tannins -methylxantines/thebromine: diuretic, broncholytic, and vasodilatory, muscle relaxant, stimlate cardiac muscle indications: bronchial smooth muscle spasms, cardiovascular health, diarrhea AEs: tannins can cause constipation, insomnia in high doses, amines can trigger a migraine
137
Thuja occidentalis - topical? internal uses? - avoid at high doses due to? - contraindicated?
Thuja leaves genitourinary antiseptic, diuretic topical: warts, leukorrhea, anal fissures, chancre, ulcers internal: pharyngitis, tonsillitis, bronchitis, incontinence, enuresis, GU catarrh AEs (at high doses): N/V/impotence, fatty liver, insomnia, nightmares, hallucinations, convulsions. Thujone is an emmenagogue, abortifacient, and possible carcinogen CI: large doses (thujone), pregnancy (abortifacient(, and lactation
138
Thymus vulgaris | - actions? indications?
Thyme leaf and flowering top - bronchial antispasmodic and expectorant, antibacterial, antifungal, antiviral, protozoan, antioxidant, spasmolytic, carminative indicated: dyspepsia and slow digestion, infected wounds and respiratory and digestive infections, spasmodic cough, eases sore throats contraindications: long term use, pregnancy
139
Tilea europa | - indicated?
Linden flower diaphoretic, antitussive, spasmolytic, nervine, analgesic indicated: cough and bronchitis
140
Tribulus terrestis - effects in men? women? heart? - indicated? - contraindicated? - interacts which what 3 pharm class?
Bindii aerial parts - sex hormone enhancer (estrogenic in females and androgenic in males), negative chronotropic indications: infertility, impotence, decreased libido, fatigue, convalescence, CAD AEs: aggravates GERD, insomnia, menorrhagia contraindicated: GERD, cholestasis, BPH, pregnancy, lactation interacts: could potentiate cardiac glycosides, BBs, and CCBs
141
Trifolium pratense - actions? indications? - contraindications?
Red Clover flower - alterative, expectorant, anti-spasmodic, anti-tumor indicated: childhood eczema, psoriasis, chronic skin conditions (topical). coughs, bronchitis, whooping cough cancerous growths (topical) contraindicated: estrogen sensitive breast cancers (disproven), bleeding disorders interacts: warfarin
142
Tussilago farfara - contains what constituent? what mineral? indicated? - how should it be prepared?
Coltsfoot flower and leaf *pyrrolizidine alkaloids: antibacterial, carcinogenic and hepatotoxic. demulcent, antiinflammatory (zinc content), antitussive, expectorant, antispasmodic indicated: soothing expectorant for as antispasmodic cough, chronic or acute bronchitis, irritating cough, whooping cough, asthma AEs: pyrrolizidine alkaloids - however no danger if they are in a **tea form in low amounts** contraindicated: pregnancy, lactation synergistic w hepatotoxic drugs
143
``` Ulmus rubra (fulva) - take 2 hours away from ? ```
Slippery Elm inner rind demulcent, astringent, anti-inflammatory indicated: irritated and inflamed mucus membranes, externally as a poultice for wounds burns and swollen glands take 2 hours away from iron
144
Urtica dioica - topically used for? externally? - contraindicated? - interacts with which supplement?
Stinging Nettle flowering plant and roots - leaf is astringent, diuretic, rubefacient, counter-irritant - lignans in the root bing to SHBG of prostate tissue, inhibiting prostate cell metabolism and growth (BPH sx relief), *think 5aR inhibitor* topical flowering plant: rubefacient for rheumatic dz internal flowering plant: UTIs, kidney and bladder stones internal root: prostate, irritable bladder - reduces prostate sxs by reducing residual urine and increasing flow *it does not eliminate the enlargement* AEs: stinging from the fresh leaf contraindicated: pregnancy (diuretic effects), when there is fluid retention d/t reduced heart or kidney function interacts: tannins *iron*
145
Usnea barbata - anti? not anti? - what bugs does it get?
Old Man's Beard antimicrobial and antifungal (not so much antiviral), bitter inhibits gram + bacteria, M tuberculum, pneumococcus, strep hemolyticus, corynebacterium diphtheriae can be hepatotoxic when using isolated usneic acid
146
Vaccinium myrtillus - used for? - interacts?
Bilberry, Blue Berry leaf and fruit - contains potent antioxidants, used for microvascular protection, venotonic, anti-diarrheal, nutrient, astringent, hypoglycemic leaf: acute or chronic dysentery, cystitis, DM, (external for burns or skin disease) fruit: diarrhea, myopia, retinopathies, inflammation, varicose veins AEs: diarrhea, long term use of leaf can damage liver and kidneys d/y hydroquinones contraindicated: pregnancy, lactation interacts: insulin, hypoglycemics, tannins
147
Valeriana officinalis - which NT does it effect? - contraindicated in? - interacts with other things that affect? lifestyle? - could decrease the absorption of ? due to ? content
Valerian root - sedative, anodyne, spasmolytic, decreases degradation of GABA indicated: insomnia, anxiety, smooth muscle spasms, epilepsy AEs: drowsiness, headache, vertigo, restlessness, insomnia GERD, CNS paralysis contraindications: liver disease interactions: dont mix with other hepatotoxic agents - alcohol, opioids, barbs, benzos. *tannin content could decrease iron absorption
148
Veratrum album/viride - actions? - what drug is the antidote in overdose?
american hellebore dried rhizome and root **low dose herb** -circulatory depressant, antispasmodic, hypotensive album: protoveratrine A and B are sensory nerve irritants and inhibit activation of Na channels - indicated: internal hypertension and topical insecticide viride: alkaloids inhibit activation of Na channels in heart cell regulators to reduce BP and slow HR - indicated: rapid full pulse, HTN, fever, inflammation, flushed skin, blood shot eyes AEs: lacrimation, salivation, vomiting, burning sensation in mouth and throat, inability to swallow, vertigo, paralysis, convulsions, death **give atropine and send to ED** **do not ever prescribe this. extremely toxic** CI in pregnancy and lactation
149
Verbascum thapsus - used for? - keynote cough? - contraindicated?
Mullein leaf and flower demulcent, relaxing expectorant, astringent, antitussive. GU sedative, anodyne, diuretic indicated: internally to reduce *hard cough with soreness* coughing and respiratory irritation (less commonly chronic cystitis and urinary incontinence), externally for otitis media/externa and rheumatic joints **internal use is controversial bc it contains pyrrolizidine alkaloids > liver damage**
150
Verbena officinalis - indications? contraindications? - pregnancy? lactation?
Vervain aerial parts - diaphoretic, expectorant, galactogogue, emmenagogue, antiperiodic (the prevention of commonly recurring sxs) * iridoid glycosides can cause paralysis and stimulates the uterus at high doses. verbenaline has antitussive and lactation-promoting properties indicated: fever, sore throat, gargle, itchy skin, burns, arthritis, rheumatism, dislocations, contusions dont use in pregnancy
151
Viburnum opulus and prunifolium | - actions and indications
Cramp bark and Black Haw bark and root -spasmolytic, astringent, emmenagogue, nervine, sedative, hypotensive indicated: dysmenorrhea, endometriosis, PMS, threatened miscarriage, premature labor, smooth muscle spasms, acute urolithiasis, myalgia, HTN, arthritis raw fruit will cause GI discomfort
152
Vinca major/minor - what does it contain? - what drug is derived from it? to treat what?
Greater and lesser periwinkle dried leaves - hypotensive: vincamine alkaloids - circulatory stimulant/increased blood flow to the brain: vinpocetine pharmaceutical for alzheimers is derived from vincamine indiacted: circulatory disorders, cerebral circulatory impairment, memory loss, hypertension, concussion management (get a CT first to rule out brain bleed) AEs: GI complaints, flushing contraindicated: pregnancy, severe cerebral hemorrhage
153
Viscum album Viscum flavescens (Phoradendron serotinum) - used in? - use away from what supplement?
European/American mistletoe twigs **low dose herb** - hypotensive, cytotoxic, immunostimulating: lectins: stimulated mononuclear phagocytic system and macrophage derived cytokines - antineoplastic: stimulation of enzymes that repair damaged DNA - anti-inflammatory, cerebral circulatory stimulant indicated: subQ injection: tumor inhibition internal: HTN, weak irregular heart with hypertrophy, SOB, valvular insufficiency, nervous tachycardia, epilepsy, neuralgic or rheumatic pains AEs: local inflammation around site, high fever, chills, headaches, death contraindicated: chronic and progressive infections (TB, AIDS), CNS or spinal tumors, pregnancy, fever, allergy interacts: tannins might complex with iron
154
Vitex agnus-castus - effects on hormones? - indications? - contraindicated? - interacts with pharms that affect which NT?
Chaste Tree berry - normalizes female sex hormones and pituitary gland function, uterine tonic (supports the corpus luteum by increasing progesterone and decreasing estrogen), galactagogue indications: teen acne, fibroids cysts, trying to conceive, post OCP use, irregular menstruation, short cycles, dysmenorrhea, PMS, menopause AEs: rashes contraindicated: stop taking as soon as you become pregnant, lactation interacts: DA antagonists and DA receptor blocking agents
155
Withania somnifera - used for? - interactions with drugs?
Ashwagandha root -Adaptogen, immune modulating, hypotensive, sedative, enhances cognition indicated: stress, inflammation, insomnia, nervous exhaustion, asthma, bronchitis, infection, anxiety, low libido, opiate withdrawal contraindicated: pregnancy interacts: barbiturates, epileptics, immune suppression therapy
156
Zingiber officinale | - dont take more than how many grams in preg?
Ginger root carminative, antispasmodic, warming stimulant, anti-emetic, rubefacient, diaphoretic, emmenagogue, anti-inflammatory indicated for: nausea, flatulence, abd discomfort, and diarrhea, loss of appetite, motion sickness, RA (inhibits COX and LOX) AEs: Gi complaints contraindicated: no more than 2 g in pregnancy, dont take with gallstones, not in pts at risk of hemorrhage interacts: anticoags
157
ZZ. Herbs that should not be used in children
Larrea, coleus, chelidonium, rhamnus, atropa, uva ursi, salix alba
158
ZZ. Herbs with cardiac glycosides
coleus, convallaria, digitalis, leonurus
159
ZZ. herbs/drugs with hypokalemic effects which class of herbs do we want to avoid with hypokalemic substances?
diuretics (furosemide, HCTZ) corticosteroids (hydrocortisone, prednisone, dexamethasone) cardiac glycosides (digoxin, convallaria, digitalis, leonurus) anti-arrhythmics (atenolol, propranolol, amiodarone) pseudoephedrine Glycyrrhiza AVOID: diuretics and laxatives (as they can add to hypokalemia)
160
ZZ. Low dose herbs
``` Aconitum, Aspidosperma, Atropa Baptisia, Bryonia Convallaria Datura, Digitalis Ephedra Gelsemium sempervirens Hyoscyamus niger Iris versicolor Lobelia, Lycopus, Larrea Yohimbe, Phytolacca, Piper methysticum, piscidia, Podophyllum, Pulsatilla Rauwolfia Sanguinaria, Selenicereus Tanacetum, Thuja Veratrums, Viscums ```
161
ZZ. Name the 14 plants in the asteraceae family | People with allergies to the following should avoid Asters: pollen, ragweed, chrysanthemums, marigolds, daisies, etc
``` Arnica, Artemesia Calendula, Cynara Echinacea, Eupatoriums Grindelia Inula Matricaria Silybum, Solidago Tanacetum, Taraxacum, Tussilago ```
162
ZZ. pharmaceuticals (7) that have anticholinergic effects, and which herbs we avoid with them?
atropine, bupropion, dextromethorphan, dicyclomine, diphenhydramine, tiotropium bromide, tolterodine belladonna, stramonium, hyoscyamus
163
ZZ. we avoid these disease processes with bitter digestive stimulants
GERD, active peptic ulcers, gastritis, biliary obstruction, acute cholelithiasis, diarrhea
164
ZZ. What needs to be avoided with Lithium due to increased risk of ?
diuretics: specifically arctium, galium, taraxacum whole plant
165
ZZ. Which five herbs would you pick for acne: Achillea, Arctium, Berberis aquifolium, Rumex, Galium, Plantago, Symphytum, Solidago, taraxacum
arctium, berberis, rumex: inflammatory and hormonal skin conditions - acne galium: alterative and lymphatic - acne and chronic skin diseases taraxacum (whole plant): hepatoprotective and diuretic achillea - bitter digestive stimulant, vulnerary, styptic plantago - demulcent and vulnerary for dermatitis, wounds and ulcerations symphytum - demulcent, expectorant, vulnerary used topically for wound healing solidago spp - antimicrobial and anticatarrhal used in URTI
166
ZZ. Which four would you use for reduction of pain and inflammation associated with OA? Boswellia serrata, Fucus vesiculosis, Curcuma longa, Esch californica, Corydalis spp. Harpagophytum procumbens, Smilax spp
Harpagophytum, Smilax, Curcuma, and Boswellia fucus: RA and hypothyroidism Corydalis: analgesic, hypnotic, and sedative used in dysmenorrhea Esch: nerve pain, anxiety, insomnia (not joint pain)
167
ZZ. Which herbs contain pyrrolizidine alkaloids and why would they be unsafe?
hepatotoxic and carcinogenic in large doses - petasides hybridus (not on list) - verbascum - symphytum - tussilago
168
ZZ. Which plants are not safe for internal use?
Verbascum, Sanguinaria, Podophyllum, Pulsatilla, Melaleuca, Cineraria maritima, Bryonia *there mighttttt be more
169
ZZ. Which six might you use for prostate cancer? Larrea tridentata, Sanguinaria, Ginkgo biloba, Ganoderma lucidum, Serenoa repens, Hydrangea arborescens, Juniperus communis, Curcuma longa, Gallium aparine, Camellia sinensis
Ganoderma, Curcuma, Larrea, Ginkgo, Camellia - antineoplastic serenoa: inhibits T activity arctostaphylos uva-ursi, hydrangea, juniperus: antimicrobial and used in UTIs gallium: alterative for chronic skin disease and lower urinary tract infections - not prostate CA sanguinaria: rarely used internally d/t escharotic action
170
ZZ. Which three are indicated for uncomplicated cystitis? althea, alium, solidago, zea mays, eupatorium, matricaria, arctostaphylos uva-ursi
zea mays, althea, uva ursi (however they are not indicated in pyelonephritis - use ABX) allium is antimicrobial, but not for UT eupatorium is a diaphoretic and immune and digestive stimulant with an affinity for the resp and GI systems
171
ZZ. Which three would be useful and safe in HIV infection? Panax ginseng, Glycyrrhiza glabra, Larrea, Baptisia, Echinacea, Hypericum, Usnea, Hydrastis, Solidago
Panax ginseng, Glycyrrhiza and Echinacea - helpful in HIV infection Hypericum is also helpful in HIV infection, but is avoided in pts on ART Larrea: cancer and infection, not HIV Solidago: URTI with significant cattarh Usnea: antmicrobial Baptisia: URI with cattarh Hydrastis: antimicrobial and immune modulating
172
ZZ. Which three would you pick for IBS? mentha piperita, melissa officinalis, urtica dioica, zingiber officinale
melissa, mentha, zingiber
173
ZZ. which herbs effect breast milk?
lessens: salvia increases: glycyrrhiza, verbena
174
ZZ. which herbs would you avoid with sympathomimetics? what are the sympathomimetics?
ephedra, yohimbe, rauwolfia S: albuterol, epinephrine, phenylephrine, pseudoephedrine, salbutamol
175
ZZ. go through all of the coughs and which herb is indicated? wet, dry, spasmodic?
wet: aspidosperma, inula*, lobelia*, sanguinaria dry: grindelia, inula*, symphytum spasmodic: asclepius, ceanothus, datura, hyoscyamus, inula*, larrea, lobelia*, prunus, thymus, trifolium, tussilago
176
ZZ. Herbs that interact with CYP: | inhibitors and inducers
garlic (allium sativum), ginkgo, ginseng, goldenseal (hydrastis), grapefruit juice milk thistle, SJW, echineacea, piper methysticum, vaccinium, mentha piperita